Human Monoclonal Antibody Derived from Transchromosomic Cattle Neutralizes Multiple H1 Clades of Influenza A Virus by Recognizing a Novel Conformational Epitope in the Hemagglutinin Head DomainArticle Published on 2020-08-262023-06-14 Journal: Journal of Virology [Category] Fulltext, 신종인플루엔자, [키워드] epitope Influenza monoclonal antibodies Neutralizing antibodies [DOI] 10.1128/JVI.00945-20 PMC 바로가기
Computational Alanine Scanning and Structural Analysis of the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 ComplexArticle Published on 2020-08-242022-10-27 Journal: ACS Nano [Category] COVID-19, [키워드] ACE2 ACE2 receptor acute respiratory syndrome allelic variant angiotensin-converting enzyme 2 Blood cellular receptor computational alanine-scanning mutagenesis contributing to coronavirus coronavirus disease COVID-19 COVID-19 patient Critical D38 determinant domain effective etiological agent free energy of binding global pandemic global public health glycoprotein homeostasis Host in silico inhibitor Interaction K31 K353 molecular mechanics/Poisson−Boltzmann surface area molecular molecular dynamics Neutralizing antibodies New coronavirus pathogen provide Q498 Quantitative R403 Receptor-binding domain residue S-protein SARS-CoV-2 SARS-CoV-2 host cell SARS-CoV-2 spike protein scanning spike stability structure-based design T500 the binding affinity the receptor-binding domain the SARS-CoV-2 transmembrane spike Vaccines Vascular Viral protein Volume [DOI] 10.1021/acsnano.0c04674 PMC 바로가기 [Article Type] Article
Computational Alanine Scanning and Structural Analysis of the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 ComplexArticle Published on 2020-08-242022-10-27 Journal: ACS Nano [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome allelic variant angiotensin-converting enzyme 2 Blood cellular receptor computational alanine-scanning mutagenesis contributing to coronavirus coronavirus disease COVID-19 COVID-19 patient Critical D38 determinant domain effective etiological agent free energy of binding global pandemic global public health glycoprotein homeostasis Host in silico inhibitor Interaction K31 K353 molecular mechanics/Poisson−Boltzmann surface area molecular molecular dynamics Neutralizing antibodies New coronavirus pathogen provide Q498 Quantitative R403 Receptor-binding domain residue S-protein SARS-CoV-2 SARS-CoV-2 host cell SARS-CoV-2 spike protein scanning spike stability structure-based design T500 the binding affinity the receptor-binding domain the SARS-CoV-2 transmembrane spike Vaccines Vascular Viral protein Volume [DOI] 10.1021/acsnano.0c04674 PMC 바로가기 [Article Type] Article
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal modelResearch Article Published on 2020-08-212022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 binding site acute respiratory syndrome angiotensin-converting enzyme 2 animal model antibodies antibody binding Cohort convalescent coronavirus coronavirus disease countermeasure COVID-19 develop disease donors enrolled epitope facilitate hamster hamsters Health High-dose host cell indicated lung viral titer monoclonal antibody MOST NAb Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody overlap Participants passive transfer Prevent produced Prophylaxis proportion Protective Protein provide provided RBD RBD-binding antibody receptor Receptor binding domain Region responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody Science selected survivor tested Therapies therapy transfer treat treated Vaccine design viral spike protein [DOI] 10.1126/science.abc7520 PMC 바로가기 [Article Type] Research Article
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktailReport Published on 2020-08-212022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antibodies antibody antibody cocktail antibody resistance antibody treatment approach binding characterized convalescent convalescent patient coronavirus criteria decrease Diseases effective effort escape mutant expresse generate host cells Human humanized mice neutralization Neutralizing antibodies panel of antibody Prevent pseudovirus Receptor binding domain recovered patients SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 spike protein Science selected selective Spike mutant Spike protein spike variants survivor the RBD the spike protein therapeutic three-dimensional structure Treatment viral spike virus virus mutation [DOI] 10.1126/science.abd0827 PMC 바로가기 [Article Type] Report
Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack RateVirology Published on 2020-08-212022-10-30 Journal: Journal of Clinical Microbiology [Category] COVID-19, MERS, SARS, [키워드] animal model antibody assays attack attack rate boat correlates COVID-19 cycle threshold Evidence facilitated Fisher’s exact test Fishery Fishing Follow-up follow-up period Human humans immunological individual individuals Infection initial median Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer outbreak performed protection protective immunity Rate Reinfection reverse transcription-PCR RT-PCR SARS-CoV-2 Sequencing seroconverted serological seropositive significantly suggested Symptom tested Vaccine vessel viral clade viral genome viral infection viral outbreak yielding [DOI] 10.1128/JCM.02107-20 PMC 바로가기 [Article Type] Virology
A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2Research Article Published on 2020-08-072022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition antibody bind binding characterized complex convalescent COVID-19 patients convalescent patient coronavirus COVID-19 defined Developing distribution epitope Epitopes exhibit host cell Local mAb mAbs membrane fusion Microscopy monoclonal antibody monomer N-terminal domain neutralization potency neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody NTD Protein protein complex pseudotyped SARS-CoV-2 RBD RBD-targeting antibody Receptor binding domain S2 domain SARS-CoV-2 Science spike the RBD the S protein the Spike the spike protein therapeutic trimeric virus [DOI] 10.1126/science.abc6952 PMC 바로가기 [Article Type] Research Article
Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2Review Published on 2020-07-312023-07-01 Journal: Trends in pharmacological sciences [Category] SARS, [키워드] Antibody-dependent enhancement COVID-19 drug resistance Neutralizing antibodies SARS-CoV-2 viral escape [DOI] 10.1016/j.tips.2020.07.004 PMC 바로가기 [Article Type] Review
Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in MiceArticle Published on 2020-07-302023-06-18 Journal: Cell Host & Microbe [Category] Fulltext, SARS, [키워드] correlates COVID-19 Humoral immunity Immunity Neutralizing antibodies SARS-CoV-2 Vaccine vesicular stomatitis virus [DOI] 10.1016/j.chom.2020.07.018 PMC 바로가기
SARS-CoV-2 specific serological pattern in healthcare workers of an Italian COVID-19 forefront hospitalResearch Article Published on 2020-07-292022-10-28 Journal: BMC Pulmonary Medicine [Category] COVID-19, Fulltext, [키워드] 95% CI adopted approved Area caused Cohort Combined Committee COVID-19 COVID-19 patient COVID-19 patients disease HCW HCWs healthcare worker highest hospital IG IgG and IgM IgM IgM and IgG Immunopathogenesis individual Infection Infectious disease Italian Italy lateral flow immunoassay male males median age Neutralizing antibodies New Novel coronavirus point-of-care Prevalence Rapid recruited Result risk of infection SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgM serological Seroprevalence Test [DOI] 10.1186/s12890-020-01237-0 PMC 바로가기 [Article Type] Research Article