Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaquesOriginal Article Published on 2015-09-292024-09-04 Journal: Clinical and experimental immunology [Category] 대상포진, [키워드] Anti-thymocyte globulin CD3 immunotoxin immune system irradiation Janus activated kinase inhibitor simian varicella virus Prednisone rhesus macaque tacrolimus [DOI] 10.1111/cei.12646 PMC 바로가기 [Article Type] Original Article
A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primatesArticle Published on 2015-09-042022-11-01 Journal: Science Translational Medicine [Category] Coronavirus, [키워드] acute respiratory syndrome antigen-specific neutralizing antibody antiviral therapy approved Arabian Peninsula cause caused cellular immunity characteristic Consensus coronavirus deaths disease DNA vaccine Europe exhibited increase in induce Infection lack Lineage macaque macaques MERS MERS coronavirus MERS spike protein MERS-CoV mice Middle East morbidity Mortality nosocomial pathogen Pneumonia Prevent protective immunity protective response Protein Radiographic respiratory syndrome coronavirus rhesus macaque route of infection SARS-CoV seroconverted syndrome The United States Transmission treat Vaccine viral challenge virus-neutralizing [DOI] 10.1126/scitranslmed.aac7462 PMC 바로가기 [Article Type] Article
Evaluation of candidate vaccine approaches for MERS-CoVArticle Published on 2015-07-282022-10-29 Journal: Nature Communications [Category] Coronavirus, MERS, [키워드] Analysis antibodies approach atomic candidate vaccine complex Computerized tomography CoV demonstrated DNA effective elicit full-length S glycoprotein highlight immunization immunogen information Isolation mechanism MERS-CoV mice Middle East monoclonal antibody Multiple murine NAb neutralization neutralizing antibody non-human primates Pneumonia Protein Radiographic RBD respiratory syndrome coronavirus responses rhesus macaque robust S variant S1 and S2 S1 subunit Sequencing serological assays severe respiratory disease spike strain subunit supplementary material the receptor-binding domain Vaccine Vaccine development Vaccines viral infection Virology virus [DOI] 10.1038/ncomms8712 PMC 바로가기 [Article Type] Article
Bacterial artificial chromosome derived simian varicella virus is pathogenic in vivoResearch Published on 2013-09-082023-05-24 Journal: Virology Journal [Category] Fulltext, 두창, 수두, 홍역, [키워드] bacterial artificial chromosome herpesvirus Pathogenesis rhesus macaque Simian varicella virus [DOI] 10.1186/1743-422X-10-278 PMC 바로가기 [Article Type] Research