Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19SARS-CoV, SARS-CoV-2 및 SARS-CoV-2 전 세계 분리주 사이의 후성유전 조절자 miRNA 패턴 차이로 팬데믹 COVID-19의 서사적 병원성과 독특한 임상적 특징 뒤에 숨겨진 미스터리Genetics Published on 2020-07-102022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] alleviate anomalies Anomaly antiviral miRNAs autophagy binding breathing complications cardiovascular diseases cellular miRNA cellular pathway clinical Comorbidities Complication computational approach Computational approaches country COVID-19 COVID-19 patients death death rates diabetes difference disease effective epigenetic modulator epigenetic regulator experiments Factors functional Gene Expression Host host antiviral miRNA host genes host immunity host miRNA host's miRNAs human cell IFN-I IFN-I signaling immune regulation immune-escape mechanism immune-signaling pathways implication isolate latency lead Microarray miRNA miRNA clusters miRNA-mediated interaction miRNA-microRNA miRNAs mode modulate molecular mechanism Neutralizing normalized over representation analysis Pathogenesis Pathways patients with comorbidity pattern predict predicted profile regulator RNA therapeutics RNA-Seq SARS virus SARS viruses SARS-CoV SARS-CoV and SARS-CoV-2 viral miRNAs SARS-CoV and SARS-CoV-2 viruses SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 miRNAs SARS-CoV-2 pathogenesis SARS-CoV-2 viral SARS-CoV-2 virus SARS-infected human cell microarray signaling pathways Support symptoms of COVID-19 target targets the SARS-CoV-2 Viral viral miRNA viral miRNAs viral pathogenesis viruses [DOI] 10.3389/fgene.2020.00765 PMC 바로가기 [Article Type] Genetics
Role of Autophagy in Lung InflammationImmunology Published on 2020-07-072022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] accompanied activated antigen presenting cell approach Asthma asthmatic autophagic autophagic flux autophagy caused Cell cell type cells cellular cellular homeostasis changes in characterized complicate COVID-19 decrease develop disease dysfunction Effects eukaryotic functions granulocyte human cell Immune cell immunometabolism Impaired implicated implication Inflammasome Inflammation inflammatory disease Lineage lung Lung inflammation lymphoid lymphoid cell lysosome metabolism modulation myeloid cells non-immune Organisms Pathogenesis pathology phenotype Population populations Protein role SARS-CoV-2 shown specificity survival Symptoms tissue remodeling Treatment variety viral pathogenesis worse prognosis [DOI] 10.3389/fimmu.2020.01337 PMC 바로가기 [Article Type] Immunology
Pathogenesis of COVID-19 from the Perspective of the Damage-Response FrameworkMinireview Published on 2020-07-022022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Alter caused clinical manifestation Community coronavirus coronavirus disease COVID COVID-19 COVID-19 disease COVID-19 pathogenesis disease disparate explain flexible framework Host Immune-mediated manifestation mechanism microbial outcome pandemic Pathogenesis pathogenic Population potential therapy provide SARS-CoV-2 susceptibility viral pathogenesis virus [DOI] 10.1128/mBio.01175-20 PMC 바로가기 [Article Type] Minireview
Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral InfectionsReview Published on 2020-06-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] addition anti-vimentin autoantibodies antibody antiviral strategy appear approach autoantigen Autoimmune disease Bacterial Cell cell activation cell surface cell surface vimentin cell types cellular processe cellular receptor complex contribute coronavirus cytoplasmic cytoskeletal Encephalitis Extracellular filament protein functions immune response implication in viral Infection Inflammation Injury Interaction interfere intermediate filaments Migration modulate Occurrence oxidative damage Pathogens pathophysiological pathophysiology Perspective Phosphorylation posttranslational modifications Potential Proinflammatory cytokine Protein receptor required SARS-CoV secreted shown target tissue damage tissue damage and repair vimentin vimentin–pathogen interactions viral pathogenesis viral pathogens virus viruses [DOI] 10.3390/ijms21134675 PMC 바로가기 [Article Type] Review
An evidence-based framework for priority clinical research questions for COVID-19Research Theme 6: COVID-19 Pandemic Published on 2020-06-302022-10-31 Journal: Journal of Global Health [Category] COVID-19, SARS, [키워드] 2019 novel coronavirus addressed aetiology characterisation China clinical Clinical management Clinical practice clinical study conducted coronavirus Coronaviruses COVID-19 COVID19 database deaths Diagnosis diagnostic epidemiological highlight identify implementation Infection prevention information MERS-CoV Middle East office outbreak Pneumonia Prognosis protocol protocols public health recommendation Research Research question respiratory Result SARS-CoV searched susceptibility systematic review viral pathogenesis World Health Organization [DOI] 10.7189/jogh.10-011001 PMC 바로가기 [Article Type] Research Theme 6: COVID-19 Pandemic
SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonistsResearch Article Published on 2020-06-202022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] activities Amino acid antagonist antagonists caused Characteristics contribute Coronavirus disease 2019 COVID-19 deaths demonstrated deubiquitinase Health Immune suppression Infection interferon interferon antagonist intranasal novel SARS-CoV-2 virus nsp13 nsp14 Nsp15 ORF6 outbreak PLPro protease SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence similarity suppress the SARS-CoV-2 unique Vaccine viral pathogenesis Viral proteins [DOI] 10.1080/22221751.2020.1780953 PMC 바로가기 [Article Type] Research Article
Studies of Novel Coronavirus Disease 19 (COVID-19) Pandemic: A Global Analysis of LiteratureArticle Published on 2020-06-082022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis approach Care China comprehensive analysis conducted content analysis contributed coronavirus disease country COVID-19 COVID-19 pandemic COVID-19 transmission database effort European Features finding foci guideline help knowledge latent Dirichlet allocation literature mitigate novel pandemic problem Regression Research response Result Scientometrics Stage surgical text mining The United States Topic Transmission Variation viral pathogenesis was performed was used Web of Science [DOI] 10.3390/ijerph17114095 PMC 바로가기 [Article Type] Article
The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for ComorbiditiesArticle Published on 2020-06-042022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] “cytokine storm” 229E acute respiratory syndrome alteration Betacoronavirus cause cell signalling pathways Comorbidities Consequences coronavirus Coronavirus-2 COVID-19 COVID-19 disease Critical database decrease effective exacerbated FIVE geographical region greater highest highlight host responses Human identify increased mortality Inflammatory response KEGG KEGG pathway KEGG pathway analysis Lung pathology mechanism MERS microRNAs (miRs 8066, 5197, 3611, 3934-3p, 1307-3p, 3691-3p, 1468-5p) miRNA Mutation number of comorbidities OC43 Pandemics pathogenicity pathway Phylogenetic relationship physiological effect prediction reduced reported response responses resulting SARS-CoV-2 SARS-CoV-2 sequence SARS–CoV-2 selected sequence sequence motif Seven Significant significant pathways similarity Symptom the SARS-CoV-2 Therapeutic approach transcriptional transcriptomic alteration viral pathogenesis viral pathogenicity virus viruses whole-genome [DOI] 10.3390/v12060614 PMC 바로가기 [Article Type] Article
Non-Mouse-Adapted H1N1pdm09 Virus as a Model for Influenza ResearchArticle Published on 2020-05-292023-06-07 Journal: Viruses [Category] 신종인플루엔자, [키워드] animal model influenza infection Influenza virus viral pathogenesis viral toxicity [DOI] 10.3390/v12060590 PMC 바로가기 [Article Type] Article
Mathematical modeling of interaction between innate and adaptive immune responses in COVID‐19 and implications for viral pathogenesisResearch Article Published on 2020-05-132022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 치료제, [키워드] adaptive Adaptive immune response Adaptive immunity Analysis antiviral drugs applied cause caused complications coronavirus COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 Disease progression early phase epithelial cell Host immune response Immunity implication Infection Influenza Influenza virus innate immune response Innate immunity Interaction lung mathematical Mortality opposite pandemic Pathogenesis patients potential treatment option SARS‐CoV‐2 virus SARS‐CoV‐2 severity Suppressing target cell‐limited model the timing viral clearance Viral load viral pathogenesis virus viruses [DOI] 10.1002/jmv.25866 PMC 바로가기 [Article Type] Research Article