Mapping molecular gene signatures mediated by SARS-COV-2 and large-scale and genome-wide transcriptomics comparative analysis among respiratory viruses of medical importanceComparative Study Published on 2022-04-302023-07-01 Journal: Molecular and cellular probes [Category] COVID19(2023년), SARS, [키워드] COVID-19 Influenza rhinovirus RSV SARS-CoV-1 SARS-CoV-2 transcriptomics [DOI] 10.1016/j.mcp.2022.101820 PMC 바로가기 [Article Type] Comparative Study
Analyzing single cell transcriptome data from severe COVID-19 patients중증 코로나19 환자의 단세포 전사체 데이터 분석Article Published on 2022-04-212022-09-11 Journal: STAR protocols [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] bioinformatics Cell cell type cell types cellular Complete COVID-19 COVID-19 severity database detect disease-associated enrichment analysis Gene Expression Genomics Health Sciences identify immunology in silico in vitro in vivo marker gene Molecular biology protocol Regulatory resources RNAseq severe COVID-19 severe COVID-19 patient Single Cell single-cell Transcriptome transcriptomics upregulated upregulation [DOI] 10.1016/j.xpro.2022.101379 PMC 바로가기 [Article Type] Article
Identifying Immunological and Clinical Predictors of COVID-19 Severity and Sequelae by Mathematical Modeling수학적 모델링을 통한 COVID-19 심각도 및 후유증의 면역학적 및 임상적 예측인자 식별Article Published on 2022-04-202022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] absolute neutrophil count Analysis Aritficial Intelligence biochemical biochemical markers Biochemical parameters Blood urea nitrogen C-reactive protein clinical Cohort control subject control subjects coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Critical curated cytokine Cytokines dataset differential expression disease severities Efficacy exploratory ferritin granzyme B highlight identify identifying IFN-γ IL-1 IL-10 IL-15 IL-1ra IL-6 immunological Increased Initially interferon Interferon-gamma interleukin investigated Lactate lactate dehydrogenase Liver injury machine machine learning methodology modeling multiplex Multiplex assay Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples Necrosis neutrophil nitrogen outcome pandemic pathophysiology pathway Patient PD-L1 potential therapeutic targets predict Predictive predictive models Predictive value predictor radiological receptor RNA RNA seq ROC ROC analysis serum severe cases severity the disease transcriptomics tumor necrosis urea validation cohort variant [DOI] 10.3389/fimmu.2022.865845 PMC 바로가기 [Article Type] Article
Clinical and translational values of spatial transcriptomics Reviews Published on 2022-04-012022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] alterations Analysis bioinformatics Biomarkers cellular interaction clinical Clinical practice Combination disadvantage evaluate Gene Expression highlight human disease human tissue Inflammation intercellular Interpretation knowledge molecular oncology Pathogenesis protocol RNA sequencing scRNA-seq Sequencing Single Cell spatiotemporal transcriptomics translate translational [DOI] 10.1038/s41392-022-00960-w [Article Type] Reviews
Computational identification of host genomic biomarkers highlighting their functions, pathways and regulators that influence SARS-CoV-2 infections and drug repurposingSARS-COV-2 감염 및 약물 용도에 영향을 미치는 기능, 경로 및 조절제를 강조하는 숙주 게놈 바이오 마커의 계산 식별Article Published on 2022-03-112022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 변종, 신약개발, 치료제, [키워드] 3CL Analysis analyzed binding affinities Biomarker candidate drugs Computational biology and bioinformatics control sample COVID-19 CXCL2 daclatasvir DEGs differentially expressed gene docking drug Drug discovery drug target drugs Economy effective enrichment analysis FDA approved Drugs function functional functions genomic GUCY1A2 highlighting Host hub-genes identify IGF2 independent indicate infections Interaction investigated IRF7 Ivermectin KEGG pathway KLF6 life miRNA miRNAs molecular docking analysis NEDD9 network analysis PAG1 pandemic pathway Pathways performed PPI Protein Protein–protein interaction Proteins Radotinib Rapamycin receptor receptor protein receptor proteins receptors reduced RNA sequence SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections Seven signaling pathway signaling pathways significantly SNRPD2 stability Stat1 Systems biology tacrolimus the SARS-CoV-2 Thiostrepton TLR2 transcriptomics Treatment USP53 vaccination variants of SARS-CoV-2 ZFP36 [DOI] 10.1038/s41598-022-08073-8 PMC 바로가기 [Article Type] Article
A blood atlas of COVID-19 defines hallmarks of disease severity and specificityArticle Published on 2022-03-032023-06-14 Journal: Cell [Category] MERS, SARS, [키워드] Blood coronavirus COVID-19 epigenetics immune Multi-omics Personalized medicine proteomics SARS-CoV-2 transcriptomics [DOI] 10.1016/j.cell.2022.01.012 PMC 바로가기
Differential gene expression reveals host factors for viral shedding variation in mallards ( Anas platyrhynchos) infected with low-pathogenic avian influenza virusArticle Published on 2022-03-012023-06-22 Journal: The Journal of General Virology [Category] 조류인플루엔자, [키워드] Influenza shedding transcriptomics virus [DOI] 10.1099/jgv.0.001724
Using Omics to Study Leprosy, Tuberculosis, and Other Mycobacterial Diseasesarticle Published on 2022-02-282024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 한센병, [키워드] Genomics leprosy Lipidomics metabolomics mycobacteria proteomics transcriptomics Tuberculosis [Article Type] article
Augmentation of Transcriptomic Data for Improved Classification of Patients with Respiratory Diseases of Viral Origin바이러스성 호흡기 질환 환자 분류 개선을 위한 전사 데이터의 증대Article Published on 2022-02-242022-09-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] Accuracy another respiratory virus approach augmentation Bacterial classification contribute criteria data augmentation dataset deep learning Diagnosis disease DNA microarray early diagnosis example Final gene-expression generative adversarial networks high-dimensional data IMPROVE Improved infected individual infected individuals machine machine-learning molecular molecular basis origin overfitting overlap Patient Predictor variables Prevent respiratory Respiratory disease respiratory diseases respiratory infectious disease respiratory virus reveal RNA-Seq RNA-seq data SARS-CoV-2 selected shown transcriptomic transcriptomic data transcriptomics variable Viral viral acute respiratory illness [DOI] 10.3390/ijms23052481 PMC 바로가기 [Article Type] Article
Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19Research article Published on 2022-02-232022-10-05 Journal: iScience [Category] 바이오마커, 변종, 유전자 메커니즘, [키워드] adaptive immune system circulating neutrophil cleavage cleaved clotting coagulation factor COVID-19 expressed expression Factor factor V form hospitalized patient identify immunofluorescence microscopy immunology in vitro Increased inhibitor leukocyte leukocytes liver Lung disease lymphopenia Microbiology Monocytes mononuclear cells mRNA Neutrophils omics Peripheral blood proliferation Proteomic analysis reduce RNAseq scRNAseq severe COVID-19 severe disease suppress T regulatory cell T-cell thrombin transcriptomics Whole blood with COVID-19 [DOI] 10.1016/j.isci.2022.103971 [Article Type] Research article