Zn 2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell CultureResearch Article Published on 2010-11-042022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activity Antiviral arteritis arterivirus Author binding block both viruses catalyzed Cell Cell culture Combination complex Complexes Concentration described divalent cation E. coli eliminating enzyme equine found function host proteins impair in vitro activity in vitro study include Increased Increasing Infected Influenza virus inhibit inhibited inhibitory effect Ionophore molecular nidovirus nidovirus Nsp12 Nsp9 Pathogens plasma Poliovirus polymerases polyprotein polyproteins Proteolytic processing protocol provide purified RdRP RdRps reduced related Replication replication complex replicative Research reversed RNA RNA synthesis RNA viruses RNA-dependent RNA polymerase RTC SARS-coronavirus SARS-CoV target Transcription Transport variety Viral RNA virus virus Zinc Zn [DOI] 10.1371/journal.ppat.1001176 PMC 바로가기 [Article Type] Research Article
The expression and antigenicity of a truncated spike-nucleocapsid fusion protein of severe acute respiratory syndrome-associated coronavirusResearch Article Published on 2008-11-282022-10-28 Journal: BMC Microbiology [Category] Coronavirus, [키워드] absence analyzed antibody Antigen antigenicity antiviral efficacy assays BALB/c mice cloned coronavirus cross-reactivity determined diagnostic effective drugs effective vaccine ELISA Escherichia coli evaluate expressed expression expression vector fluorescent fusion protein HCoV 229E human coronavirus human coronaviruses humoral IFA immunization immunized mice immunoblot induce inhibit injected injection intranasally Laboratory test management mice National neutralization nucleocapsid OC43 Protein Quantitative reactivity Result RT-PCR SARS patient SARS virus Sensitivity and specificity sera T cell proliferation T-cell analysis T-cell Response vaccine candidate Viral load virus replication was performed [DOI] 10.1186/1471-2180-8-207 PMC 바로가기 [Article Type] Research Article
Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and SArticle Published on 2007-03-012022-10-06 Journal: Antiviral Research [Category] 진단, [키워드] accessory proteins acute respiratory syndrome aspecific assay coronavirus demonstrated Efficiency eight expressing expression full-length Genome genomic indirect immunofluorescence infected cell inhibit inhibition knockdown mRNA not affected nucleocapsid protein nucleotide Open reading frame ORF ORFs progeny Protein Proteins reduction in Replication RNA SARS CoV SARS-CoV sgRNA sgRNAs siRNA siRNAs specificity tested translated Vero E6 cell viral infection Viral protein virus were infected without affecting [DOI] 10.1016/j.antiviral.2006.10.008 PMC 바로가기 [Article Type] Article
Interferon-β 1a and SARS Coronavirus ReplicationResearch Published on 2004-02-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome antiviral drugs caused coronavirus Critical death effective effort identify in vitro inhibit Intensive interferon Novel coronavirus outbreak public health Replication SARS SARS Coronavirus therapy Treatment [DOI] 10.3201/eid1002.030482 PMC 바로가기 [Article Type] Research