New framework for recombination and adaptive evolution analysis with application to the novel coronavirus SARS-CoV-2Article Published on 2021-04-222023-07-01 Journal: Briefings in Bioinformatics [Category] SARS, [키워드] adaptation Evolution mutation network Recombination SARS-CoV-2 [DOI] 10.1093/bib/bbab107 PMC 바로가기
On the origin and evolution of SARS-CoV-2Review Article Published on 2021-04-162022-10-31 Journal: Experimental & Molecular Medicine [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Atlanta contributed coronavirus coronavirus disease COVID-19 Critical disease Effect effective effort Epidemics events Evidence Evolution Evolution of SARS-CoV-2 Evolutionary biology exhibit facilitated functional Genetic Genome global pandemic growth help Host host cells hosts human cell human population humans infecting Infectious diseases mammalian cells MERS molecular natural selection New Other outbreak Outbreaks pandemic Pandemics Phylogenetic Prevent Protein random Recombination recombination event Region regions responsible resulting S protein SARS-CoV-2 Spread technology the SARS-CoV-2 the SARS-CoV-2 genome the spike protein trajectory USA Variability variants of SARS-CoV-2 viral entry virus zoonotic origin [DOI] 10.1038/s12276-021-00604-z PMC 바로가기 [Article Type] Review Article
Characterizing Transcriptional Regulatory Sequences in Coronaviruses and Their Role in RecombinationArticle Published on 2021-04-042023-07-01 Journal: Molecular Biology and Evolution [Category] SARS, [키워드] Key words: coronavirus Recombination transcriptional regulatory sequences (TRS) [DOI] 10.1093/molbev/msaa281 PMC 바로가기
Limited Genetic Diversity Detected in Middle East Respiratory Syndrome-Related Coronavirus Variants Circulating in Dromedary Camels in JordanCommunication Published on 2021-03-312022-10-28 Journal: Viruses [Category] Coronavirus, Fulltext, [키워드] amplify Arabian Peninsula Camel circulating circulation coronavirus Coronaviruses Diversity Dromedary Endemic genetic diversity Genome sequence data greater Human Jordan Kingdom lack Limited Lineage MERS MERS-CoV MERS-CoV genome Middle East nasal swab nosocomial outbreak pathogen Phylogenomics population genomics Recombination reported respiratory resulting Saudi Arabia sensitivity sequence South Korea subsequent analysis TCID Transmission United Arab Emirate variant viral genomics zoonoses zoonotic [DOI] 10.3390/v13040592 PMC 바로가기 [Article Type] Communication
Recombination Events Shape the Genomic Evolution of Infectious Bronchitis Virus in EuropeArticle Published on 2021-03-242022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] affecting Analysis bronchitis coding coding regions collected Europe European Evidence Genome Genome sequence data Genome sequences genomic Genomic epidemiology genomic evolution Genotype highlighting IBV Infectious bronchitis Infectious Bronchitis Virus involved isolate mechanism morbidity and mortality non-structural proteins Nsp12 NSP2 Nsp3 occurred pathogen Phylogenetic Randomly Recombination recombination event Region selected sequenced Sequencing Seven shape strain Strains Vaccine vaccine strain viral disease Whole-genome sequence [DOI] 10.3390/v13040535 PMC 바로가기 [Article Type] Article
Indels in SARS-CoV-2 occur at template-switching hotspotsResearch Published on 2021-03-202022-10-28 Journal: BioData Mining [Category] COVID-19, [키워드] Analysis breakpoint consensus sequence consensus sequences consequence COVID-19 pandemic de novo Deletion Evidence evolutionary dynamics Genome Genomics GISAID GISAID database heterogeneity homogeneity homologous Host hotspot IMPROVE INDEL indels independent insertion loci mechanism occur other coronaviruses predicted raw reads RdRP Recombination recombination event Region Regulatory replicate RNA RNA secondary structure RNA virus RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution secondary structure sequence Single nucleotide polymorphism Structural variation Structure supplementary material the SARS-CoV-2 Transcription Transcriptome TRS [DOI] 10.1186/s13040-021-00251-0 PMC 바로가기 [Article Type] Research
Genomic Feature Analysis of Betacoronavirus Provides Insights Into SARS and COVID-19 PandemicsMicrobiology Published on 2021-03-172022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute respiratory syndrome ancestor Betacoronavirus cause contribute contributing to Coronavirus-2 CoV COVID-19 Deletion Evolution Factor FCS feature furin cleavage site generate genomes genomic Hairpin Host insertion insight MERS-CoV molecular mechanism new strain ORF8 Pandemics RaTG13 Receptor binding Recombination resulting risk RmYN02 SARS-CoV SARS-CoV-2 SARS1 SARS2 strain Strains subgroups Transcription Transmission virulence [DOI] 10.3389/fmicb.2021.614494 PMC 바로가기 [Article Type] Microbiology
Immunity, virus evolution, and effectiveness of SARS-CoV-2 vaccinesReview Published on 2021-03-152022-10-28 Journal: Brazilian Journal of Medical and Biological Resear [Category] COVID-19, MERS, SARS, [키워드] accessory protein Analysis antiviral effects cellular chemokine clinical symptom complexes coronavirus coronavirus strain COVID-19 COVID-19 patient Cytokines storm DNA repair domains driven by Effectiveness Evolution facilitate Factor Frame function functional Genome Genome sequences global pandemic help Host host cell host cells Immunity immunological resistance independent Inflammation inhibit innate immune cell interferon Lung injury mutated Mutation Non-synonymous ORF ORF1b Pathogenesis patients Perspective Protein provided receptor Recombination recruit Replication RNA RNA genome SARS-CoV SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 vaccine specific mutation Spread strain structures suppress the spike protein translation understanding Vaccine Vaccines Viral RNA viral RNA synthesis virion virus virus entry Virus evolution virus infection [DOI] 10.1590/1414-431X202010725 PMC 바로가기 [Article Type] Review
Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen박쥐에서 SARS-CoV-2의 진화에서 자연 선택은 일반 바이러스와 고도로 유능한 인간 병원체를 만들었습니다Research Article Published on 2021-03-122022-08-13 Journal: PLoS Biology [Category] Biology and Life Sciences, Fulltext, SARS, 유전자 메커니즘, 조류인플루엔자, 치료기술, [키워드] accompanied acting acute respiratory syndrome coronavirus adaptive Analysis ancestor Anti-viral Antiviral base bat bat Sarbecovirus bats can not Cell Coinfection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CpG CpG composition detect early phase Evidence evidence of Evolution Evolution of SARS-CoV-2 horseshoe bats Host hosts Human human pathogen humans include involved Lineage lineages mechanism moderate natural natural selection nucleotide nucleotides pandemic positive Positive selection progenitor recombinant Recombination required respiratory reveal RmYN02 Sarbecoviruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support the cells the early SARS-CoV-2 Transmission virus viruses while [DOI] 10.1371/journal.pbio.3001115 PMC 바로가기 [Article Type] Research Article
Original Antigenic Sin: the Downside of Immunological Memory and Implications for COVID-19Opinion/Hypothesis Published on 2021-03-102022-10-30 Journal: mSphere [Category] COVID-19, SARS, [키워드] activated Affect Affinity maturation alphacoronavirus Anderson Antibody Response Antigen antigenic antigens B cell B cells Betacoronavirus COVID-19 COVID-19 pandemic elicited explain Germinal center germinal center reaction HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs highlight human coronavirus humoral Humoral immunity Immunity Imprinting include Infection memory B cell memory response Memory responses OAS original original antigenic sin outcome Recombination SARS-CoV-2 Science unique vaccination Vaccines [DOI] 10.1128/mSphere.00056-21 PMC 바로가기 [Article Type] Opinion/Hypothesis