Specific Detection of SARS-CoV-2 Variants B.1.1.7 (Alpha) and B.1.617.2 (Delta) Using a One-Step Quantitative PCR Assay1단계 정량적 PCR 분석을 사용한 SARS-CoV-2 변이체 B.1.1.7(알파) 및 B.1.617.2(델타)의 특이적 검출Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjust Alpha Alpha (B.1.1.7) analyzed B.1.1.7 B.1.617.2 classification clinical sample clinical samples Community consequence coronavirus Delta Delta (B.1.617.2) demonstrated described detect detection diagnostic diagnostic assay. dominant epidemiological examined global health Health highlight identify IMPROVE Mutation mutations N gene ORF8 gene PCR provide qPCR quantitative PCR reaction Research respond reverse transcription RNA RT-qPCR SARS-CoV-2 SC-2 surveillance sensitivity severe acute respiratory syndrome Coronavirus Specific spike gene target variant variants variants of concern whole-genome sequencing [DOI] 10.1128/spectrum.02176-21 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Variants in Paraguay: Detection and Surveillance with an Economical and Scalable Molecular Protocol파라과이의 SARS-CoV-2 변종: 경제적이고 확장 가능한 분자 프로토콜을 통한 탐지 및 감시Article Published on 2022-04-222022-09-11 Journal: Viruses [Category] Coronavirus, COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Alpha Amplicon B.1.1.7 detect detection develop Genotype IMPROVE K417 Lambda Lineage lineages Mutation Nanopore nanopore sequencing nasopharyngeal sample P.1 P.2 Paraguay positive protocol real-time RT-PCR resources rRT-PCR Sample Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Sequencing SNP spike spike mutation spike mutations subset Surveillance tested the SARS-CoV-2 the Spike variant variant call variant calls variants whole-genome whole-genome sequencing Zeta [DOI] 10.3390/v14050873 PMC 바로가기 [Article Type] Article
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory CompoundsSARS-CoV-2 3CLpro 억제제에 대한 진행 상황: SARS-CoV 3CLpro 펩티드 모방체 및 소분자 항염 화합물에서 영감Review Published on 2022-04-082022-09-11 Journal: Drug design, development and therapy [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3CLpro accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects Antiviral antiviral target caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Health inhibitor inhibitors inspiration life cycle pathophysiological peptidomimetics Progress protease protease inhibitors Protein proteinase SARS-CoV SARS-CoV-2 sequence homology Sequencing severe acute respiratory syndrome Coronavirus similarity small-molecule inhibitors. viral life cycle whole-genome sequencing [DOI] 10.2147/DDDT.S359009 PMC 바로가기 [Article Type] Review
Genome Profiling of SARS-CoV-2 in Indonesia, ASEAN and the Neighbouring East Asian Countries: Features, Challenges and Achievements인도네시아, 아세안 및 주변 동아시아 국가에서 SARS-CoV-2의 게놈 프로파일링: 기능, 도전 및 성과Article Published on 2022-04-082022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] achievement ASEAN Biology biology of SARS-CoV-2 Biotechnology center challenge Clinical research collaboration country COVID-19 COVID-19 pandemic defined delta variant Delta variants East Asian Epidemiology facilitated Frequency Genome genomic Genomic surveillance GISAID highest Indonesia Innovation Interaction Japan Lineage Metadata Mutation N439K Nanopore NICCRAT ONT Open Access outbreak Oxford Phylogenetic analysis predominant Profiling SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 virus Sequencing Singapore spike gene Surveillance team technology training Travel unique university variant variants variants of concern virus virus transmission WGS whole-genome sequencing [DOI] 10.3390/v14040778 PMC 바로가기 [Article Type] Article
Early introduction, dispersal and evolution of Delta SARS-CoV-2 in Southern Brazil, late predominance of AY.99.2 and AY.101 related lineages남부 브라질에서 Delta SARS-CoV-2의 조기 도입, 확산 및 진화, AY.99.2 및 AY.101 관련 계통의 늦은 우세Article Published on 2022-04-022022-09-11 Journal: Virus research [Category] COVID19(2023년), SARS, 변종, [키워드] America Americas Analysis AY.101 AY.99.2 B.1.617.2 Brazil concern consolidation COVID-19 Delta delta variant dispersal Evolution feature FIVE Gamma genomic Lineage majority Mutation mutational rate pandemic performed Performing phylodynamic Phylogenetic Phylogenetic tree presenting provided replaced replacing reported responsible Rio Grande SARS-CoV-2 sequence sequences Southern Brazil. state Substitution Surveillance variant variants VoC whole-genome sequencing widespread [DOI] 10.1016/j.virusres.2022.198702 PMC 바로가기 [Article Type] Article
Genomic evidence of SARS-CoV-2 reinfection in the Republic of Korea대한민국에서 SARS-CoV-2 재감염의 게놈 증거Article Published on 2022-04-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Asymptomatic continuous monitoring coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic epidemiological Epsilon Epsilon variant Evidence genetic differences genome sequence Genome sequences identify increasingly Infection initial Mild symptom mild symptoms pandemic Patient performed Reinfection reported Republic of Korea SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Sequencing severe acute respiratory syndrome Coronavirus Stage Swab swabs variant Viral RNA viral RNA extracted whole genome Whole genome sequencing whole-genome sequencing [DOI] 10.1002/jmv.27499 PMC 바로가기 [Article Type] Article
Rapid and sensitive detection of SARS-CoV-2 variants in nasopharyngeal swabs and wastewaters비인두 면봉 및 폐수에서 SARS-CoV-2 변이체의 신속하고 민감한 검출Article Published on 2022-04-012022-09-11 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Affect allelic appearance carried characterized clade clades containment strategies detect diffusion disease severity Effectiveness Evolution functional genomic genotypes Genotyping assay help host immunity house Interaction limit mutations Nasopharyngeal swab nasopharyngeal swabs new SARS-CoV-2 NGS poor quality Rapid SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus Spread tested urgency variant Variation variations viral genome virus Virus evolution VOCs wastewater whole-genome sequencing [DOI] 10.1016/j.diagmicrobio.2021.115632 PMC 바로가기 [Article Type] Article
Evidence of SARS-CoV-2 symptomatic reinfection in four healthcare professionals from the same hospital despite the presence of antibodies항체가 있음에도 불구하고 같은 병원의 의료 전문가 4명에서 SARS-CoV-2 증상 재감염의 증거Article Published on 2022-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Chain Reaction collected conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic disease event Evidence evidence of exposure to Follow-up Habib Bourguiba HCWs Healthcare professional healthcare worker Healthcare workers hospital IgG IgM Immune status individual Infection initial isolate natural infection occurred Patient patients polymerase chain reaction positive presence of antibody protective immunity public health Quantitative raising ranged Reinfection reported respiratory respiratory specimen reverse transcriptase reverse transcriptase-polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 variant serology specimen Symptom symptomatic the patient total Ig university vaccination variants Viral viral genome viral genomes Viral RNA viral RNAs viral sample viral samples viral sequence viral sequences were used whole-genome sequencing [DOI] 10.1016/j.ijid.2022.01.006 PMC 바로가기 [Article Type] Article
Infection prevention and control insights from a decade of pathogen whole-genome sequencing10년 간의 병원체 전체 게놈 시퀀싱을 통한 감염 예방 및 제어 통찰력Review Published on 2022-04-012022-09-11 Journal: The Journal of hospital infection [Category] COVID19(2023년), SARS, 변종, [키워드] antimicrobial resistance arising Attention Benchmarking Candida Clostridioide Clostridioides Community COVID-19 pandemic Culture Diagnosis Diseases Epidemiology explain greater group healthcare worker Healthcare workers heterogeneity hospital identify implication individual Infection infection control Infection prevention infections Infectious diseases involved metagenomic sequencing Mycobacterium outbreak pathogen Pathogens Patient Prevent Prevention and control provided SARS-CoV-2 sequencing Sequencing Staphylococcus aureus subtype Surveillance thought Transmission transmission route Transmission routes variant variants whole-genome sequencing [DOI] 10.1016/j.jhin.2022.01.024 PMC 바로가기 [Article Type] Review
Elevated plasma levels of CXCL16 in severe COVID-19 patients중증 COVID-19 환자에서 CXCL16의 혈장 수준 상승Clinical Trial Published on 2022-04-012022-09-11 Journal: Cytokine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] association baseline benefit Cell cellular chemotaxis clinical trial Cohort collected controls COVID-19 CXCL16 CXCR6 defined determine disease elevated Genome-wide association studies homing hospitalized COVID-19 patient hospitalized patient hospitalized patients Immunopathogenesis Injury interact Ligand locus lung Lung infection Lungs motif P-value Pathogenesis Patient plasma plasma concentration plasma concentrations Plasma levels reported risk severe COVID-19 severe COVID-19 patient severity of COVID-19 Support susceptibility T cell T cells variant were assessed WHO Whole genome sequencing whole-genome sequencing [DOI] 10.1016/j.cyto.2022.155810 PMC 바로가기 [Article Type] Clinical Trial