Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based AssaysArticle Published on 2021-12-312022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] activities activity acute respiratory syndrome ADME African Analysis B.1.1.7 B.1.351 B.1.617.2 bind Candidates Compound concern coronavirus COVID-19 Cytopathic effect delta variant demonstrated distribution facilitate fusion fusion inhibitor half-maximal inhibitory concentration in vivo India inhibited inhibitor inhibitors inhibitory lowest Major MERS-CoV metabolism Middle East Middle East respiratory syndrome (MERS) oral bioavailability pan-coronavirus potent Potential prefusion prevented respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome (SARS) small molecule South SPR surface plasmon resonance trimer variant variants of concern VOCs [DOI] 10.3390/v14010069 PMC 바로가기 [Article Type] Article
The First Death in Japan Attributed to COVID-19: A Brief ReportInternal Medicine Published on 2021-12-262022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory distress syndrome [ards] acute respiratory syndrome Admission Analysis Chest computerized tomography Contact coronavirus coronavirus disease COVID-19 COVID-19 pneumonia death diagnostic died fatigue Fever ground-glass opacity had no hospital Hypoxemia individual infection control Japan Lungs Measures negative pressure chamber Nosocomial infection Patient Pneumonia polymerase chain positive Prevent prevented report respond RT-PCR SARS-CoV-2 Treatment Wuhan [DOI] 10.7759/cureus.20721 PMC 바로가기 [Article Type] Internal Medicine
COVID-19–Related Rumor Content, Transmission, and Clarification Strategies in China: Descriptive StudyOriginal Paper Published on 2021-12-232022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] 95% CI article Characteristics China circulating circulation Clarification complicate content COVID-19 COVID-19 epidemic COVID-19 pandemic COVID-19 patient decrease diagnosed early stage Effectiveness evaluated faster Government Guangxi Health highlight information Local media mitigate MONITOR Novel coronavirus objective occurred permeation prevented proportion public health public health emergency response Result retrieved rumor severity significantly social media Spread Strategy Symptom urgency website Zhejiang [DOI] 10.2196/27339 PMC 바로가기 [Article Type] Original Paper
COVID-19 Testing and Case Rates and Social Contact Among Residential College Students in Connecticut During the 2020-2021 Academic Year2020-2021 학년도 동안 코네티컷의 거주 대학생 사이의 COVID-19 테스트 및 사례 비율 및 사회적 접촉Research Published on 2021-12-232022-09-10 Journal: JAMA Network Open [Category] SARS, 변종, 진단, 치료기술, [키워드] 95% CI Antigen approach approaches association blunt Campus Chain Reaction cohort study college Connecticut Contact COVID-19 COVID-19 cases COVID-19 testing decrease effective exposure finding Frequency group Guidance higher education Importance increase in Infection measure mitigate objective outcome participant performed Point polymerase chain polymerase chain reaction prevented Rate reduce Relevance reopening Result retrospective cohort study risk SARS-CoV-2 transmission SARS-CoV-2 variants setting social contact Social distancing measure social distancing measures Spread student Test tested Testing Transmission universities used data vaccination variety Year [DOI] 10.1001/jamanetworkopen.2021.40602 PMC 바로가기 [Article Type] Research
Erythrocytes increase endogenous sphingosine 1-phosphate levels as an adaptive response to SARS-CoV-2 infectionArticle Published on 2021-12-222022-10-06 Journal: Clinical Science (London, England : 1979) [Category] SARS, 진단, [키워드] adaptive adaptive mechanism carriers coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critically ill patient Culture down-regulation Endothelial cell endothelial cell barrier erythrocyte erythrocytes experiment expression HDL healthy control high-density High-density lipoprotein hypoxia Immunity Infection lymphopenia metabolite observation plasma prevented producing RBC RBCs red blood cell reduced SARS-CoV-2 SARS-COV-2 infection serum albumin Signaling significantly increased sphingosine supported tissue Total vasculature [DOI] 10.1042/CS20210666 PMC 바로가기 [Article Type] Article
Lessons learnt from the first large outbreak of COVID-19 in health-care settings in Tasmania, AustraliaCovid-19 Published on 2021-12-222022-10-28 Journal: Western Pacific Surveillance and Response Journal [Category] COVID-19, MERS, SARS, [키워드] Action affected amplified changed close contact Context contributed coronavirus disease COVID-19 COVID-19 pandemic Factor HCW HCWs health-care hospital Hospital admission hospitals implementation index cases infection control initial Isolation lesson management Nurses outbreak Patient physical distancing Positive test prevented problem public health authority Public health intervention reduce required returned SARS-CoV-2 nucleic acid symptomatic Transmission Travel [DOI] 10.5365/wpsar.2021.12.4.884 PMC 바로가기 [Article Type] Covid-19
Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beatingBiochemistry Published on 2021-12-202022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 48 hours abrogate Affect arrhythmia cardiomyocyte cause Cell cell death chaperone condition consequence COVID COVID-19 patients described detrimental effect disrupt downregulating dysfunction expressed expression Frequency infect inhibition investigated IPSC myocarditis number of infected prevented pro-inflammatory cytokine Protective effects receptor reduced reducing reported SARS-CoV-2 SARS-COV-2 infection sigma-1 receptor survival therapeutic potential therapeutic target triggered viral particle [DOI] 10.7717/peerj.12595 PMC 바로가기 [Article Type] Biochemistry
Resource and infrastructure challenges on the RESIST-2 Trial: an implementation study of drug resistance genotype-based algorithmic ART switches in HIV-2-infected adults in Senegal저항 2 시험의 자원 및 인프라 과제 : 세네갈의 HIV-2에 감염된 성인의 약물 저항성 유전자형 기반 알고리즘 아트 스위치의 구현 연구Clinical Trial Published on 2021-12-182022-09-01 Journal: Trials [Category] SARS, 임상, 진단, [키워드] AIDS Algorithm antiretroviral drugs Antiretroviral therapy ART Blood can be used conducted Controlled trial counseling COVID-19 COVID-19 pandemic defined demonstrated dolutegravir drug resistance drug resistance testing enrolled Evidence evidence of Follow-up funding genotypes genotypic help HIV treatment HIV-2 implementation Implementation study inhibitor lack mutations National no evidence of nucleoside outcome participant Participants Patient per-protocol point-of-care prevented problem problems protease Protease inhibitor receiving regimen Result reverse transcriptase RLS Seattle single-arm trial suppressed switching transcriptase Treatment Trial Trial registration Viral Viral load Viral suppression VL testing was performed were assessed [DOI] 10.1186/s13063-021-05902-5 PMC 바로가기 [Article Type] Clinical Trial
Risk-benefit analysis of the AstraZeneca COVID-19 vaccine in Australia using a Bayesian network modelling framework베이지안 네트워크 모델링 프레임워크를 사용한 호주 AstraZeneca COVID-19 백신의 위험-편익 분석Article Published on 2021-12-172022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] Adverse adverse events age age and sex Analysis AstraZeneca Atypical AZ vaccine Bayesian Bayesian network Bayesian networks benefit blood clot Blood clots Case fatality rate CFR COVID-19 COVID-19 vaccine death doses Effectiveness estimate Evidence example Fatality rate first dose Government group groups incidence International knowledge Local Model Other outcomes outcome portal Portal vein portal vein thrombosis portal vein thrombosis) prevented Probability reported Risk-benefit analysis SARS-CoV-2 SARS-CoV-2 variant severe disease Sex significantly Sinus thrombosis thrombocytopenia thrombosis Thrombosis/thrombocytopenia syndrome Transmission vaccination Vaccine vaccine doses Vaccines Variation venous venous sinus was used [DOI] 10.1016/j.vaccine.2021.10.079 PMC 바로가기 [Article Type] Article
Reduced transmission of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) in patients with haematological malignancies hospitalized in an Italian hospital during the COVID-19 pandemicBrief Report Published on 2021-12-172022-10-29 Journal: JAC-Antimicrobial Resistance [Category] COVID-19, [키워드] acquisition Administered Aggressive analysed applied bloodstream infection BSI characterized clinical complication Consumption COVID-19 COVID-19 pandemic Effect effort eight evaluated hospital Hospitalized hospitalized patient hospitalized patients Italian Italy Klebsiella Klebsiella pneumoniae lockdown malignancies malignancy measure nosocomial objective outcome Patient patients patients hospitalized patients with haematological Pneumonia pneumoniae positive Prevent prevented reduced Result SARS-COV-2 infection SARS-CoV-2 transmission Seven significantly Spread Transmission two group [DOI] 10.1093/jacamr/dlab167 PMC 바로가기 [Article Type] Brief Report