Assembly of Biomolecular Gigastructures and Visualization with the Vulkan Graphics APIArticle Published on 2021-09-162022-10-29 Journal: Journal of Chemical Information and Modeling [Category] COVID-19, MERS, SARS, [키워드] Algorithm API assembly automated block bouton building can be used cells conformations Creative Common displaying downloaded Essential Giant GPU Graphics HIV implementation introduced limit memory molecular Molecular dynamics simulation platform presynaptic reduce reduced required SARS-CoV-2 significantly Structure structures View virus particle Visualization [DOI] 10.1021/acs.jcim.1c00743 PMC 바로가기 [Article Type] Article
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basisACE2의 S19W, T27W 및 N330Y 돌연변이는 SARS-CoV-2 S-RBD가 야생형 및 항체 내성 바이러스에 대한 결합과 분자 기반을 강화합니다.Article Published on 2021-09-162022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, [키워드] ACE2 angiotensin binding biochemical Clinical treatment clinical treatment of COVID-19 contributed COVID-19 decoy Efficacy elevated ENhance human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 Infection Interaction molecular basis Molecular biology mutant Mutation Protein pseudotyped SARS-CoV-2 RBD binding residue S-RBD SARS-CoV-2 shown spike receptor-binding domain steric structural biology Structure structures Substitution van der Waal van der Waals interactions virus viruses while wild-type [DOI] 10.1038/s41392-021-00756-4 PMC 바로가기 [Article Type] Article
Concise Update on Genomics of COVID-19: Approach to Its latest Mutations, Escalated Contagiousness, and Vaccine ResistanceReview Article Published on 2021-09-152022-10-31 Journal: Global Medical Genetics [Category] COVID-19, [키워드] acute respiratory distress Amino acid calreticulin canonical cause caused Cell changes in Chinese Clinical features complex connection coronavirus COVID-19 COVID-19 pandemic diagnostics Epidemiology genomic Genomics genomics of virus help histocompatibility complex Host hydrophobicity immune system Infectious disease inhibit intrinsic less membrane MHC-I Modification molecular multifunctional N-linked glycosylation Novel coronavirus novel coronavirus disease Nsp7 nucleus oligosaccharide outlined pandemic positive Protein proteomics Replication rate resistance response RNA genome SARS-CoV-2 sequence STAT structures syndrome transcription factor transfer translocated Treatment Vaccine development viral outbreak Viral protein virus [DOI] 10.1055/s-0041-1725143 PMC 바로가기 [Article Type] Review Article
SARS‐CoV‐2 structural coverage map reveals viral protein assembly, mimicry, and hijacking mechanismsArticle Published on 2021-09-142022-10-31 Journal: Molecular Systems Biology [Category] COVID-19, SARS, [키워드] 3D model 3D structure bioinformatics can be used complex Coronavirus infection Coverage COVID‐19 Data visualization forms help Host human proteins implicated knowledge mechanism Methods & Resources Microbiology, Virology & Host Pathogen Interaction modifications proteome provide provided resource resulting reveal SARS‐CoV‐2 SARS‐CoV‐2 proteins SARS‐CoV‐2 structural biology structures translation Viral protein viral replication [DOI] 10.15252/msb.202010079 PMC 바로가기 [Article Type] Article
Just Seeing Is Not Enough for Believing: Immunolabelling as Indisputable Proof of SARS-CoV-2 Virions in Infected Tissue단지 보는 것만으로는 충분하지 않습니다.Article Published on 2021-09-132022-09-10 Journal: Viruses [Category] SARS, 변종, 치료법, [키워드] analysed approach Cell cells correlative microscopy electron microscopy Enough Evidence followed by IHC Immunoelectron microscopy immunohistochemistry immunolabelling light microscopy methodological Microscopy morphology nasopharyngeal Nucleocapsid proteins paraffin-embedded pathologist Pathologists performed proof Protein SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virion SARS-CoV-2 virions Structure structures subsequent tissue transmission electron microscopy Ultrathin sections variant Viral viral particle virion virions [DOI] 10.3390/v13091816 PMC 바로가기 [Article Type] Article
A Bioluminescent 3CL Pro Activity Assay to Monitor SARS-CoV-2 Replication and Identify InhibitorsArticle Published on 2021-09-122022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] 3CL activity Anti-SARS-CoV-2 Activity Antiviral BAY2402234 Cell cell line cellular chemical screening cleavage site Compound Consensus coronavirus Coronaviruses Critical develop DHODH effective expressing expression firefly luciferase functional highlight identify inactive inhibitor inhibitors of SARS-CoV-2 IPPA-17-A04 NADPH oxidase Nasal Epithelial cells pandemic Prevent Pro protease quantification SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication Setanaxib structures therapeutic Therapeutic strategies Vidofludimus viral replication virus was used [DOI] 10.3390/v13091814 PMC 바로가기 [Article Type] Article
Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main ProteaseSARS-CoV-2 주요 프로테아제에 의한 다양한 바이러스 기질의 인식Article Published on 2021-09-102022-09-11 Journal: ACS Infectious Diseases [Category] Coronavirus, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid substitution amino acid substitutions antiviral drug catalysis catalytic changes in cleavage cleavage site cleave conserved coronavirus coronavirus disease Coronaviruses COVID-19 crystal structure crystal structures Efficiency ENhance homologous junction lifecycle M pro MPro NSP8 parameters peptide peptides polyprotein protease Proteases provide Recognition recognize Replication residue SARS-CoV-2 severe acute respiratory syndrome Coronavirus Structure structures substrate the SARS-CoV-2 unique viral nonstructural protein viral nonstructural proteins viral replication Virology Visualization [DOI] 10.1021/acsinfecdis.1c00237 PMC 바로가기 [Article Type] Article
SARS-CoV-2, Trait Anxiety, and the MicrobiomePsychiatry Published on 2021-09-082022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] Accuracy Activation Affect antibody Anxiety anxiety disorders Brain cause caused Central nervous system CNS Cognition cognitive COVID-19 COVID-19 pandemic Critical default mode network disease Effect effective Effects Efficiency elevated example Glutamate glutamic acid high-density homeostatic Host human host Immunity Immunological response immunological responses Infection information mechanism microbial Microbiome microbiota microglial modulating modulation neuronal pathology priming Research SARS-CoV-2 structures subsequent susceptibility Symptom toll-like receptor signaling Treatment turn viral infection virus [DOI] 10.3389/fpsyt.2021.720082 PMC 바로가기 [Article Type] Psychiatry
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variantsSARS-COV-2 수용체 결합 도메인 항체 인식의 구조적 및 에너지 프로파일 링 및 순환 변이체의 영향Research Article Published on 2021-09-072022-09-10 Journal: PLoS Computational Biology [Category] SARS, 변종, 진단, [키워드] affected Alpha Analysis antibody atomic Author B.1.1.7 B.1.617.2 binding binding domain circulating variant Clustering Community complex computational modeling Contact COVID-19 pandemic dataset Delta described determinant disrupt epitope epitope conservation evade feature group high resolution highlight identify immune response immune responses less molecular monoclonal antibodies monoclonal antibody Mutation mutations natural infection Neutralizing antibodies performed predicted Protective antibody protective antibody responses RBD Receptor binding domain Research residue residues SARS-CoV-2 pandemic SARS-CoV-2 receptor SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus spike glycoprotein Spread Structural analysis Structure structures target the SARS-CoV-2 the SARS-CoV-2 virus therapeutic Unsupervised clustering Vaccine Vaccine design Vaccines variants Viral viral variant Viral variants was used [DOI] 10.1371/journal.pcbi.1009380 PMC 바로가기 [Article Type] Research Article
Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design †Chemistry Published on 2021-09-062022-10-31 Journal: Chemical Science [Category] COVID-19, [키워드] analysed Analysis atomic level ATP binding binding pocket binding site catalytic function characterising complex conserved COVID-19 drug target enzyme Helicase highlight homologous identify inhibitor molecular non-structural protein performed provide RNA SARS-CoV-2 sequence specific inhibitor ssRNA structures subsequent substrate suggested treat viral replication [DOI] 10.1039/d1sc02775a PMC 바로가기 [Article Type] Chemistry