COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in BrazilShort communication Published on 2020-03-012022-10-05 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 진단, [키워드] Accuracy antibody Antigen Brazil characteristic coronavirus Course COVID-19 COVID-19 pandemic detect diagnostic Diagnostic accuracy false negative result Future highlight IgG antibody IgM antibody IgM/IgG initial measure Meta-analysis Molecular assay Odds ratio platform Random-effects models Registered SARS-CoV-2 SARS-CoV-2 IgM searched sensitivity specificity Swab the disease [DOI] 10.1016/j.bjid.2020.04.003 [Article Type] Short communication
Immunogenicity and safety of different dosing schedules of trivalent inactivated influenza vaccine in pregnant women with HIV: a randomised controlled trialHIV에 감염된 임산부에서 3가 비활성화 인플루엔자 백신의 다양한 투여 일정의 면역원성과 안전성: 무작위 대조 시험Article Published on 2020-01-032022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] age All participants analysed Antenatal Antibody Response assigned Birth clinics completion computer-generated Controlled trial dose dosing schedule double-blind eligible ENhance enrolled enrolment estimated gestational age except for Final finding foundation Frequency funding gestational age greater group Group allocation HIV immunogenic immunogenicity Immunogenicity analyses immunogenicity analysis inactivated induce Infant Infants Influenza influenza vaccine Local Melinda Gate Melinda Gates mother Neonates Newborn newborn infants outcome participant pregnant women protective antibodies Protective antibody randomisation list randomised randomised controlled trial Randomly reaction receive recipient recipients recruited regimen Registered Safety Seasonal influenza seroconversion rate seroconversion rates Seven significantly higher single dose Single-dose South Africa Standard-dose strain Strains systemic reactions the vaccine three groups transfer trivalent Vaccine vaccine dose were measured with HIV women [DOI] 10.1016/S2352-3018(19)30322-4 PMC 바로가기 [Article Type] Article
Effect of Surgical Mask on Setup Error in Head and Neck Radiotherapy두경부 방사선 치료에서 수술용 마스크가 설정 오류에 미치는 영향Article Published on 2020-01-012022-09-11 Journal: Technology in cancer research & treatment [Category] SARS, 치료제, [키워드] addition affected automatically beam calculated can not cancer patient Cancer patients Corona COVID-19 detect directions Effect error exhibited group groups head head and neck radiotherapy isocenter location Mask Masks Neck open Patient patients Prevalence Radiation radiation therapy radiation treatment Radiotherapy Registered roll Rotation selected setup setup error significant difference Standard deviation statistically significant suggested surgical surgical mask t -test the mean the patient Treatment Tumor Virus Disease Volume was performed was used were recorded widespread [DOI] 10.1177/1533033820974021 PMC 바로가기 [Article Type] Article
Bubble continuous positive airway pressure for children with high-risk conditions and severe pneumonia in Malawi: an open label, randomised, controlled trial말라위에서 고위험 조건 및 중증 폐렴이 있는 어린이를 위한 버블 연속 기도 양압: 공개 라벨, 무작위, 대조 시험Article Published on 2019-11-012022-09-06 Journal: The Lancet. Respiratory Medicine [Category] Communicable Disease, [키워드] 1:1 95% CI Administered adverse event adverse events African AIDS Analysis Antibiotics assigned Care cause of death children condition Controlled trial country death did not reduce died District eligibility Empowering enrolled event finding Follow-up foundation funding futility HIV infection hospital Hospital mortality hospitalisation hypoxaemia implementation IMPROVE Infection intention-to-treat less Malnutrition Melinda Gate Melinda Gates monitoring board Mortality MOST nares nasal nasal cannula occur occurred open label Open-label outcome oxygen oxygen saturation participant Patient patient population per protocol Pneumonia Pneumothorax positive airway pressure Primary outcome randomised Randomly receiving Registered Relative risk risk Safe screened severe malnutrition severe pneumonia Society survival Suspected Treatment Trial Ventilation was done with HIV [DOI] 10.1016/S2213-2600(19)30243-7 PMC 바로가기 [Article Type] Article
Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis비알코올성 지방간염에서 미리오신의 치료 효과 및 자가포식 조절Research Published on 2019-10-212022-09-06 Journal: Lipids in Health and Disease [Category] B형 간염, Communicable Disease, [키워드] Acox-2 active CHB administration Adults alternate days analyzed animal model autophagy autophagy function autophagy marker autophagy markers ballooning blockade body weight ceramide ceramide signaling Ceramides change CHB chronic hepatitis Chronic Hepatitis B Control Cpt-1α de novo synthesis disease dyslipidemia elevated expression pattern Fabp1 fatty Fatty acid fatty acid metabolism Fatty liver fatty liver disease healthy hepatic autophagy function HepG2 cell HepG2 cells HFD-induced NASH High fat diet incubated Lipid accumulation liver Liver Biopsy liver biopsy-proven patient liver biopsy-proven patients Liver histology liver pathology lobular inflammation mechanisms metabolism myriocin NAFLD NASH NASH patient NASH patients Non-alcoholic fatty liver disease non-NASH patients nonalcoholic fatty liver Nonalcoholic Fatty Liver Disease oral administration Pathogenesis pathogenic Patient PPARα profiles qPCR qPCR analysis randomly divided RATs Registered Registration Regulation Regulatory restored Result reversed screened serum transaminase serum transaminases significantly significantly increased sphingolipid steatohepatitis steatosis subject three groups Treatment were measured [DOI] 10.1186/s12944-019-1118-0 PMC 바로가기 [Article Type] Research
Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trialDNA 또는 NYVAC 벡터(HVTN 096)가 있는 외피 단백질을 포함하는 다가 HIV 백신의 안전성 및 면역원성: 1b상, 이중 맹검, 위약 대조 시험Article Published on 2019-10-072022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] active treatment Administered administration adverse event allergy antibodies antibody Antibody Response Antibody responses antibody-dependent cell-mediated cytotoxicity approach assigned binding binding antibody boost Cell-mediated cytotoxicity Combination component computer-generated Coverage cranial cytotoxicity died DNA dose doses double-blind early administration effective Efficacy enrolled envelope protein epitope finding followed by foundation funding glycoprotein gp120 healthy healthy volunteer healthy volunteers HIV infection HIV vaccine IgG IgG response IgG responses immunogenicity individual Infection Infectious diseases injection Lymphadenopathy marker measure Melinda Gate Melinda Gates motor vehicle Neutralising Antibodies outcome participant Participants Placebo placebo group placebo-controlled placebo-controlled trial Primary outcomes priming product Protein purified random Randomly reactogenicity regimen Registered responses risk Safety screened Serious Adverse Event Serious Adverse Events Switzerland the placebo group the vaccine trauma Treatment treatment group treatment groups Trial trials vaccination vaccination schedule Vaccinations Vaccine vector Volunteer [DOI] 10.1016/S2352-3018(19)30262-0 PMC 바로가기 [Article Type] Article
Adeno-associated virus vectored immunoprophylaxis to prevent HIV in healthy adults: a phase 1 randomised controlled trial건강한 성인에서 HIV를 예방하기 위한 아데노 관련 바이러스 매개 면역 예방: 1상 무작위 대조 시험Article Published on 2019-03-152022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] adeno-associated virus adverse event adverse events AIDS alternative analyses anti-drug antibody antibody assigned cassettes Clinical research Cohort Complete Consent detect development dose dose-escalation double-blind eligibility eligible ELISA expression finding Follow-up foundation funding Future gene delivery Gene Expression generally mild genomes groups healthy HIV HIV antibodies HIV infection immunisation induce initiative Intervention Intramuscular injection Melinda Gate Melinda Gates men moderate muscle biopsy neutralisation neutralisation activity neutralising Neutralising Antibodies neutralising antibody Phase 1 Placebo placebo-controlled Prevent provided public health quadricep quadriceps randomised randomised controlled trial Randomly reactogenicity receive Registered Research resolved RT-PCR screened Serious Adverse Event Serious Adverse Events serotype serum sustained T-cell Response T-cell responses Tolerability Trial United State United States Vaccine virus Volunteer volunteers was done were recorded [DOI] 10.1016/S2352-3018(19)30003-7 PMC 바로가기 [Article Type] Article
Effectiveness of HIIT compared to moderate continuous training in improving vascular parameters in inactive adults비활동 성인의 혈관 매개변수 개선에 있어 중간 정도의 지속적인 훈련과 비교한 HIIT의 효과Research Published on 2019-02-042022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] 95% CI Adults Aerobic exercise Analysis Arterial stiffness baseline both group both groups brachial brachial artery calculated cancers cardiovascular disease Cardiovascular disease prevention changed Colon condition conditions CVD determine Effect Endothelial dysfunction Evidence greater group Health heart rate IMPROVE improvement Improvements inactive increase individuals interval training Life expectancy metabolic syndrome moderate no significant difference non-communicable diseases normalized parameter parameters participant Physical inactivity physically Prevalence proportion pulse Pulse wave pulse wave velocity Randomly receive Registered Result risk Sedentarism significant difference Strong supplementary material syndrome Trial registration Vascular Vascular function were measured [DOI] 10.1186/s12944-019-0981-z PMC 바로가기 [Article Type] Research
Community based distribution of oral HIV self-testing kits in Zambia: a cluster-randomised trial nested in four HPTN 071 (PopART) intervention communities잠비아의 커뮤니티 기반 구강 HIV 자가 테스트 키트 배포: 4개의 HPTN 071(PopPART) 중재 커뮤니티에 중첩된 클러스터 무작위 시험Article Published on 2018-12-212022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 1:1 95% CI Abuse addition adjusted odds ratio Adults AIDS allergy analysed Care care providers choice Clustering Clusters Community defined distribution door driven by drug Drug Abuse eligible Emergency Evidence evidence of female participants finding foundation funding group HIV HIV positive HIV testing Households Impact implementation individual individual level Infectious diseases initiative Interaction Intervention knowledge list Local logistic regression models Melinda Gate Melinda Gates men mental health no evidence of offer offered Older outcome plan President Primary outcome proportion provided Providing randomisation Randomly reached Registered relief remained Sex South Africa Standard of care Trial were measured women zone [DOI] 10.1016/S2352-3018(18)30258-3 PMC 바로가기 [Article Type] Article
Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial저위험 HIV 감염되지 않은 남아프리카 성인을 대상으로 한 아형 C ALVAC-HIV 및 2가 아형 C gp120/MF59 HIV-1 백신: 1/2상 시험Article Published on 2018-06-182022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI added adjuvant advancement African allergy Antigen assigned binding antibody CD4+ T-cell changed circulating clinical Community component computer-generated Critical double-blind trial Efficacy enrolled exceeded Express finding foundation funding glycoprotein gp120 HIV HIV infection HIV vaccine HIV-1 HIV-uninfected IgG IgG response immune response immune responses immunogenicity IMPROVE Infectious disease Infectious diseases Intramuscular injection investigators Melinda Gate Melinda Gates MF59 network NIAID outcome participant per-protocol per-protocol analysis Placebo predicted Primary outcomes Protein provided random randomisation randomised controlled Randomly recipient regimen Registered registry reported Research responders response risk significantly higher South South Africa strain Strains subtype T-cell Response tested the vaccine threshold titre Trial vaccination Vaccine Vaccine development was done [DOI] 10.1016/S2352-3018(18)30071-7 PMC 바로가기 [Article Type] Article