underlie – Page 13 – Communicable Diseases Research

Synaptogyrin-2 influences replication of Porcine circovirus 2

Synaptogyrin-2는 돼지 써코바이러스 2의 복제에 영향을 미칩니다

Research Article

Published on 2018-10-312022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

The nucleoid occlusion factor Noc controls DNA replication initiation in Staphylococcus aureus

nucleoid occlusion factor Noc는 황색 포도구균에서 DNA 복제 개시를 조절합니다

Research Article

Published on 2017-07-192022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis

Zebrafish slc30a10 결핍은 망간 항상성을 유지하는 Atp2c1의 새로운 보상 메커니즘을 밝혀냈습니다

Research Article

Published on 2017-07-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] absence accompanied accumulated activating adulthood approach ATP2C1 ATPase Author Brain can be used characterized cirrhosis cirrhosis) clinically CRISPR deficiency degenerative degenerative diseases develop disease Disease model disorder dysregulation dystonia early-onset EDTA effective Embryo embryonic ENCODE expressing expression fibrosis form HeLa cells hepatic injury homeostasis Impaired impaired function implicated inhibit iron liver Liver fibrosis manganese manganism mechanism metabolic disorder metabolism modulating mutant mutant embryo mutant embryos mutants Mutation neurological Neurological deficit neurological deficits neurological impairment pharmacological phenotype physiological polycythemia recent reduce rescued secretory pathway Signaling significantly higher SLC30A10 specific treatment steatosis therapy underlie wild-type zebrafish
[DOI] 10.1371/journal.pgen.1006892 PMC 바로가기 [Article Type] Research Article

A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides

비정규 RNA 분해 경로는 인간 곰팡이 병원체 Mucor circinelloides에서 RNAi 의존성 후성 돌연변이를 억제합니다

Research Article

Published on 2017-03-242022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] activate Activation animal hosts Antifungal treatment Community component Compound conditions Degradation described determined by Dicer drug target drug-resistant effective Efficacy emerging disease ENhance environmental condition environmental conditions expression FK506 fungal Fungal infection fungal pathogen fungal pathogens fungi generate genetic analysis growth Helicase Host host-pathogen interaction host-pathogen interactions Human include inhibitory inhibitory effect involved isolate isolates lack mechanism molecular mechanism mRNA degradation Mucor Mucorale Mucorales Mucormycosis Mutation non-canonical RNA pathogen Pathogens pathway performed phenotype phenotypic plasticity prevented previous study Prognosis Protein provided RdRP recent Regulation represse Research RNAi RNAi pathway strain Strains stress conditions suppresse Target genes underlie
[DOI] 10.1371/journal.pgen.1006686 PMC 바로가기 [Article Type] Research Article

Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis

게놈 전반에 걸친 상위성 분석으로 식별된 저항성, 독성 및 핵심 기계 유전자의 상호 작용 네트워크

Research Article

Published on 2017-02-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증,

[키워드] activity Algorithm Analysis Antibiotic resistance applied approach arising Bacteria Bacterial bases Beta-lactam beta-lactam antibiotics candidate cellular change chromosome coding sequence complement contribute Critical data set data sets dataset dihydrofolate Diversity DNA driver ENhance epistasis epistatic interaction epistatic interactions Evolution experimental work functions Genes Genetic variation Genome Genome-wide association studies Genome-wide association study genomic Genomic analysis genomic data highlight human pathogen hypothese hypotheses identify Interaction interactions lack Linkage disequilibrium loci locus non-susceptibility Organisms over parameter Pathogens pbp1a phenotype pneumococcus polymorphism Polymorphisms Protein pseudouridine recent representing reveal RNA sequence sequences significantly statistical statistical model statistically Streptococcus Streptococcus pneumoniae Streptococcus pyogene Streptococcus pyogenes structural biology synthases Systems biology target targets the strongest trimethoprim underlie virulence
[DOI] 10.1371/journal.pgen.1006508 PMC 바로가기 [Article Type] Research Article

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease

유전 변이는 점막 염증 질환에서 T-bet 결합 및 유전자 발현을 변경합니다

Research Article

Published on 2017-02-102022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] Affect alleles Alter alteration Arthritis association autoimmune conditions Autoimmune disease Autoimmune diseases Autoimmunity autoinflammatory disease binding binding site Cancer CD4+ T cell CD4+ T cells celiac disease certainty ChIP ChIP-seq condition contribute Crohn’s disease decreased expression disease disease-associated distal DNA elements environmental factors eQTL examined exons expression expression quantitative trait locus Gene Expression Genetic Genetic polymorphism genetic polymorphisms Genetic variant genetic variants Genetic variation Genome-wide association studies helper cell heterozygous identify IL18RAP immune response in vitro in vivo increased risk individual Infection Inflammatory inflammatory disease Inflammatory diseases Lineage locus majority mechanism modulating molecular mechanism mucosal nucleotide Other polarization polymorphism protective immunity Protein psoriasis Quantitative quantitative trait locus Region regulate Regulatory represse reveal rheumatoid arthritis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs subsequent susceptibility susceptibility to infections T cell T cells T helper cell TBX21 Th1 transcription factor transcription factors transcriptional ulcerative colitis underlie variant
[DOI] 10.1371/journal.pgen.1006587 PMC 바로가기 [Article Type] Research Article

A Multistate Toggle Switch Defines Fungal Cell Fates and Is Regulated by Synergistic Genetic Cues

다중 상태 토글 스위치는 곰팡이 세포의 운명을 정의하고 시너지 유전 신호에 의해 조절됩니다

Research Article

Published on 2016-10-062022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] accompany Analysis antagonistic can be used Candida tropicalis Cell cell differentiation cell fate cell type cell types cellular change chromatin Combination determined by ectopic ectopic expression Epigenetic event exhibit expression Fate Formation fungal fungi Gene Expression Gene expression profiles Genetic genetic analysis genetic regulation growth rates higher eukaryotes hybrid increase induce instances lack less master regulator multicellular organism multicellular organisms occurred opposite pathogen phenotypic Regulation stability stable cell stem cell switch switching synergistic to define transcription factor transcription factors transcriptional transcriptionally underlie unique Wor1 yeast
[DOI] 10.1371/journal.pgen.1006353 PMC 바로가기 [Article Type] Research Article

Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines

Hsp40s는 Hsp104 및 Hsp90 단백질 샤페론 기계의 기능을 지정합니다

Research Article

Published on 2014-10-162022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

Alterations in Nerve-Evoked Bladder Contractions in a Coronavirus-Induced Mouse Model of Multiple Sclerosis

Research Article

Published on 2014-10-132022-10-28
Journal: PLoS ONE [Category] Coronavirus,

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

Caenorhabditis elegans의 소포 수송에 의한 세포 간 프리온 도메인의 확산

Research Article

Published on 2013-03-282022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] aggregate aggregation ALS amyloid Amyotrophic lateral sclerosis animal model appearance asparagine Author autonomous autophagy Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans Cell cellular cellular pathway conformation culture cell cytosolic Degradation developmental delay different disease Diseases domain elegan embryonic Encephalopathy Epigenetic Evidence exhibit expressed expressing expression form Glutamine hallmark hallmarks include infect infectious Lateral Sclerosis lobar lysosomal lysosomal vesicle mechanism misfolded protein misfolded proteins mitochondrial multicellular multicellular organism N-terminus naive cells neurodegenerative neurodegenerative disorders NM organism Parkinson's Disease pathology pathway prion Propagation Protein Proteins real time recent Spread spreading thought tissue tissue culture tissues Toxicity trait transgenic mice transmissible spongiform encephalopathies Transmission Transport underlie Vesicle vesicular widespread yeast
[DOI] 10.1371/journal.pgen.1003351 PMC 바로가기 [Article Type] Research Article