A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models자가 증폭 mRNA SARS-CoV-2 백신 후보는 전임상 모델에서 안전하고 강력한 보호 면역을 유도합니다Clinical Trial Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 임상, 진단, [키워드] (Alpha) (Beta Alpha animals Antigen B.1.1.7 B.1.351 B.1.617.2 Beta biodistribution breath CD4 CD8 T cell CD8 T cell responses characterized clinical evaluation Delta demonstrated disease dose-dependent manner Efficacy elicit elicited emergency response Evidence evidence of Frequency Germinal center hamsters humans immune responses immunization immunogenicity induce Lipid nanoparticle Lipid nanoparticles LNP lower airways Messenger RNA mice mRNA neutralized no evidence of Phase 1 Protective protective immune response protective immunity RATs reduced response RNA RNA vaccines robust Safe safety profile SAM SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants SARS-CoV-2 Wuhan strain self-amplifying mRNA Spike antigen spike-specific antibody response T cell the SARS-CoV-2 the vaccine Tolerance Toxicity upper and lower airways Vaccine vaccine candidate variants Viral Viral load Wuhan-Hu-1 [DOI] 10.1016/j.ymthe.2022.01.001 PMC 바로가기 [Article Type] Clinical Trial
Elucidating Design Principles for Engineering Cell-Derived Vesicles to Inhibit SARS-CoV-2 InfectionSARS-CoV-2 감염을 억제하기 위해 세포 유래 소포를 엔지니어링하기 위한 설계 원리 설명Article Published on 2022-05-012022-09-11 Journal: Small (Weinheim an der Bergstrasse, Germany) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition administration antiviral efficacy binding affinities clinic coronavirus decoy decoys develop drug resistance Engineering evade Extracellular Extracellular vesicles feature foundation Health inhibit inhibitor inhibitors knowledge mAb mAbs monoclonal antibody nanovesicles. neutralization overcome Particle pathogen Pathogens principle provide Quantitative Recombinant protein repeated respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 virions sera several variant several variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sustained Therapeutics therapy Toxicity Vesicle vesicles Viral viral infections virions [DOI] 10.1002/smll.202200125 PMC 바로가기 [Article Type] Article
Molnupiravir; molecular and functional descriptors of mitochondrial safety몰누피라비르; 미토콘드리아 안전성의 분자 및 기능 설명자Article Published on 2022-05-012022-09-11 Journal: Toxicology and applied pharmacology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] active form Adult patients Analyzer antiviral drug antiviral drugs approved arrest cell line Concentration concentrations copy number COVID-19 Culture cytotoxicity DNA polymerase dose drug emergency treatment Endpoint expression flux functional Genome HepG2 HepG2 cell incorporation inhibit lack mechanism metabolite Mitochondria mitochondrial mitochondrial DNA Mitochondrial function mitochondrial gene molecular molnupiravir Mutation N-hydroxycytidine NHC nucleoside Patient phenotypic PolG POLRMT progression RdRP replicating virus Replication resulting risk RNA polymerase significantly specificity the SARS-CoV-2 Toxicity Transcription Treatment triphosphate U.S. FDA viral genome virus was measured [DOI] 10.1016/j.taap.2022.116003 PMC 바로가기 [Article Type] Article
Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19QSAR, 분자 도킹, 분자 동적 시뮬레이션 및 MM-PBSA의 조합: COVID-19에 대한 잠재적 약물 후보로서 로피나비르 및 파비피라비르의 유사체Article Published on 2022-05-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption active site analogue Analysis anti-viral drug Anti-viral drugs binding affinity candidate Candidates Compound COVID-19 COVID-19 infection COVID-19 infections demonstrated disease distribution docked complex docking drug candidate druggability effective enzyme Enzymes Favipiravir feature form identify IMPROVE in vitro inhibit Interaction less Lopinavir M pro metabolism Modification molecular molecular docking molecular dynamic simulations molecular dynamics Molecular dynamics simulation novel drug physicochemical polyprotein polyproteins processing protease QSAR Quantitative RdRP Replication residue RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 selected shown significantly small molecule Small molecules Spread stable complex Toxicity trajectory translated Treatment Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1080/07391102.2020.1850355 PMC 바로가기 [Article Type] Article
Drug-resistant tuberculosis: advances in diagnosis and management약제내성결핵: 진단 및 관리의 발전Review Published on 2022-05-012022-09-11 Journal: Current opinion in pulmonary medicine [Category] MERS, 진단, 치료제, [키워드] accelerated bedaquiline benefit Care changes clinical trial complex Coverage COVID-19 pandemic Diagnosis diagnostic drug drug resistance drug-resistant drug-resistant tuberculosis drugs majority management mitigate molecular diagnostics Mycobacterium Mycobacterium tuberculosis Next-generation sequencing notable Occurrence recent reduce regimen rifampicin Spread Strains TB patient TB patients Toxicity Treatment Tuberculosis [DOI] 10.1097/MCP.0000000000000866 PMC 바로가기 [Article Type] Review
Shedding light on the toxicity of SARS-CoV-2-derived peptide in non-target COVID-19 organisms: A study involving inbred and outbred mice비표적 COVID-19 유기체에서 SARS-CoV-2 유래 펩타이드의 독성에 대한 조명: 근친교배 및 근친교배 마우스를 대상으로 한 연구Article Published on 2022-05-012022-09-11 Journal: Neurotoxicology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 유전자 메커니즘, [키워드] acetylcholinesterase activated administration alteration animals antidepressant antioxidant anxiolytic applied biochemical Biomarker Brain C57Bl/6 J mice catalase consequence COVID-19 demonstrated depressive dismutase dispersion Effect Environmental Toxicology evaluate evaluated Evidence evidence of exposure to Field test genetic profile greater homeostasis hydrogen hydrogen peroxide Impact Laboratory locomotor maintain male mammalian mechanism memory memory deficit mice natural environments open oxidative stress Pandemic COVID-19 PCA peptide Principal component principal component analysis Protein Proteins provide reactive reduction in Research response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 particle SARS-CoV-2 particles sensitivity shedding Spike protein Superoxide Superoxide Dismutase Swiss mice. the Spike the vaccine Therapeutic strategies therapeutic strategy Toxicity Viral [DOI] 10.1016/j.neuro.2022.03.012 PMC 바로가기 [Article Type] Article
Radiotherapy treatment interruptions during the Covid-19 pandemic: The UK experience and implications for radiobiology trainingResearch article Published on 2022-05-012022-10-05 Journal: Radiation Physics and Chemistry [Category] 치료법, [키워드] Cancer caused Cell Course COVID-19 dose Frequency help implication increase in involved likelihood morbidity occur offset pandemic Patient problem Quantitative Radiation radiobiology Radiotherapy Radiotherapy treatment interruptions required risk Self-isolation Spread tissue Toxicity Treatment [DOI] 10.1016/j.radphyschem.2022.110214 [Article Type] Research article
Lithium salts as a treatment for COVID-19: Pre-clinical outcomesCOVID-19 치료제로서의 리튬염: 전임상 결과Article Published on 2022-05-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 임상, 치료법, 치료제, [키워드] advance Anti-inflammatory anti-SARS-CoV-2 Antiviral antiviral properties antiviral property approach approved drug clinical trial clinical trials Concentration controls coronavirus disease Coronavirus disease 2019 COVID-19 disease dose-dependent manner Effect effective drug effective drugs Effects evaluate evaluated Evidence evidence of experiment glycogen glycogen synthase hamster hamsters identifying Inflammation inhibited less lithium lung Lungs microscopic observation Mortality N protein Nasopharyngeal swab nasopharyngeal swabs neutral red outcome patients Pre-clinical trial Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 virus significantly higher supernatant supernatants Support therapeutic effect Toxicity treated Treatment viral control Viral load virus [DOI] 10.1016/j.biopha.2022.112872 PMC 바로가기 [Article Type] Article
Imperative role of electron microscopy in toxicity assessment: A reviewReview Published on 2022-05-012023-07-07 Journal: Microscopy research and technique [Category] COVID19(2023년), [키워드] SARS CoV2 scanning electron microscopy Toxicity transmission electron microscopy ultrastructure [DOI] 10.1002/jemt.24029 [Article Type] Review
Digital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial Research Published on 2022-04-252022-10-05 Journal: Nature Medicine [Category] 임상, [키워드] 1:1 anticancer approved assessment Cancer cancer patient Care chronic Digital dose dose intensity duration of hospitalization evaluated experimental arm Follow-up Hospitalization illness IMPROVE Intervention offer outcome Patient Patient care patients treated Phase 3 phase 3 trial Quality of life Randomized receiving reduced remote monitoring remote monitoring system Secondary objective Strategy survival Symptom the patient toxicities Toxicity Treatment Trial usual care [DOI] 10.1038/s41591-022-01788-1 [Article Type] Research