Real-Time Sequence-Validated Loop-Mediated Isothermal Amplification Assays for Detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)Research Article Published on 2015-04-092022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] accelerated acute respiratory illness amplicons amplification Amplification assay amplify applied assays asymmetric cause coronavirus cross-react detect detection diagnostics E gene facilitate Frame genomic infected cell culture Infection infections isothermal amplification loci management MERS-CoV Middle East mortality rate ORF1b gene plaque forming unit point-of-care primer probe reported respiratory Respiratory pathogens respiratory syndrome coronavirus resulting reverse transcription RT-LAMP supernatant upstream [DOI] 10.1371/journal.pone.0123126 PMC 바로가기 [Article Type] Research Article
The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus PathogenesisReview Published on 2012-11-072022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Accessory accessory protein accessory proteins acute respiratory syndrome affected caused cellular China coronavirus country Effect eight ENCODE expression functional Genome homologous homologues human-to-human transmission infected individual infected individuals Infection Isolation knowledge membrane mortality rate Novel coronavirus nucleocapsid Open reading frame open reading frames ORFs predicted Protein Proteins reported Research respiratory Respiratory disease resulting role SARS-coronavirus SARS-CoV severe Spread subsequent unique virus [DOI] 10.3390/v4112902 PMC 바로가기 [Article Type] Review
New Variants of Porcine Epidemic Diarrhea Virus, China, 2011Dispatch Published on 2012-08-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] China determine diarrhea distribution epidemic diarrhea exhibited full-length infection rate mortality rate New outbreak PEDV Phylogeny Porcine epidemic diarrhea virus Prevalence sequenced spike gene Strains variant variant strain virus viruses [DOI] 10.3201/eid1808.120002 PMC 바로가기 [Article Type] Dispatch
Programmed Death (PD)-1-Deficient Mice Are Extremely Sensitive to Murine Hepatitis Virus Strain-3 (MHV-3) InfectionResearch Article Published on 2011-07-072022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] activate anti-IFN-γ anti-TNF-α Author blockade cascades CD4 CD8 cells characteristic co-expressed Coagulation Combination Control damaged demonstrated described determined exhibited expression Fgl2 FH fibrinogen Fluorescence fulminant viral hepatitis functional hepatocellular IFN-γ immunopathological immunopathological damage Immunotherapy in vivo Infection inhibitory receptor initiate injection investigated led to limit liver Liver damage Lymph node lymph nodes mAb Macrophage maintain mechanism mice Mortality mortality rate mRNA multiple organs murine hepatitis virus Necrosis NK cell occurred organ Pathogenesis peripheral tolerance produced promote Protein Quantitative reduced related RT-PCR sensitive Signaling significantly higher spleen T cells tissue tissue damage tissue lesion tissue lesions TNF-α Transcription was determined wild type wild-type [DOI] 10.1371/journal.ppat.1001347 PMC 바로가기 [Article Type] Research Article
Age as Risk Factor for Death from Pandemic (H1N1) 2009, ChileDispatch Published on 2011-07-012023-06-08 Journal: Emerging Infectious Diseases [Category] Fulltext, 신종인플루엔자, [키워드] age Chile dispatch elderly persons Influenza mortality rate Pandemic (H1N1) 2009 Risk factors viruses [DOI] 10.3201/eid1707.101398 PMC 바로가기 [Article Type] Dispatch
Molecular signature of clinical severity in recovering patients with severe acute respiratory syndrome coronavirus (SARS-CoV)Research Article Published on 2005-09-212022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] 2003 acute respiratory syndrome approach Asia biological systems Blood caused change changes in Clinical severity Clustering Control controls coronavirus correlated disease distress Epidemic expression profile Gene Gene Expression Genes Host human disease immunopathological damage Innate immunity International involved mortality rate Novel coronavirus pathophysiology Patient Peripheral blood Pulmonary infection recovering patient regulated reported Result SARS patient SARS patients SARS-CoV several gene severe severity significantly Spread upregulated while World Health Organization [DOI] 10.1186/1471-2164-6-132 PMC 바로가기 [Article Type] Research Article