Safety and Immunogenicity of mRNA Vaccines Against Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Lung Cancer Receiving Immune Checkpoint Inhibitors: A Multicenter Observational Study in JapanObservational Study Published on 2022-08-012022-10-05 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome adverse event Against Anti-spike antibody assumed Cancer conducted controls coronavirus coronavirus 2 COVID-19 Efficacy enrolled hospital Immune checkpoint inhibitor Immune checkpoint inhibitors Immune-related adverse event immunogenicity Immunoglobulin incidence interquartile range irAE irAEs Japan lung cancer median age mRNA mRNA vaccine multicenter observational study nine Patient postvaccination predicted primary end point respiratory risk Safety SARS-CoV-2 seroconverted Seven significantly lower the patient treated vaccination vaccination rate vaccine immunogenicity [DOI] 10.1016/j.jtho.2022.05.015 PMC 바로가기 [Article Type] Observational Study
Are lipid ratios and triglyceride-glucose index associated with critical care outcomes in COVID-19 patients?지질 비율과 트리글리세리드-글루코스 지수는 COVID-19 환자의 중환자 치료 결과와 관련이 있습니까?Article Published on 2022-08-012022-09-11 Journal: PLoS ONE [Category] 바이오마커, [키워드] adjusted age Analysis biochemical marker biochemical markers BMI carried cholesterol coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 COVID-19 mortality COVID-19 patient Critical care demonstrated evaluate Glucose HDL-C high-density insulin insulin resistance LDL-C Lipid lipoprotein Logistic regression analysis low-density Low-density lipoprotein Mortality multivariate multivariate logistic regression analysis outcome performed predictor Prognosis Regression regression models Research severe coronavirus disease Severe patient severe patients severity Sex significantly higher significantly lower statistically survivor Total cholesterol Triglyceride with COVID-19 [DOI] 10.1371/journal.pone.0272000 PMC 바로가기 [Article Type] Article
Aromatherapy blend of thyme, orange, clove bud, and frankincense boosts energy levels in post-COVID-19 female patients: A randomized, double-blinded, placebo controlled clinical trialRandomized Controlled Trial Published on 2022-08-012022-10-05 Journal: Complementary therapies in medicine [Category] SARS, 임상, [키워드] acute COVID-19 acute infection Analysis aromatherapy assigned baseline BMI boost conducted Controlled clinical trial COVID-19 Diagnosis double blind double-blinded effect size employment Essential evaluate Evidence fatigue female FIVE group healthy IMPROVE individual Infection Inhaled Insomnia Intervention inventory lack Mental Oil olfactory function outcome Placebo placebo controlled trial proportion provide Quality of life Randomized recovering from COVID-19 secondary serious complication significantly significantly lower survivor Symptom the United State USA Utah were measured women [DOI] 10.1016/j.ctim.2022.102823 PMC 바로가기 [Article Type] Randomized Controlled Trial
A randomized, controlled, blinded, parallel group, clinical trial to study the role of Ayurcov (AyurCoro3), one day regimen as an adjuvant therapy for COVID-19 disease management, at dedicated Covid Hospital (DCH) in India인도의 코비드 전용 병원(DCH)에서 COVID-19 질병 관리를 위한 보조 요법으로서 Ayurcov(AyurCoro3)의 역할을 연구하기 위한 무작위, 통제, 맹검, 병렬 그룹 임상 시험Randomized Controlled Trial Published on 2022-08-012022-09-11 Journal: Complementary therapies in medicine [Category] SARS, 임상, 치료제, [키워드] adjuvant adverse events alternative medicine alum Antiviral Ayurcov Ayurveda blinded CAM carried Chain Reaction clinical trial complementary Complementary and alternative medicine. control group Controlled trial COVID-19 COVID-19 disease COVID-19 infections Ct values Curcuma Day diagnosed discharge disease dose evaluate Formulation functional Functional status higher risk India ingredient Limited management Mild mild to moderate Mild-to-moderate milk moderate outcome parallel group Patient polymerase chain polymerase chain reaction proportion Randomized real time receiving recruited reduction in regimen resolution of symptom reverse transcriptase Reverse transcriptase polymerase chain reaction Rock Candy rRT-PCR severe COVID-19 disease Severe COVID-19 Infection severe symptoms severity significantly significantly lower significantly more Sita Standard of care Symptom symptom resolution therapeutic effect therapeutic options therapy for COVID-19 transcriptase Treatment Urine [DOI] 10.1016/j.ctim.2022.102824 PMC 바로가기 [Article Type] Randomized Controlled Trial
Use of heated tobacco products, moderate alcohol drinking, and anti-SARS-CoV-2 IgG antibody titers after BNT162b2 vaccination among Japanese healthcare workers일본 의료 종사자의 BNT162b2 예방 접종 후 가열 담배 제품, 적당한 음주 및 항 SARS-CoV-2 IgG 항체 역가 사용Article Published on 2022-08-012022-09-12 Journal: Preventive medicine [Category] MERS, 진단, [키워드] addition alcohol alcohol consumption Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 IgG antibody Antibody titer association BNT162b2 BNT162b2 vaccine collected coronavirus disease covariates COVID-19 COVID-19 vaccine enzyme geometric mean titer GMT group healthcare worker Heated tobacco products IgG antibody titer immunoassay immunogenicity Immunological response Japan Japanese Linear regression model moderate National participant predictor questionnaire receiving reduction Research Result second vaccination serum significantly lower smoker smoking spike IgG the median vaccination Vaccine vaccine dose were assessed were measured were used [DOI] 10.1016/j.ypmed.2022.107123 PMC 바로가기 [Article Type] Article
Antibody responses to the SARS-CoV-2 vaccines in hemodialysis patients: Is inactivated vaccine effective?혈액투석 환자에서 SARS-CoV-2 백신에 대한 항체 반응: 불활성화 백신이 효과적인가?Article Published on 2022-08-012022-09-11 Journal: Therapeutic apheresis and dialysis : official peer [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody antibody level antibody levels Antibody Response carried Comparative control group COVID-19 detected antibody dose Effectiveness General population generate healthy volunteers Hemodialysis humoral Humoral response humoral responses immunization inactivated Inactivated vaccine investigated Maintenance hemodialysis mRNA mRNA vaccine mRNA vaccines Patient patients Receptor binding domain reduced SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seropositivity significantly lower Spike protein symptomatic infection the SARS-CoV-2 Vaccine vaccine group Vaccines were measured while [DOI] 10.1111/1744-9987.13752 PMC 바로가기 [Article Type] Article
Impaired humoral and cellular response to primary COVID-19 vaccination in patients less than 2 years after allogeneic bone marrow transplant동종 골수 이식 후 2년 미만의 환자에서 1차 COVID-19 예방 접종에 대한 체액 및 세포 반응 손상Article Published on 2022-08-012022-09-11 Journal: British Journal of Haematology [Category] MERS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adverse outcome adverse outcomes Allogeneic allogeneic bone marrow transplant analysed anti-S IgG Anti-spike BNT162b2 Bone marrow booster Cell Cell-mediated immunity cellular response ChAdOx1 Cohort coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) Coronavirus-2 COVID-19 COVID-19 vaccination Critical defined enzyme-linked immunospot Evidence evidence of haematopoietic stem cell transplant (HSCT) HCs healthy control high risk HSCT HSCT recipient HSCT recipients humoral IFNγ IgG Immunoglobulin Immunoglobulin G ImmunoSpot Impaired interferon less majority Patient Prophylactic prophylactic measure prophylactic measures rate of seroconversion recipient respiratory responders Seroconversion Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) significantly higher significantly lower stem cell T-cell T-cell Response T-cell responses These data titre Transplant vaccination schedule Vaccination strategy Vaccine vaccine immunogenicity Vaccines variants [DOI] 10.1111/bjh.18312 PMC 바로가기 [Article Type] Article
Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cellsOmicron이 아닌 조상 SARS-CoV-2는 일차 소아 비강 상피 세포에서 덜 효율적으로 복제합니다Article Published on 2022-08-012022-09-11 Journal: PLoS Biology [Category] Coronavirus, SARS, 변종, [키워드] acute respiratory syndrome Adults Air-liquid interface antiviral response Biology biology of SARS-CoV-2 changes in children coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Delta delta variant epithelial cells Evidence Infection infections less Mild symptom nasal epithelial cell nasal epithelium NEC NECs omicron pediatric replicate replicated Replication respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly lower Support susceptible These data vaccination Viral RNA virus VOCs widespread [DOI] 10.1371/journal.pbio.3001728 PMC 바로가기 [Article Type] Article
Senicapoc treatment in COVID-19 patients with severe respiratory insufficiency-A randomized, open-label, phase II trialClinical Trial Published on 2022-08-012022-10-05 Journal: Acta Anaesthesiologica Scandinavica [Category] COVID19(2023년), SARS, 임상, [키워드] 28-day mortality 95% CI Administered ARDS baseline Characteristics Concentration control group COVID-19 COVID-19 patient Denmark determine ICU IMPROVE intensive care unit Intervention IQR kPa mean difference median no difference Open-label outcomes PaO Patient patients with COVID-19 Primary outcome randomization Randomized respiratory insufficiency SARS-CoV-2 Senicapoc significantly lower standard care Treatment Trial Ventilation [DOI] 10.1111/aas.14072 PMC 바로가기 [Article Type] Clinical Trial
The clinical efficacy and safety of mesenchymal stromal cells for patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials코로나19 환자를 위한 중간엽 기질세포의 임상적 효능 및 안전성: 무작위 대조 시험의 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-08-012022-09-11 Journal: Journal of infection and public health [Category] 신약개발, 임상, [키워드] 28-day mortality 95% CI addition adverse event adverse events AEs appear Clinical efficacy Clinical improvement Clinical outcome clinical outcomes ClinicalTrials Cochrane Library control group controls COVID-19 help IMPROVE investigated Mesenchymal stromal cell Mesenchymal stromal cells Meta-analysis Mortality mortality rate MSC MSCs OVID Patient patients patients with COVID-19 Placebo placebos Randomized controlled trial Randomized controlled trials RCT RCTs risk Safe SARS-CoV-2 searched serious AE serious AEs significantly higher significantly lower stromal cell stromal cells systematic review therapeutic option treat Treatment [DOI] 10.1016/j.jiph.2022.07.001 PMC 바로가기 [Article Type] Meta-Analysis