APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patientsAPOE는 ACE2와 상호작용하여 COVID-19 환자에서 SARS-CoV-2 세포 진입 및 염증을 억제합니다Article Published on 2022-08-012022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] ACE2 addition Affect allele ApoE APOE4 Apolipoprotein Apolipoprotein e assays binding binding affinity cardiovascular diseases carrier carriers cells cellular entry chemokine cholesterol cholesterol metabolism clinically comparable Concentration COVID-19 infection COVID-19 patient COVID-19 patients disease severity docking domain elevated explain genetic risk factor Infection Inflammation Inflammatory factor inhibit inhibiting interact Interaction isoform Lipid mechanism metabolism Protein receptor reduce Regulatory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein serum serum concentrations spike Spike protein susceptibility the SARS-CoV-2 transmission electron microscopy viral entry viruses Zinc [DOI] 10.1038/s41392-022-01118-4 PMC 바로가기 [Article Type] Article
Ovarian granulosa cells from women with PCOS express low levels of SARS-CoV-2 receptors and co-factorsPCOS가 있는 여성의 난소 과립막 세포는 낮은 수준의 SARS-CoV-2 수용체 및 보조 인자를 발현합니다Article Published on 2022-08-012022-09-11 Journal: Archives of gynecology and obstetrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus BSG cardiovascular disease Cell cell types co-morbidities controls coronavirus COVID-19 CTSB CTSL datasets death diabetes DPP4 Express expresse expression Factor feature global pandemic granulosa healthy help Human in vitro In vitro fertilization indicate Infection investigated IVF knowledge Lower lower expression material Microarray microarray data morbidities obesity Oocyte organ ovarian ovarian follicle Ovarian granulosa cells Ovary pandemic PCOS polycystic ovary protease receptor reproductive risk Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptibility susceptible syndrome tissue TMPRSS2 Type-2 diabetes mellitus women [DOI] 10.1007/s00404-022-06567-4 PMC 바로가기 [Article Type] Article
Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy Research Published on 2022-08-012022-10-05 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] approach association automatically Clinical data Combination complex Consensus COVID-19 severity disease severity Electronic health record Genetic genomes highest highlight HLA host genome impacted individual marker metagenomic Nasopharyngeal swab neurologic pandemic phenotype Population positive powerful tool Region reported reveal risk SARS-CoV-2 SARS-CoV-2 pandemic sequence severe COVID-19 susceptibility Transcriptome viral disease viral genome [DOI] 10.1038/s41467-022-32397-8 [Article Type] Research
Human genetic factors associated with pneumonia risk, a cue for COVID-19 susceptibility폐렴 위험과 관련된 인간 유전적 요인, COVID-19 감수성의 신호Meta-Analysis Published on 2022-08-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] Coronavirus, 변종, 유전자 메커니즘, [키워드] acquisition age airway epithelium Alter Analysis applied article association calculated case-control studies cause Community community acquired community acquired pneumonia contribute coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 susceptibility CYP1A1 driven by effect size Egger eligible evaluated expressed Factor funnel plot Genetic genetic etiology Genetic variant genetic variants healthy controls heterogeneity host genetics Human identify key factor likelihood Lung inflammation marker Maximum likelihood meta-analysed Meta-analysis Mortality nosocomial Nosocomial pneumonia Odds ratio Pathogenesis Patient performed Pneumonia Prevalence publication bias respiratory tract infection risk risk allele statistical significance subgroup analysis susceptibility Variability variant variants Viral pneumonia was performed were used [DOI] 10.1016/j.meegid.2022.105299 PMC 바로가기 [Article Type] Meta-Analysis
FURIN gene variants (rs6224/rs4702) as potential markers of death and cardiovascular traits in severe COVID-19심각한 COVID-19에서 사망 및 심혈관 특성의 잠재적 마커로서의 FURIN 유전자 변이체(rs6224/rs4702)Article Published on 2022-08-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] addition age allele association candidate Candidates cleaving COVID-19 COVID-19 patient COVID-19 patients death death case diabetes DNA variant DNA variants evaluated expression functional furin FURIN gene gene polymorphism Genotype genotyped Haplotype Homozygosis hypercholesterolemia hypercholesterolemia. hyperlipidaemia hypertension increased risk independent risk factor independent risk factors Infection infection cycle intensive care intensive care unit Logistic regression marker multiple logistic regression Odds ratio physiological protease regulate risk risk of death SARS-CoV-2 severe COVID-19 significantly significantly increased statistically susceptibility traits variant Viral protein Viral proteins virus [DOI] 10.1002/jmv.27748 PMC 바로가기 [Article Type] Article
Chapter Two: Biological underpinnings of sex differences in neurological disordersBook chapter Published on 2022-07-302022-10-05 Journal: International Review of Neurobiology [Category] 비임상, [키워드] addressed Biological Brain Brain-body communication complex contribute diagnostics Efficacy epigenetic mechanisms genetics heterogeneity increasingly mechanism molecular Neurological disease Neurological diseases Neurological disorder Prognosis remained Research response to treatments severity of symptoms sex chromosomes Sex difference sex differences Sex hormones Signaling susceptibility women [DOI] 10.1016/bs.irn.2022.06.009 [Article Type] Book chapter
Chromosomal-level reference genome assembly of the North American wolverine (Gulo gulo luscus): a resource for conservation genomics북미 울버린(Gulo gulo luscus)의 염색체 수준 참조 게놈 어셈블리: 보존 유전체학을 위한 리소스Article Published on 2022-07-292022-09-11 Journal: G3 (Bethesda, Md.) [Category] 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 aggression aggression genes aggressive behavior baseline Canada chromosomal-level assembly Climate change Complete conservation genomics contig coronavirus Coronavirus-2 Coronaviruses environmental disruption Final Genes Genetic Genome genome assembly genomes Gulo gulo Gulo gulo luscus heterozygous Infection innate immune system Innate immunity involved long-reads male management modality naïve North nucleotide Nunavut parasitic diseases Pathogens reference genome resource SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus shown Single nucleotide variant specimen Support susceptibility viral pathogen viral pathogens wolverine wolverine. [DOI] 10.1093/g3journal/jkac138 PMC 바로가기 [Article Type] Article
Unsuppressed HIV infection impairs T cell responses to SARS-CoV-2 infection and abrogates T cell cross-recognition억제되지 않은 HIV 감염은 SARS-CoV-2 감염에 대한 T 세포 반응을 손상시키고 T 세포 교차 인식을 폐지합니다Article Published on 2022-07-262022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] abrogate abrogation Beta Beta variant CD4 CD8 correlated COVID-19 disease COVID-19 epidemic Cytometry determine diminishe epitope epitope specificity explain First wave Flow flow cytometry greater highlight HIV HIV infection Human identify immunodominance immunology impair in some individual Infection Inflammation instances mechanism mononuclear cell Mutation peptide peptide pools Peripheral blood PLWH Protein Recognition SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants second wave severe COVID-19 severe COVID-19 disease significantly South Africa specificity Spike protein susceptibility T cell T cell activation T cell response T cell responses the Spike variant was used with HIV [DOI] 10.7554/eLife.78374 PMC 바로가기 [Article Type] Article
Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background miceFVB 배경 마우스에서 SARS-CoV-2 감염에 민감하고 내성이 있는 형질전환 모델 개발Article Published on 2022-07-262022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome coronavirus atrophy caused Cerebellum cerebrum coronavirus 2 coronavirus disease COVID-19 COVID-19 pandemic development disease exhibited Goblet cell goblet cells hACE2 histopathological finding histopathological findings hyperplasia K18-hACE2 K18-hACE2 mice lung Lungs mice Mild mild pneumonia overcome Pneumonia reduction respiratory SARS-CoV-2 SARS-COV-2 infection sensitivities Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe pneumonia small intestine spleen strain susceptibility susceptible Therapeutics transgenic mice transgenic model Vaccine viral titer weight loss White pulp [DOI] 10.1371/journal.pone.0272019 PMC 바로가기 [Article Type] Article
GDF15 and ACE2 stratify COVID-19 patients according to severity while ACE2 mutations increase infection susceptibilityGDF15 및 ACE2는 중증도에 따라 COVID-19 환자를 계층화하는 반면 ACE2 돌연변이는 감염 감수성을 증가시킵니다Article Published on 2022-07-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 characterized circulating Cohort coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient disease disease severity Early detection Effect Frequency GDF15 GDF5 global pandemic growth heterogeneous in vitro Infection Inflammation Mild Mild disease Missense Mutation mutations Patient plasma Prognosis risk factor sensitivity severity severity of COVID-19 SNP SNPs susceptibility uninfected control [DOI] 10.3389/fcimb.2022.942951 PMC 바로가기 [Article Type] Article