Modelling optimal vaccination strategies against COVID-19 in a context of Gamma variant predominance in BrazilArticle Published on 2022-11-022022-11-16 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] accompanied age AZD1222 Brazil circulating variant Coverage COVID-19 death deaths dose driven by Effectiveness Epidemic estimates evaluate evaluated Evidence Gamma group groups Guidance health system immunization immunization strategy implementation increase in inefficient initial International interval Local modelling Older age outcome populations reached reducing required subsequent Support vaccination Vaccination strategy Vaccine vaccine availability Vaccines variant variants of concern VoC [DOI] 10.1016/j.vaccine.2022.09.082 PMC 바로가기
Hamsters Protected from SARS-CoV-2 Delta Variant Challenge after Two Doses of Adjuvanted SARS-CoV-2 Recombinant Spike Protein (S-2P) and One Dose of Beta S-2PArticle Published on 2022-11-012022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome Beta challenge coronavirus COVID-19 COVID-19 vaccine Delta dose Effectiveness hamster hamster challenge study highest live SARS-CoV-2 Live virus lung MVC-COV1901 neutralization Neutralizing antibody titer Omicron variant pathology prefusion PROTECT pseudovirus recombinant regimen S-2P SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 vaccine spike Spike protein subunit Subunit vaccine suggested vaccination Vaccines variant variant of concern variants variants of concern virus Wuhan [DOI] 10.1093/infdis/jiac153 PMC 바로가기
Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variantsArticle Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] Analysis antibodies antibody Beta breadth complementary conserved CP: Immunology CP: Microbiology Efficacy Hamster model human monoclonal antibodies immune Immune escape in vivo interact monoclonal antibody mutations neutralization neutralize Neutralizing activity omicron Omicron sublineages BA.1., BA.2, BA.2.12.1, and BA.4 overcome potent Protective provide raise reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein Spread the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic antibodies therapeutic efficacy Vaccine variant variants variants of concern [DOI] 10.1016/j.celrep.2022.111528 PMC 바로가기
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] A570D A701V addition Affect affected antibodies antigenicity B.1.1.529 B.1.1.7 B.1.1.7 lineage B.1.351 B.1.617.2 BALB/c mice binding circulating cross-neutralization activity D1118H decrease Del Delta determine DNA vaccine Effects Efficiency elicited humoral immune response immune evasion immunized immunogen in vitro investigated K417N L18F Lineage Mutation NAbs Naturally neutralization Neutralizing Neutralizing antibodies neutralizing antibody NTD omicron opposite overcome P681H Pseudotyped viruses reduced S982A SARS-CoV-2 SARS-CoV-2 variant sera significantly increased single mutation single mutations spike mutation T cell T cell responses T-cell Response T716I tested the RBD Transmissibility unlikely Vaccine vaccine immunogenicity variants of concern viral entry viral infectivity VoC VOCs was determined weakened [DOI] 10.1038/s41423-022-00924-8 PMC 바로가기
SARS-CoV-2 Omicron BA.5: Riding the seventh wave in Central CanadaArticle Published on 2022-11-012022-11-16 Journal: Influenza and Other Respiratory Viruses [Category] SARS, 변종, [키워드] Abstract BA.5 Canada COVID-19 omicron SARS-CoV-2 subvariant variants of concern [DOI] 10.1111/irv.13046 PMC 바로가기
Temporal changes in the accessory protein mutations of SARS-CoV-2 variants and their predicted structural and functional effectsArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] accessory protein accessory proteins Affect amino acid sequence association bioinformatics candidate changes in contributing to correlation COVID-19 determine domains Effect Factor Frequency functional humans identify Infection Mutation mutations occur ORF6 ORF8 predicted Protein PROVEAN Q57H SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequence spike Spread Temporal variant variants of concern was used [DOI] 10.1002/jmv.27964 PMC 바로가기
Immunogenicity of Third-dose BNT162b2 mRNA Vaccine Following Two Doses of ChAdOx1 in Health Care Workers: A Prospective Longitudinal StudyArticle Published on 2022-11-012022-11-16 Journal: Annals of laboratory medicine [Category] SARS, 변종, [키워드] acute respiratory syndrome analyzed anti-S antibody BNT162b2 BNT162b2 mRNA ChAdOx1 collected Concentration coronavirus Coronavirus disease-19 COVID-19 delta variant demonstrated dose doses Effectiveness Efficacy eight healthcare worker help immunogenicity longitudinal NAbs Neutralizing neutralizing antibody occurred omicron outbreak pandemic predicted produced Prospective PROTECT reached regimen risk second dose study period the vaccine Three-dose vaccination. university hospital vaccination vaccination rate variant variants of concern Wuhan-Hu-1 [DOI] 10.3343/alm.2022.42.6.688 PMC 바로가기
Differences in environmental stability among SARS-CoV-2 variants of concern: both omicron BA.1 and BA.2 have higher stabilityArticle Published on 2022-11-012022-11-16 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, [키워드] Beta calculated Characteristics Concentration contributing to Delta difference Disinfection Disinfection effectiveness Effectiveness Efficacy environmental stability evaluate evaluated Ex vivo exhibited Gamma in vitro inactivated Infection median omicron regression analysis risk SARS-CoV-2 SARS-CoV-2 variant Spread stability survival transmissibility of SARS-CoV-2 Transmission variant variants variants of concern virus Virus survival. virus titre VoC VOCs was determined were measured Wuhan Wuhan strain [DOI] 10.1016/j.cmi.2022.05.020 PMC 바로가기
ColdZyme® protects airway epithelia from infection with BA.4/5Article Published on 2022-10-312022-11-16 Journal: Respiratory Research [Category] COVID19(2023년), SARS, 변종, [키워드] Activation administration airway airway epithelia applied BA.4 BA.5 block blocked complement contagious Critical Culture epithelial in vitro data Infection Inflammation inflammatory reaction Intervention intrinsic omicron Pathogenesis prevented Prophylaxis PROTECT respiratory tissue SARS-CoV-2 SARS-CoV-2 transmission significantly subsequent Transmission variants variants of concern Viral transmission virus infection VoC VOCs while [DOI] 10.1186/s12931-022-02223-2 PMC 바로가기
Analysis of anti-SARS-CoV-2 Omicron-neutralizing antibody titers in different vaccinated and unvaccinated convalescent plasma sourcesArticle Published on 2022-10-292022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] anti-SARS-CoV-2 Antibody titer CCP collected convalescent plasma COVID-19 Donor dose effective geometric geometric mean titer Immune escape Immunocompromised implication Infection lesson monoclonal antibodies monoclonal antibody mRNA vaccine neutralization neutralize Neutralizing Neutralizing antibody titer omicron Outpatient pandemic plasma plasma activity provide recipients reduction representing SARS-CoV-2 variant sera subject therapeutic Therapies uninfected vaccinee variant variants of concern [DOI] 10.1038/s41467-022-33864-y PMC 바로가기