Subunit vaccine – Page 13 – Communicable Diseases Research

TLR4 Agonist Combined with Trivalent Protein JointS of Streptococcus suis Provides Immunological Protection in Animals

Article

Published on 2021-02-222024-09-02
Journal: Vaccines [Category] 대상포진,

[키워드] joints mice Piglet Streptococcus suis Subunit vaccine zebrafish
[DOI] 10.3390/vaccines9020184 PMC 바로가기 [Article Type] Article

High-level expression of the monomeric SARS-CoV-2 S protein RBD 320-537 in stably transfected CHO cells by the EEF1A1 -based plasmid vector

EEF1A1 기반 플라스미드 벡터에 의한 안정적으로 형질감염된 CHO 세포에서 단량체 SARS-CoV-2 S 단백질 RBD 320-537의 고수준 발현

Research Article

Published on 2021-02-022022-08-13
Journal: PLoS ONE [Category] Biochemistry, COVID-19,

[키워드] Accuracy acute respiratory syndrome Alpha amplification analyzed Antigen antigenic antigenic determinants C-terminal Cell culture cell line Chinese hamster CHO cell condition coronavirus coronavirus 2 Coronaviruses described determinant domain EEF1A1 elongation factor exceeded except for expression gel gel filtration Genetic Genome glycans glycosylation Host immune response inducer mammalian mass spectrometry methotrexate monomeric N-glycosylation peptide performed Plasmid PNGase F polyacrylamide polyacrylamide gel produced Protein purification RBD RBD protein recombinant Recombinant SARS-CoV-2 RBD reducing regulatory sequence regulatory sequences respiratory S protein S proteins SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S protein selected serological serological test Serological tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signal peptide subunit Subunit vaccine the S protein transfected cells translation unique Vaccine variant Viral viral envelope viral signal was obtained
[DOI] 10.1371/journal.pone.0242890 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 S1 is superior to the RBD as a COVID-19 subunit vaccine antigen

SARS-CoV-2 S1은 COVID-19 소단위 백신 항원으로서 RBD보다 우수합니다.

Article

Published on 2021-02-012022-09-12
Journal: Journal of medical virology [Category] MERS, SARS, 진단,

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

개코원숭이에서의 SARS-CoV-2 스파이크 당단백질 백신 후보 NVX-CoV2373 면역원성 및 마우스에서의 보호

Article

Published on 2021-01-142022-09-12
Journal: Nature Communications [Category] 비임상, 진단,

[키워드] angiotensin anti-S antibody anti-S IgG antibody Antigen Antigen-specific T cells B cell binding block CD4 CD8 clinical evaluation COVID-19 pandemic elicit elicited enzyme Evidence evidence of follicular full-length full-length spike protein functional Germinal center hACE2 hACE2 receptor helper T cell high affinity human Angiotensin-converting enzyme immunogenic immunogenicity low-dose Matrix-M mice multifunctional neutralize no evidence of NVX-CoV2373 prefusion conformation PROTECT Protective Protein Protein binding Protein vaccines receptor respiratory Respiratory disease S-protein Safe Saponin SARS-CoV-2 SARS-CoV-2 spike glycoprotein Spike protein spleen Spread subunit Subunit vaccine Support T cells Tfh Vaccine vaccine candidate virus virus infection
[DOI] 10.1038/s41467-020-20653-8 PMC 바로가기 [Article Type] Article

RBD-Fc-based COVID-19 vaccine candidate induces highly potent SARS-CoV-2 neutralizing antibody response

RBD-Fc 기반 COVID-19 백신 후보, 매우 강력한 SARS-CoV-2 중화 항체 반응 유도

Article

Published on 2020-11-272022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antigen Antisera binding caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccines CoVs domain dominant Economy effective Effective vaccines elicited Epitopes Fc fragment fragment of global health Health human ACE2 IgG immunization Immunopotentiator induce Infection infections live SARS-CoV-2 mice mutants natural mutation natural mutations neutralization neutralize Neutralizing activity neutralizing epitope pandemic Prevent PROTECT pseudotyped pseudotyped SARS-CoV-2 RBD RBD-Fc RBD-specific antibodies RBD-specific antibody receptor Receptor-binding domain respiratory responsible robust Safe SARS-CoV SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 neutralizing antibody SARS-CoV-2 RBD SARS-related coronavirus SARSr-CoV SARSr-CoVs severe acute respiratory syndrome Coronavirus specific antibodies Spike protein subunit Subunit vaccine the SARS-CoV-2 the spike protein threat transgenic mice Vaccine Vaccines
[DOI] 10.1038/s41392-020-00402-5 PMC 바로가기 [Article Type] Article

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment

내열성이 높은 면역원성 SARS-CoV-2 스파이크 단편의 설계

Research Article

Published on 2020-11-232022-09-12
Journal: The Journal of Biological Chemistry [Category] SARS, 진단,

[키워드] ACE2 antibodies AUC, area under the curve clinic clinical testing COVID-19 CPE, cytopathic effect Culture DMEM, Dulbecco's Modified Dulbecco's Medium ectodomain elicited Endpoint exposure to expressed extreme feature geometric mean geometric mean titer glycosylation guinea pig HRP, horseradish peroxidase IAEC, Institutional Animal Ethics committee IMAC, immobilized metal affinity chromatography immunogenic ingredient mammalian cell MF59 microbial monomeric mRNA Neutralizing antibodies neutralizing antibody NTD, N-terminal domain PBS, phosphate buffered saline PEI, polyethylenimine Pichia Protein subunit vaccines purified RBD RBD protein RBD, receptor-binding domain RBM, receptor binding motif Receptor-binding domain replicative SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 vaccine SEC, size-exclusion chromatography solution Spike protein subunit Subunit vaccine temperature the RBD the receptor-binding domain thermostable thermotolerance Vaccine viral spike protein Viral vector viral vectors virus
[DOI] 10.1074/jbc.RA120.016284 PMC 바로가기 [Article Type] Research Article

Rapid Response Subunit Vaccine Design in the Absence of Structural Information

구조적 정보가 없는 상황에서 신속한 반응 서브유닛 백신 설계

Immunology

Published on 2020-11-042022-09-11
Journal: Frontiers in Immunology [Category] 비임상,

Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Nanogel as a Pro-Antigen Strategy with Enhanced Protective Immune Responses

Article

Published on 2020-11-012023-07-11
Journal: Small (Weinheim an der Bergstrasse, Germany) [Category] SARS,

[키워드] Coronavirus disease-19 Nanogel Receptor binding domain severe acute respiratory syndrome coronavirus-2 Subunit vaccine
[DOI] 10.1002/smll.202004237 PMC 바로가기

Expression of immunogenic poliovirus Sabin type 1 VP proteins in transgenic tobacco

article

Published on 2020-10-312024-09-01
Journal: Journal of Biotechnology [Category] 폴리오,

[키워드] molecular farming mucosal immunity Oral vaccine Plant-made vaccine poliomyelitis Subunit vaccine
[Article Type] article

Enhanced elicitation of potent neutralizing antibodies by the SARS-CoV-2 spike receptor binding domain Fc fusion protein in mice

Article

Published on 2020-10-272023-07-11
Journal: Vaccine [Category] SARS,

[키워드] Cell–cell fusion assay Receptor-binding domain (RBD) SARS-CoV-2 Subunit vaccine
[DOI] 10.1016/j.vaccine.2020.09.058 PMC 바로가기