An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse ModelADAM17 중화 항체는 COVID-19 마우스 모델에서 바이러스 부담을 증가시키면서 염증과 사망률을 감소시킵니다Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 ADAM17 ADAM19 adverse outcome Alter angiotensin anti-viral role antibody appear blockade blocked burden Cell cell entry receptor cellular activation cleave COVID-19 COVID-19 pathogenesis COVID-19 patients Critical ectodomain Increasing Inflammation Inflammatory inflammatory cascade K18-hACE2 less lung Lung pathology lung; metalloproteinase mice Model monoclonal antibody mouse mouse model pathway Proinflammatory cytokine promote protease Proteins SARS-CoV SARS-CoV-2 SARS-CoV-2 viruses significantly increased significantly lower therapeutic TNF-α Transgenic mouse transmembrane viral burden virus while [DOI] 10.3389/fimmu.2022.918881 PMC 바로가기 [Article Type] Article
Mechanism of COVID-19-Related Proteins in Spinal Tuberculosis: Immune Dysregulation척수결핵에서 COVID-19 관련 단백질의 메커니즘: 면역 조절 장애Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Accuracy Analysis AUC B cell B cells bioinformatics C-index calculated calibration curve Cell clinical Clinical data collected coronavirus disease COVID-19 degree Diagnosis differentially expressed dysregulation enrichment analysis expression external validation Factor Gene ontology immune Immune cell immune cells immune dysregulation immune genes immune mechanism indicated Intersection intervertebral intervertebral disc involved KEGG KEGG pathway low expression Lymphocytes MCC mechanism mechanisms negative correlation nine nomogram PPI predicted Predictive Protein protein-protein interaction Proteins risk ROC Curve RPL19 significantly lower spinal spinal tuberculosis. suppress tissue tissues training set Tuberculosis was used were used [DOI] 10.3389/fimmu.2022.882651 PMC 바로가기 [Article Type] Article
Early Th2 inflammation in the upper respiratory mucosa as a predictor of severe COVID-19 and modulation by early treatment with inhaled corticosteroids: a mechanistic analysis중증 COVID-19의 예측인자로서 상부 호흡기 점막의 초기 Th2 염증 및 흡입 코르티코스테로이드 조기 치료에 의한 조절: 기계론적 분석Clinical Trial Published on 2022-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, 치료제, [키워드] 1:1 adaptive airway Analysis Anti-viral antipyretics assigned AstraZeneca Biomarker Blood blood sample Blood samples Budesonide CCL17 chemokine clinical benefit clinical symptom clinical trial clinically Cohort collected Concentration Corticosteroid Course COVID-19 COVID-19 disease COVID-19 disease course Data collection decrease deteriorate dose early treatment Efficacy elevated enzyme eosinophil epithelial epithelial lining Evolution experimental analysis healthy controls healthy individuals IL-33 immunoassay individual Inflammation Inflammatory Inflammatory mediators Inflammatory response Inhaled inhaled budesonide inhaled corticosteroid initial interferon interferon response interleukin Intervention investigated Ligand marker mechanism Meso Scale Discovery modulated modulation mucosa mucosal nasal Nasal sample nasal samples Necrosis negative control nose Observational data open label outcomes over Oxford parallel group participant Patient patients with SARS-CoV-2 Phase 2 Primary outcome Proteins randomisation randomised Randomly receive recruited reducing Registered respiratory tract SARS-COV-2 infection severe COVID-19 severe COVID-19 disease shown systemic inflammation T-cell Response Th2 the SARS-CoV-2 Treatment Trial tumour necrosis factor tumour necrosis factor-α twice a day University of Oxford upper respiratory usual care usual care group was collected were assessed were used Whole blood with COVID-19 [DOI] 10.1016/S2213-2600(22)00002-9 PMC 바로가기 [Article Type] Clinical Trial
A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virusSARS-CoV-2 변이체에 대해 설계된 보존 소단위 백신은 바이러스를 중화하는 증거를 보여주었습니다Article Published on 2022-06-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition affinity analyzed antibody approach B-cell response conserved coronavirus coronavirus disease country Coverage COVID-19 Cytopathic effect docking domain Efficiency elicit envelope envelope protein epitope Epitope-based vaccine Epitopes Evidence FIVE genomes glycoprotein highest IgG immunogenic immunoinformatics IMPROVE induce linker lung tissue membrane membrane glycoprotein MHC MHC class MHC class I MHC class II mice molecular molecular docking Multi-epitope vaccine Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody novel Novel coronavirus omicron outbreak pandemic peptide peptides Proteins recognize reported required S1 and S2 S2 domain SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequences spike Spike surface glycoprotein, Immunogenic, Neutralizing antibody. Spread step subunit Subunit vaccine Surface glycoprotein surface protein surface proteins T-cell T-cell epitope T-cell epitopes the vaccine Vaccine vaccine construct variant variants variants of SARS-CoV-2 Vero Cell viral surface virus virus replication wild type wild-type virus [DOI] 10.1007/s00253-022-11988-x PMC 바로가기 [Article Type] Article
Addition of arginine hydrochloride and proline to the culture medium enhances recombinant protein expression in Brevibacillus choshinensis: The case of RBD of SARS-CoV-2 spike protein and its antibodyarginine hydrochloride와 proline을 배지에 첨가하면 Brevibacillus choshinensis에서 재조합 단백질 발현이 향상됩니다: SARS-CoV-2 스파이크 단백질의 RBD 및 그 항체의 경우Article Published on 2022-06-012022-09-11 Journal: Protein expression and purification [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 96-well plates addition Analysis anti-SARS-CoV-2 antibody antibody arginine arginine hydrochloride B.1.1.529 Bacterial bacterial cell bacterial cells bacterial strains Brevibacillus Cell condition contribute CoV-2 Culture culture medium demonstrated ENhance Escherichia coli eukaryotic eukaryotic cell exhibited expressed expression Fab functional functional expression gram-positive bacterium High-throughput expression and purification indicated medium Omicron variant physicochemical produced producing proline Protein protein expression Proteins purification RBD RBD of SARS-CoV-2 RBD. Receptor binding domain recombinant proteins reported SARS-CoV-2 spike protein secrete Spike protein strain the SARS-CoV-2 wild-type [DOI] 10.1016/j.pep.2022.106075 PMC 바로가기 [Article Type] Article
Analysis of a SARS-CoV-2 convalescent cohort identified a common strategy for escape of vaccine-induced anti-RBD antibodies by Beta and Omicron variantsSARS-CoV-2 회복기 코호트 분석에서 베타 및 오미크론 변이체에 의한 백신 유도 항-RBD 항체의 탈출을 위한 공통 전략 확인Article Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S allergy Alpha Analysis anti-RBD Anti-RBD antibody anti-spike antibody antibody Antibody binding Antibody Response antibody response against Antibody titer Antibody titers assays Beta blood draw blood draws blood sample BNT162b2 Boston Cohort collected convalescent COV2.S COVID COVID-19 cross-reactive antibodies cross-reactive antibody Delta Donor evade evaluate expected fraction hybrid Hybrid immunity Immune escape immune evasion Immunity increase increase in Infectious disease Infectious diseases initial limitation Massachusett mRNA mRNA-1273 mutant Mutation neutralization Neutralization escape mutations omicron Omicron variant plasma polyclonal polyclonal antibody Post-infection proportion proportions Proteins RBD RBDs Re-infection readiness Receptor binding domain residue residues SARS-CoV-2 SARS-CoV-2 variants spike Spike protein Structural analysis the spike protein vaccination Vaccine induced antibody titers. variant variants variants of concern were excluded were used [DOI] 10.1016/j.ebiom.2022.104025 PMC 바로가기 [Article Type] Article
[Nirmatrelvir plus ritonavir (Paxlovid) a potent SARS-CoV-2 3CLpro protease inhibitor combination][니르마트렐비르와 리토나비르(팍슬로비드)의 강력한 SARS-CoV-2 3CLpro 프로테아제 억제제 조합]Review Published on 2022-06-012022-09-11 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL 3CLpro Administered adverse effects Antiviral antiviral drug antiviral drugs antiviral efficacy approved average conserved coronavirus Coronaviruses death duration of treatment effective Effectiveness EMA English FDA Final Hospitalization IMPROVE indican inhibitory activity media metabolism Modification Nirmatrelvir NSP11 Pandemia pandemic Patient Paxlovid PF-07321332 polyproteins pp1a pp1ab processing protease Protease inhibitor Proteases Proteins reducing risk Ritonavir SARS-CoV-1 SARS-CoV-2 sequence shown Spanish therapeutic target Treatment Viral variants [DOI] 10.37201/req/002.2022 PMC 바로가기 [Article Type] Review
Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small MoleculesSARS-CoV-2에 대한 새로 등장한 항바이러스 전략: 바이러스 단백질 구조 기능 해독에서 백신, 항체 및 소분자 개발까지Review Published on 2022-05-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antibody treatment Antiviral caused chemical compounds clustered regularly interspaced short palindromic repeats compounds contribute coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection CRISPR development disease pathogenesis DNA dual exploration focus function functional Health Health crisis host cells inactive Infection inhibitors life cycle molecule monoclonal antibodies monoclonal antibody mRNA nonstructural proteins palindromic repeat Particles peptide-based Protein protein-based vaccine Protein-based vaccines Proteins provide research findings respiratory RNA vaccines SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus single-stranded Strategy structural proteins structure-function systematic review target targeted therapy targets the SARS-CoV-2 genome therapeutic option Therapeutic strategies therapy Treatment Vaccine Vaccine development Vaccines Viral viral life cycle Viral protein Viral proteins viral replication virus [DOI] 10.3390/ijms23116083 PMC 바로가기 [Article Type] Review
Reduced Antibodies and Innate Cytokine Changes in SARS-CoV-2 BNT162b2 mRNA Vaccinated Transplant Patients With Hematological Malignancies혈액암이 있는 SARS-CoV-2 BNT162b2 mRNA 백신 접종 이식 환자의 감소된 항체 및 선천적 사이토카인 변화Article Published on 2022-05-252022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] adaptive antibodies antibody approach Beta BNT162b2 mRNA vaccination Bone marrow booster vaccination CAR-T cell change Cohort cohorts correlated COVID-19 vaccination CXCL10 cytokine cytokine response Delta described develop Effectiveness Efficacy elicited healthy hematological hematological cancer Hematological malignancies Hematological malignancy heterogeneous high risk humoral Humoral response IFN-gamma IFN-γ IL-10 IL-15 IL-7 IL-8 individual Innate innate response IP-10/CXCL10 magnitude MIP-1α mRNA naïve neutralized offer omicron Patient patient cohort Predictive priming vaccination prognostic protection Proteins recipients reduced response SARS-CoV-2 SARS-CoV-2 BNT162b2 SARS-CoV-2 bnt162b2 mRNA vaccine SARS-COV-2 infection severe disease signature response significantly lower spike systemic cytokine response the patient the Spike Transplant transplantation vaccination Vaccine WA1 wildtype Wuhan strain [DOI] 10.3389/fimmu.2022.899972 PMC 바로가기 [Article Type] Article
Markers of endothelial cell activation are associated with the severity of pulmonary disease in COVID-19내피 세포 활성화의 마커는 COVID-19에서 폐 질환의 중증도와 관련이 있습니다Article Published on 2022-05-192022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] activate activated Activation acute respiratory distress acute respiratory distress syndrome Antigen association Biomarker Biomarkers biomarkers of inflammation characterized chemokines coronavirus coronavirus disease Coronavirus disease-19 Coronavirus infection correlated COVID-19 cytokine Cytokines D-dimer death endothelial Endothelial cell endothelial cells endothelial injury Factor Hypothesis individual Inflammatory response inflammatory state low-flow oxygen Lung disease mechanical ventilation nasal nasal cannula obstruction oxygen Oxygen requirement Oxygenation participant patients with COVID-19 plasma Plasma levels pro-inflammatory cytokine pro-thrombotic Proinflammatory cytokine proinflammatory cytokines Protein Proteins pulmonary disease released respiratory distress Respiratory distress syndrome selectin severe coronavirus disease severe COVID-19 severity single center Support syndrome tested thrombosis vascular disease vascular inflammation vWF with COVID-19 worsening [DOI] 10.1371/journal.pone.0268296 PMC 바로가기 [Article Type] Article