susceptibility – Page 133 – Communicable Diseases Research

Susceptibility of tree shrew to SARS-CoV-2 infection

Article

Published on 2020-09-292022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

Structural and functional modelling of SARS-CoV-2 entry in animal models

Article

Published on 2020-09-282022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 receptor affected Analysis animal model animal models approach binding binding mode complex Contact country COVID-19 disease effective expressing facilitate ferret functional glycoprotein hACE2 Host human ACE2 indicate influence inhibitory antibody Interaction lack molecular docking Molecular modelling Novel coronavirus outbreak protease Protein Research responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 entry sequence variability small molecule specificity spike spread to susceptibility the SARS-CoV-2 the Spike TMPRSS2 transgenic Transgenic mouse viral entry viral infection Viral proteins
[DOI] 10.1038/s41598-020-72528-z PMC 바로가기 [Article Type] Article

S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 Subunit

Research Article

Published on 2020-09-252022-10-29
Journal: mBio [Category] COVID-19, SARS,

[키워드] accompanied acute respiratory syndrome Analysis analyzed anti-N IgG anti-S2 antibody antibody production asked B cell B cell response circulating conserved convalescent coronavirus coronavirus disease correlated strongly COVID-19 cross-reactive disease ENhance frequencies generate healthy donor Human human coronavirus OC43 IgG IgG antibodies IgG level IgG titer immune memory immune protection Immunity individuals Infection MBC memory B cell memory B cells mononuclear cell MOST non-SARS-CoV-2 protein nucleocapsid pandemic PBMCs Peripheral blood Population Postinfection Production Protein provide RBD reactive Receptor binding domain reflect Reinfection S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins sera specificity Spike protein Spread subject subjects susceptibility susceptible the RBD the S protein the SARS-CoV-2 virus Virus-specific IgG
[DOI] 10.1128/mBio.01991-20 PMC 바로가기 [Article Type] Research Article

Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19

Review

Published on 2020-09-252022-10-30
Journal: Molecules [Category] COVID-19,

[키워드] activities Anti-inflammatory antioxidant appear applied Compromised concomitance conditions Coronavirus disease 2019 COVID-19 Critical Diseases Effect effective energy metabolism ENhance Evolution example expected Fighting function Gender generate Glycolysis Health Host host cell Impact in viral increase individual infections Innate immunity MAVS melatonin metabolite Mitochondria mitochondrial Mitochondrial function Mortality outcome oxygen pandemic Pandemics pathogen pathogen’ Pathogens producing Protective reduce reduced required Respiratory disease seasonal flu severity Support susceptibility System targeting Tolerance viral infection viral infections viral infectious diseases virus infection
[DOI] 10.3390/molecules25194410 PMC 바로가기 [Article Type] Review

The Recommended and Excessive Preventive Behaviors during the COVID-19 Pandemic: A Community-Based Online Survey in China

Article

Published on 2020-09-232022-10-30
Journal: International Journal of Environmental Research an [Category] COVID-19, SARS,

Geriatric Population During the COVID-19 Pandemic: Problems, Considerations, Exigencies, and Beyond

Public Health

Published on 2020-09-222022-10-31
Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome age clinical manifestations confirmed case coronavirus coronavirus disease COVID-19 death decrease determine disease disease control disease severity expression Factor Geriatrics hidden immune function Immunity implementation increased mortality Infection Measures Mortality Older older people organ function pandemic pathophysiologic personal health poor health Population prevention preventive measure Probability PROTECT receptor response resulting risk SARS-CoV-2 severe COVID-19 severity susceptibility Symptom treating COVID-19 underlying disease underlying diseases Vaccine design Vaccines Variation
[DOI] 10.3389/fpubh.2020.574198 PMC 바로가기 [Article Type] Public Health

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

Research Paper

Published on 2020-09-212022-11-01
Journal: EBioMedicine [Category] COVID-19, MERS, SARS,

[키워드] ACE2 ACE2 mRNA ACE2 protein Alveolar Type II alveolar type II cells apical surface association caused Cell children ciliated cells cofactor coronavirus correlation COVID-19 COVID-19 pandemic determine disease disease severity evaluated examined expression Factor Factors finding highest Host human respiratory tract immunohistochemistry incidence interactions Lower respiratory tract lung lung parenchyma material mRNA abundance Numerous offer outbreak protein levels question raise receptor receptor ACE2 reduced Region responsible risk factor SARS-CoV-2 SARS-CoV-2 susceptibility SARS-CoV2 severe COVID-19 severe disease Single-cell RNA sequencing subset susceptibility tissue TMPRSS2 Transmission transmitted Viral transmission
[DOI] 10.1016/j.ebiom.2020.102976 PMC 바로가기 [Article Type] Research Paper

COVID-19 susceptibility: potential of ACE2 polymorphisms

Review

Published on 2020-09-212022-11-01
Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19,

[키워드] Abstract ACE ACE2 ACE2 receptor activate acute respiratory syndrome ADAM17 addition Ang II Angiotensin 1-7 Angiotensin-converting enzyme association binding binding mechanism blood pressure cleavage coronavirus coronavirus disease COVID-19 Critical enzyme Ethnic groups Extracellular function functional Genetic variant indicate Infection initiate involved metalloproteinase MONITOR motifs outbreak polymorphism RAS receptor Receptor binding Region Regulation Release S-protein sACE2 SARS Coronavirus SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome (SARS) single-nucleotide Single-nucleotide polymorphism (SNP) SNP SNPs soluble ACE2 susceptibility transmembrane serine protease TTSP TTSPs viral entry
[DOI] 10.1186/s43042-020-00099-9 PMC 바로가기 [Article Type] Review

Immune Modulatory Effects of Vitamin D on Viral Infections

Review

Published on 2020-09-212022-10-31
Journal: Nutrients [Category] COVID-19, SARS,

Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) among Patients at a Movement Disorders Center

Article

Published on 2020-09-182022-10-31
Journal: Geriatrics [Category] COVID-19,