Serial computed tomography findings of Coronavirus disease 2019 (COVID-19) pneumonia treated with favipiravir and steroid therapy: report of 11 casesResearch Published on 2021-05-192022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] absorbed addition Computed tomography consolidation Coronavirus disease 2019 correlated Course COVID-19 CT finding discharge evaluated Favipiravir Follow-up GGO Ground-glass opacities ground-glass opacity intubation lesion Manifestations mechanical ventilation onset of symptom Patient patients with COVID-19 Pneumonia predominant reduce required Result Severe COVID-19 pneumonia significantly starting steroid subpleural symptoms onset the patient therapy treated [DOI] 10.1186/s42269-021-00553-7 PMC 바로가기 [Article Type] Research
Randomized clinical trial to evaluate safety and efficacy of convalescent plasma use among hospitalized patients with COVID-19 (PERUCONPLASMA): a structured summary of a study protocol for a randomized controlled trial입원 중인 COVID-19 환자의 회복기 혈장 사용의 안전성과 효능을 평가하기 위한 무작위 임상 시험(PERUCONPLASMA): 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-05-172022-09-01 Journal: Trials [Category] SARS, 임상, 진단, 치료기술, [키워드] 1:1 ABO blood type Acute coronary syndrome administration Adverse reaction Adverse reactions aliquot Aliquots All participants allocation anaphylaxis antibody Antigen assessment Bilirubin Blinding block blocks blood gas blood gas analysis blood type C-reactive protein calculated Capacity carried case report form clinical clinical trial clinical trials Coagulation Coma completion confidence level congestive heart failure contraindication control group convalescent plasma coronary syndrome COVID-19 COVID-19 disease COVID-19 pneumonia creatinine Critical Critical disease CRP current D-dimer decrease defined detect Diagnosis dialysis disease Disseminated intravascular coagulation dissemination Donor donors drop Duration Dynamics eCRF Efficacy electronic case report form element eligible enrolled enrolment etiology evaluate evaluated events Evolution exclusion criteria expected experimental group exploratory failure following gas analysis hemodynamic instability hemorrhage hospital hospital discharge Hospitalization Hospitalized hospitalized patient hospitalized patients Hypothesis Hypoxemia ICU IIb in-hospital mortality Inclusion Infarction Inflammatory information Informed consent intensive care intensive care unit Intervention intracranial hemorrhage intravascular coagulation Invasive mechanical ventilation investigator investigators jaundice Laboratory laboratory confirmation Laboratory test Lactate lactate dehydrogenase Length less Local lymphocyte male marker Mechanical mechanical ventilation mmHg molecular Mortality multi-organ failure Myocardial infarction Neutralizing antibodies number objective occur Older open open label outcome oxygen Oxygen requirement oxygen saturation PaO participant Patient performed plasma Platelets Pneumonia power power of 80% previous diagnosis Probability protocol Public Hospital public hospitals quantification randomization Randomized Randomized controlled trial rationale receive reduce reducing reduction Registered resolution of symptom respiratory respiratory rate routine clinical practice Safe Safety Sample size SARS-COV-2 infection score Secondary objectives serious adverse reaction Serious adverse reactions serologic serum serum creatinine severe COVID-19 Severe COVID-19 pneumonia severe disease SOFA specific type standard treatment standard treatment alone statistical analysis Study protocol Stupor subject supplementary material Total total bilirubin transfusion treatment arm Trial uncontrolled vasopressors Ventilation website with COVID-19 [DOI] 10.1186/s13063-021-05189-6 PMC 바로가기 [Article Type] Letter
Gastrointestinal perforation secondary to COVID-19 Case reports and literature review4900 Published on 2021-05-142022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] abdomen abdominal pain Acute abdomen acute diverticulitis association bleeding Candidemia Case report cecal mass clinical condition clinician Corona virus corona virus disease-2019 Course COVID-19 Critical Diaphragm diarrhoea discharged fatal complication Gastrointestinal gastrointestinal involvement gastrointestinal perforation Gastrointestinal symptom highlight hospital IMPROVE intensive care intubation literature review mechanical ventilation nausea obese outcome pandemic Pneumonia radiological reported required respiratory manifestation respiratory symptoms sealed Severe COVID-19 pneumonia Symptom tomography transfer treated Two patient vomiting with COVID-19 [DOI] 10.1097/MD.0000000000025771 PMC 바로가기 [Article Type] 4900
Pneumomediastinum in a patient with COVID-19 due to diffuse alveolar damageCase Report Published on 2021-05-112022-10-28 Journal: BMJ case reports [Category] Coronavirus, Fulltext, SARS, [키워드] air leaks alveolar damage COVID-19 Diffuse alveolar damage Dyspnoea HFNC nasal no increase observation patient with COVID-19 Pneumomediastinum Positive end-expiratory pressure receiving Severe COVID-19 pneumonia supplemental oxygen Symptoms Thorax Treatment with COVID-19 [DOI] 10.1136/bcr-2021-242527 PMC 바로가기 [Article Type] Case Report
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity Research Published on 2021-05-102022-10-05 Journal: Nature cell biology [Category] 바이오마커, 치료기술, [키워드] Admission Antigen presentation antigen-presenting cell Antiviral antiviral immunity APC APCS Blood COVID-19 dataset DCs decrease dendritic cell DHX36 downregulation effector explain healthy donors High-resolution histocompatibility complex immune inflammatory mediator intensive care interferon-stimulated gene life-threatening mechanism MHC MHC class monocyte pathway Patient patients with moderate pDC pDCs plasmacytoid DC pro-apoptotic Respiratory failure reveal RNA sequencing severe COVID-19 Severe COVID-19 pneumonia Single-cell RNA-sequencing subset TLR9 unique Viral load [DOI] 10.1038/s41556-021-00681-2 [Article Type] Research
Off-label tocilizumab and adjuvant iron chelator effectiveness in a group of severe COVID-19 pneumonia patients: A single center experience중증 COVID-19 폐렴 환자 그룹에서 오프라벨 토실리주맙 및 보조제 철 킬레이터 효과: 단일 센터 경험Observational Study Published on 2021-05-072022-09-12 Journal: Medicine [Category] SARS, 임상, 진단, [키워드] acute respiratory syndrome adjuvant analyzed antibody Better center Chinese Comorbidities Comorbidity consecutive patients contribute Control coronavirus disease Coronavirus-2 corticosteroid therapy COVID-19 Critical Critical case Critically ill CRS Cytokine release syndrome death defined effective Effectiveness Emergency enrolled Evolution female ferritin Glucose had no hospital Hydroxychloroquine IL-6 receptor Invasive mechanical ventilation less male monoclonal Noninvasive ventilation occurred off-label outcome oxygen oxygen saturation Patient Pneumonia prevention rapid increase Romania SARS-CoV-2 SARS-COV-2 infection selected serum serum ferritin level Serum level Severe COVID-19 pneumonia severe pneumonia Side effect single center standard care TCZ Tocilizumab treated younger patients [DOI] 10.1097/MD.0000000000025832 PMC 바로가기 [Article Type] Observational Study
Impact of high dose of baricitinib in severe COVID-19 pneumonia: a prospective cohort study in Bangladesh중증 COVID-19 폐렴에서 고용량 바리시티닙의 영향: 방글라데시의 전향적 코호트 연구Clinical Trial Published on 2021-05-072022-08-13 Journal: BMC Infectious Diseases [Category] 임상, [키워드] 30-Day mortality 60-day rehospitalization rate Baricitinib Blood oxygen saturation level Clinical outcome clinical outcomes conducted COVID-19 infection COVID-19 pneumonia Critical care Cytokine storm declined functions groups HD group High dose hyperinflammation ICU Impact increase inflammatory cascade inflammatory cascades inhibitor intensive care intensive care unit intubation intubation support janus kinase kinases Mortality mortality rate oxygen oxygen saturation Patient prospective cohort study reduced rehospitalization required Respiratory failure respiratory functions Result risk room air severe COVID-19 Severe COVID-19 Infection Severe COVID-19 pneumonia suppress UD group Usual dose with COVID-19 [DOI] 10.1186/s12879-021-06119-2 PMC 바로가기 [Article Type] Clinical Trial
Successful Management of COVID-19 Infection in 2 Early Post-Liver Transplant Recipients간 이식 후 조기 수혜자 2명의 성공적인 COVID-19 감염 관리Case Reports Published on 2021-05-012022-09-11 Journal: Transplantation proceedings [Category] SARS, 진단, 치료제, [키워드] administration affected Clinical course clinical feature Clinical features Comorbidities convalescent plasma coronavirus disease Coronavirus disease 2019 Corticosteroids Course COVID-19 COVID-19 infection COVID-19 patients COVID-19 pneumonia Critical current described description dose reduction Future global mortality help hospital Hospitalization Hydroxychloroquine Immunosuppression include increased risk Infection life liver liver transplant Liver transplantation low-dose management Methylprednisolone monoclonal antibodies morbidity morbidity and mortality mortality rate MOST organ Organ transplant organ transplantation organ transplants Patient patients patients with comorbidities patients with COVID-19 Preliminary data Prognosis recipient recipients Remdesivir Research Respiratory care Severe COVID-19 pneumonia suggested table Tocilizumab Transplant treated Treatment treatment of COVID-19 Two patient two patients vaccination vulnerability [DOI] 10.1016/j.transproceed.2021.03.010 PMC 바로가기 [Article Type] Case Reports
Clinical course, radiological findings and late outcome in preterm infant with suspected vertical transmission born to a mother with severe COVID-19 pneumonia: a case report중증 코로나19 폐렴 산모에게서 태어난 수직감염 의심 미숙아의 임상 경과, 방사선 소견 및 후기 예후: 증례 보고Case Reports Published on 2021-04-232022-09-12 Journal: Journal of Medical Case Reports [Category] MERS, 진단, [키워드] 24 hour 24 hours acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age amniotic Amniotic fluid Birth Case report Chain Reaction clinical Clinical course complications coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 infection COVID-19 pneumonia died disease severity early-onset Infant infection with SARS-CoV-2 morbidity Mortality mother Neonatal Neonate newborn infant outcome PCR assay Pharyngeal swab polymerase chain polymerase chain reaction positive result pregnant women Preterm infant radiological finding Real-Time Reverse Transcription Polymerase Chain Reaction reverse transcription reverse transcription polymerase chain reaction RT-PCR RT-PCR assay SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe cases severe COVID-19 Severe COVID-19 pneumonia Transmission vertical transmission [DOI] 10.1186/s13256-021-02835-0 PMC 바로가기 [Article Type] Case Reports
RBD-specific polyclonal F(ab´)2 fragments of equine antibodies in patients with moderate to severe COVID-19 disease: A randomized, multicenter, double-blind, placebo-controlled, adaptive phase 2/3 clinical trialResearch article Published on 2021-04-142022-10-05 Journal: EClinicalMedicine [Category] 임상, [키워드] 95% CI adaptive Adverse age anaphylaxis antibodies antibody assigned baseline blinded category Clinical improvement clinical scale clinical trial conducted dose double-blind Efficacy and safety Endpoint enrolled equine event finding Follow-up hazard ratio hospital hospital discharge Hospitalized hospitalized patient Immunotherapy interquartile range male Mild moderate disease Mortality multicenter neutralizing antibody Patient patients with COVID-19 patients with moderate phase 2/3 Placebo placebo-controlled placebo-controlled trial polyclonal polyclonal antibody primary endpoint Randomized Rate reached receive reported risk SARS-CoV-2 SARS-CoV-2 pneumonia severe COVID-19 Severe COVID-19 pneumonia severe disease Severe patient significantly higher statistically statistically significant difference study group subgroup analysis symptoms onset the placebo group the primary endpoint therapeutic time Treatment WHO [DOI] 10.1016/j.eclinm.2021.100843 [Article Type] Research article