Neutralizing antibodies – Page 130 – Communicable Diseases Research

Androgen sensitivity gateway to COVID-19 disease severity

COVID-19 질병 중증도에 대한 안드로겐 민감성 관문

Article

Published on 2020-11-012022-09-11
Journal: Drug development research [Category] SARS, 변종, 유전자 메커니즘,

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

SARS-CoV-2 스파이크 단백질 변이체에 의한 중화 항체로부터의 탈출

Research Article

Published on 2020-10-282022-09-10
Journal: eLife [Category] MERS, SARS, 변종, 진단,

[키워드] activate addressed Administered Analysis anti-SARS-CoV-2 antibodies antibody antibody combination antibody-based therapies antibody-based therapy Blood blood plasma cause Cell cells changed chimeric circulating Combination convalescent plasma coronavirus COVID-19 COVID19 creating effective vaccine Effective vaccines Effectiveness effort elicited eLife Epitopes escape evade Frequency functional Genome Health HIV host cells Human human cells human population human populations immune immune response immune system in some individual infect Infection Influenza kill Laboratory limit low frequencies maintain monoclonal antibodies monoclonal antibody mutant mutant virus mutate mutated Mutation N-terminal domain natural infection neutralize Neutralizing antibodies neutralizing antibody neutralizing epitopes New coronavirus Patient Population populations Prevent produced Prophylactic Proteins question RBD Receptor-binding domain Recovered COVID-19 patients reporter Research SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 spike protein SARS-CoV-2 variant selected Sequencing Spike protein Spike proteins Structure structures target the antibody the disease the receptor-binding domain the SARS-CoV-2 the spike protein the strongest therapeutic Therapies treated Trigger vaccination Vaccine Vaccines variant Viral protein Viral proteins virus virus mutation virus particle virus particles viruses VSV were infected
[DOI] 10.7554/eLife.61312 PMC 바로가기 [Article Type] Research Article

Overcoming Symmetry Mismatch in Vaccine Nanoassembly through Spontaneous Amidation

Research Article

Published on 2020-10-272022-10-28
Journal: Angewandte Chemie (International ed. in English) [Category] COVID-19,

Antibody Binding to SARS-CoV-2 S Glycoprotein Correlates with but Does Not Predict Neutralization

Communication

Published on 2020-10-262022-10-28
Journal: Viruses [Category] COVID-19, MERS, SARS,

Serum-IgG responses to SARS-CoV-2 after mild and severe COVID-19 infection and analysis of IgG non-responders

경증 및 중증 COVID-19 감염 후 SARS-CoV-2에 대한 혈청-IgG 반응 및 IgG 무반응자 분석

Research Article

Published on 2020-10-212022-08-13
Journal: PLoS ONE [Category] COVID-19, Medicine and Health Sciences, MERS, SARS,

[키워드] Abbott Abbott Laboratories Abbott Laboratory age Analysis antibody Antibody titers Architect clinically Cohort cohort of patient Concentration COVID-19 COVID-19 patient detectable develop female Follow-up house iFlash IgG IgG antibodies IgG antibody IgG level IgG responses Immunity imperative Interpretation knowledge median Mild Mild symptom mild symptoms Neutralizing antibodies non-responder Nucleocapsid proteins Patient preserved quantified Receptor binding remained response Result SARS-CoV-2 SARS-CoV-2-specific IgG Seroconversion seroconvert seroconverted Serological assay seronegative serum severe COVID-19 Severe COVID-19 Infection severe symptom severe symptoms severity of symptoms significantly shorter specific IgG antibodies spike and nucleocapsid proteins spike-protein symptom onset time virus-neutralizing antibodies virus-neutralizing antibody
[DOI] 10.1371/journal.pone.0241104 PMC 바로가기 [Article Type] Research Article

Anti-spike, Anti-nucleocapsid and Neutralizing Antibodies in SARS-CoV-2 Inpatients and Asymptomatic Individuals

Microbiology

Published on 2020-10-192022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] anti-N antibody anti-RBD anti-S2 anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody asymptomatic individual asymptomatic patients Convalescent plasma therapy COVID-19 declined detectable evaluate help immune response in-house ELISAs individual induce infected patients Inpatient majority Neutralizing antibodies neutralizing antibody Neutralizing antibody response nucleocapsid Particle post-symptom onset predict pseudotyped RBD reached Reinfection retroviral SARS-CoV-2 Seroconversion serological Serological assay seropositive shown specific antibody spike subunits the SARS-CoV-2 undetectable Vaccine Vaccines
[DOI] 10.3389/fmicb.2020.584251 PMC 바로가기 [Article Type] Microbiology

Rapid in vitro assays for screening neutralizing antibodies and antivirals against SARS-CoV-2

Article

Published on 2020-10-142022-11-01
Journal: Journal of virological methods [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome antibody Antiviral antiviral activity antivirals can be used China complex Compound coronavirus coronavirus disease Coronavirus-2 CoV COVID-19 COVID-19 disease death described drug effective food global pandemic Health human infection humans identify Impact In vitro assay inhibitors mAb mAbs microneutralization MNA monoclonal antibodies monoclonal antibody neutralization neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Novel coronavirus peroxidase Plaque reduction microneutralization assay polyclonal antibodies Prophylactic Rapid reduce reduction reported responsible SARS-CoV SARS-CoV-2 SARS-COV-2 infection Scientific community staining Standardization Therapeutic treatment United State Vaccine while Wuhan
[DOI] 10.1016/j.jviromet.2020.113995 PMC 바로가기 [Article Type] Article

A Review of the Progress and Challenges of Developing a Vaccine for COVID-19

COVID-19 백신 개발의 진행 상황 및 과제 검토

Review

Published on 2020-10-142022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 신약개발, 진단, 치료기술,

[키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affecting anticipated ARDS AstraZeneca Asymptomatic AZD1222 cause challenge China claimed clinical trial clinical trials CoronaVac coronavirus Coverage COVID-19 COVID-19 pandemic death develop Developing DNA vaccine effective Efficacy effort eight focus global pandemic hygiene immunogenic immunological implication inactivated virus particle vaccine individual Infectious disease International life measure Moderna mRNA-1273 Neutralizing antibodies non-replication viral vector vaccine Novel coronavirus Phase 1 Pneumonia potential limitation potential limitations present Progress PROTECT referred to Repurposed drugs required respiratory respiratory distress Respiratory distress syndrome review RNA vaccine SARS-CoV-2 SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus Sinovac social distancing Spread Stage Symptom syndrome Vaccine vaccine candidate vaccine candidates Vaccine development vaccine platform Vaccines vulnerable population Wuhan
[DOI] 10.3389/fimmu.2020.585354 PMC 바로가기 [Article Type] Review

Kinetics of Nucleo- and Spike Protein-Specific Immunoglobulin G and of Virus-Neutralizing Antibodies after SARS-CoV-2 Infection

Article

Published on 2020-10-132022-10-29
Journal: Microorganisms [Category] COVID-19,

In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

Research Article

Published on 2020-10-092022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, Fulltext, SARS,