populations – Page 130 – Communicable Diseases Research

Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations

세 아프리카 인구에서 심각한 말라리아의 대치 기반 메타 분석

Research Article

Published on 2013-05-232022-09-12
Journal: PLoS Genetics
[Category] Communicable Disease,

Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families

Plasmodium falciparum의 유사분열 진화는 안정적인 핵심 게놈을 보여주지만 항원 가족에서 재조합을 보여줍니다

Research Article

Published on 2013-02-072022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] absence allele amplification Analysis anti-malarial drug Anti-malarial drugs antigenic variation atovaquone Author average base pair change chromosomal crossover chromosomal crossovers chromosome chromosome 1 clone clones Combination Complete core core genome cytochrome b death Deletion determined develop different disease drug drug pressure drug resistance drug target effort evade event Evolution family FIVE found Frequency Gene gene families genetic change Genetic changes Genome genomic alteration global health Haplotype Health help Host Host immune response host immune responses human host immune evasion immune resistance immune response immune responses IMPROVE in vitro increase individual level Infectious disease initiated involved malaria malaria parasites microarray technique mitosis mitotic mitotic recombination mrp1 Multidrug resistance multigene families multigene family Mutation mutation rate Mutation rates natural infection nucleotide occur P. falciparum parasite parasites Plasmodium Plasmodium falciparum plasticity populations presence or absence Protein Recombination recombination event Region responsible sequence variability show Single nucleotide variant single nucleotide variants STABLE strain Structural variant structural variants subtelomeric region subtelomeric regions var gene family whole-genome microarray whole-genome sequencing
[DOI] 10.1371/journal.pgen.1003293 PMC 바로가기 [Article Type] Research Article

Mutational Spectrum Drives the Rise of Mutator Bacteria

돌연변이 스펙트럼은 돌연변이 박테리아의 증가를 주도합니다

Research Article

Published on 2013-01-102022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

Genome-Wide Association Studies Reveal a Simple Genetic Basis of Resistance to Naturally Coevolving Viruses in Drosophila melanogaster

Genome-Wide Association Studies는 Drosophila melanogaster에서 자연적으로 공진화하는 바이러스에 대한 저항성의 단순한 유전적 기초를 보여줍니다

Research Article

Published on 2012-11-152022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major alleles Antiviral appear Author Basis caused DCV disease disease susceptibility Drosophila Drosophila melanogaster explain expression found Frequency fruit Genes Genetic genetic component Genetic variant genetic variants Genetic variation Genome-wide association studies Genome-wide association study GWAS heritability identify inbred line inbred lines individual infect Infected Infectious disease insect Insects knocking down Mutation natural selection Naturally polymorphism Polymorphisms populations resistance resistance to infection RNAi shown simple susceptibility susceptible understanding variant Variation Viral viral infection virus virus resistance viruses
[DOI] 10.1371/journal.pgen.1003057 PMC 바로가기 [Article Type] Research Article

Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility

보체 인자 H 및 인자 H 관련 유전자의 유전적 변이체와 전신성 홍반성 루푸스 감수성의 연관성

Research Article

Published on 2011-05-262022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation addition African American African Americans allelic American amplification Analysis Asian Asians association Author Autoimmune disease Case-control causal variant CFH CFHR1 CFHR3 CFHR4 CFHR5 chromosome chromosome 1q32 complement Complement activation complex contribute datasets Deletion described detected disease-associated downstream dysregulated Ethnic groups European Evidence exonic exonic SNPs Factor FIVE Gene genes encoding Genetic variant genetic variants genotypic haplotype analysis heterozygous higher risk homozygous human disease human diseases impair intron Intronic locus Lupus lupus erythematosus multiplex Pathogenesis populations Previous studies previous study probe Protein provide provided Regulation Significant SLE SNP SNPs subject suggested susceptibility systemic systemic lupus erythematosus tested variant variants
[DOI] 10.1371/journal.pgen.1002079 PMC 바로가기 [Article Type] Research Article

Genetics and Pathogenesis of Feline Infectious Peritonitis Virus

Research

Published on 2009-09-012022-10-31
Journal: Emerging Infectious Diseases
[Category] Coronavirus,

Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection

Research Article

Published on 2009-05-012022-10-28
Journal: BMC Infectious Diseases
[Category] Coronavirus,

Field-Caught Permethrin-Resistant Anopheles gambiae Overexpress CYP6P3, a P450 That Metabolises Pyrethroids

현장에서 포착된 퍼메트린 내성 Anopheles gambiae CYP6P3, 피레스로이드를 대사하는 P450 과발현

Research Article

Published on 2008-11-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] A. gambiae adaptive adaptive mechanism adaptive mechanisms Alpha alpha-cyano Anopheles gambiae anopheline mosquitoes Author bioassays compounds Critical CYP6P3 cytochrome P450 detect disease spread Efficacy ENCODE enzyme Enzymes Evolution facilitate found Frequency Gene Gene Expression Genetic Health health problem identify individual insect insecticide insecticides Insects involved lead low frequencies malaria malaria vector malaria vector control mechanism Messenger RNA Metabolic resistance metabolise Molecular assay molecular mechanism molecular mechanisms MONITOR natural selection overexpressed P450 pesticide pesticides phenotyped populations public health pyrethroid Pyrethroids receiving recessive allele reducing resistance significantly sub-Saharan Africa Survivors sustainability trait transcript level translated Transmission undergo
[DOI] 10.1371/journal.pgen.1000286 PMC 바로가기 [Article Type] Research Article

Vaccine Efficacy in Senescent Mice Challenged with Recombinant SARS-CoV Bearing Epidemic and Zoonotic Spike Variants

Research Article

Published on 2006-12-262022-10-29
Journal: PLoS Medicine
[Category] Coronavirus, Fulltext, 조류인플루엔자,

[키워드] 2003 acute respiratory syndrome addition Administered Antisera bat bats Bearing candidate vaccine caused Cell cellular immune responses center characterized chimeric China Cluster coding Complete Consequences Control coronavirus cross death death rate death rates develop died different disease effective Efficacy eight elicit Epidemic etiological agent examined expressing finding flu found future infection Gene genetic material genetics glycoprotein group Guidance Heterologous heterologous challenge homologous homologous or heterologous homologous strain challenge Human human airway epithelial humans identify immune response immunized immunopathology infect Infected Infection information injected lung mice much higher neutralization nucleocapsid Older Outbreaks Particle pathological change pathology peaked phylogenetic analyses populations PROTECT Protein Proteins provide provided recombinant related virus related viruses replicated researcher reservoirs resource robust rodents S glycoprotein SARS Coronavirus SARS infection SARS virus SARS-CoV SARS-CoV N SARS-CoV S SARS-CoV S protein SARS-CoV vaccine SARS-CoV virus senescent severe severe pneumonia spike spike glycoprotein Spread strain Strains tested the disease the vaccine thought vaccination Vaccine vaccine candidate Vaccine design Vaccine development Vaccines variant Venezuelan equine encephalitis virus virus virus strain was used Web West Nile Virus World Health Organization zoonosis zoonotic
[DOI] 10.1371/journal.pmed.0030525 PMC 바로가기 [Article Type] Research Article