Viral and Antibody Kinetics of COVID-19 Patients with Different Disease Severities in Acute and Convalescent Phases: A 6-Month Follow-Up Study급성 및 회복기의 다양한 질병 중증도를 가진 COVID-19 환자의 바이러스 및 항체 동력학: 6개월 추적 연구Article Published on 2020-12-012022-09-11 Journal: Virologica Sinica [Category] MERS, SARS, 진단, 치료법, [키워드] acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response asymptomatic individual Asymptomatic individuals caused China Clinical features close contact Cohort coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient Cycle threshold value Delayed disappearance disease severity Economy Health IgG IgM IgM antibodies IgM antibody Infection Kinetics median Mild Most patients nucleocapsid protein occurred onset of symptoms Patient patients with SARS-CoV-2 Protein reduction in respiratory RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid Seroconversion seropositive serum antibody serum antibody response severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe disease Spread symptomatic cases Symptomatic patients symptoms onset the antibody the vaccine These data titre Viral Viral load Viral RNA Viral RNA shedding viral shedding [DOI] 10.1007/s12250-020-00329-9 PMC 바로가기 [Article Type] Article
Observational study of people infected with SARS-Cov-2, treated with amantadine아만타딘으로 치료한 SARS-Cov-2에 감염된 사람들에 대한 관찰 연구Observational Study Published on 2020-12-012022-09-11 Journal: Pharmacological Reports [Category] 임상, 치료제, [키워드] acute respiratory syndrome amantadine Antiviral Azithromycin can be used Celecoxib clinical symptom Clinical symptoms collected conducted COVID-19 infection demonstrated Effectiveness hospital IgG antibodies IgG antibody individual mechanical ventilation observational study Patient respiratory SARS-CoV-2 Severe acute respiratory syndrome Symptom the vaccine treated Treatment [DOI] 10.1007/s43440-020-00168-1 PMC 바로가기 [Article Type] Observational Study
Immunoinformatic design of a COVID-19 subunit vaccine using entire structural immunogenic epitopes of SARS-CoV-2Article Published on 2020-11-302022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] 3D structure activating approach B-cell binding complex Computational models Coronavirus disease 2019 COVID-19 cytokine disease docking effective epitope Free energy calculation high affinity highest Human immune system immune response immunogenic immunoinformatics in vivo initial linkers Molecular dynamics simulation Molecular modelling Multi-epitope vaccine non-allergenic non-toxic peptide Potential Precaution Prophylactic Protein vaccines Safe SARS-CoV-2 Side effects Spread structural proteins subunit suggested T-cell the vaccine Toll-like receptor 3 Vaccine viral infection virus [DOI] 10.1038/s41598-020-77547-4 PMC 바로가기 [Article Type] Article
COVID-19 vaccine development: What lessons can we learn from TB?Review Published on 2020-11-302022-10-28 Journal: Annals of Clinical Microbiology and Antimicrobials [Category] COVID-19, SARS, [키워드] clinical trials Complication COVID-19 COVID-19 vaccine COVID-19 vaccine development Critical death elicited evaluated feature Features highlight Immunological response Prevalence Respiratory disease SARS-CoV-2 Spread tested the SARS-CoV-2 virus the vaccine Tuberculosis tuberculosis vaccine Vaccine Vaccine development virus Wuhan, China [DOI] 10.1186/s12941-020-00402-x PMC 바로가기 [Article Type] Review
Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidateReport Published on 2020-11-272022-10-28 Journal: Science (New York, N.y.) [Category] COVID-19, [키워드] acute respiratory syndrome Analysis complexes coronavirus coronavirus disease COVID-19 ectodomain effort full-length full-length SARS-CoV-2 full-length spike protein host immune system immune response Interaction Microscopy Modification Neutralizing antibodies Novavax pandemic performed prefusion conformation provide responsible reveal SARS-CoV-2 SARS-CoV-2 spike glycoprotein Science Spike protein spike trimers stability Structure structures subunit the S1 subunit the vaccine Trimeric spike protein Vaccine vaccine candidate Vaccine development virus [DOI] 10.1126/science.abe1502 PMC 바로가기 [Article Type] Report
Multiepitope Subunit Vaccine Design against COVID-19 Based on the Spike Protein of SARS-CoV-2: An In Silico AnalysisResearch Article Published on 2020-11-192022-10-29 Journal: Journal of Immunology Research [Category] COVID-19, MERS, SARS, [키워드] activity acute respiratory syndrome Analysis association candidate vaccine caused cholera complex conducted coronavirus COVID-19 COVID-19 disease develop EAAAK linker epitope Epitopes feasible flexible globe GPGPG linkers Health HLA hydrogen bonds in vitro experiment in vivo Interaction molecular docking analysis multiepitope vaccine N-terminus positive protective immunity Safe SARS-CoV-2 sequence spike glycoprotein stability subunit suggested Support the Spike the vaccine toxin Vaccine was performed [DOI] 10.1155/2020/8893483 PMC 바로가기 [Article Type] Research Article
Parents’ and guardians’ views on the acceptability of a future COVID-19 vaccine: A multi-methods study in EnglandArticle Published on 2020-11-172022-10-29 Journal: Vaccine [Category] COVID-19, MERS, [키워드] acceptance Affect affected approach Asian black Child children Chinese common coronavirus COVID-19 COVID-19 pandemic COVID-19 vaccination programme COVID-19 vaccine cross-sectional survey Effectiveness Efficacy England Ethnicity Factor finding group MOST Other parent participant Participants predictor Prevent refusal reported response survey tested the vaccine Vaccine white [DOI] 10.1016/j.vaccine.2020.10.027 PMC 바로가기 [Article Type] Article
Analysis and Evaluation of COVID-19 Web Applications for Health Professionals: Challenges and OpportunitiesArticle Published on 2020-11-072022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] acquisition addition Analysis analyst API application can be used challenge changes in clinical trials Community complex COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 research Critical Dashboard dimension feature Government greater Health Healthcare system help impacted information interface International organizations knowledge management Metadata opportunity outcome pandemic professional provided Regulation Repository required Research researcher selected the vaccine Treatment virus Visualization Web [DOI] 10.3390/healthcare8040466 PMC 바로가기 [Article Type] Article
Pandemic and vaccine coverage: challenges of returning to schoolsComment Published on 2020-11-052022-10-29 Journal: Revista de Saúde Pública [Category] COVID-19, MERS, SARS, [키워드] age Brazil children Cobertura Vacinal coronavirus disease Coronavirus infections country Coverage Diseases Doenças Preveníveis por Vacina dropped Health services immunization coverage immunization programs Infecções por Coronavirus measure mitigate Pandemia pandemic prevenção & controle Prevention & control Program Programas de Imunização recorded School social distancing susceptible the vaccine Transmission vaccination Vaccine vaccine-preventable diseases virus [DOI] 10.11606/s1518-8787.2020054003142 PMC 바로가기 [Article Type] Comment
The Brighton Collaboration standardized template for collection of key information for benefit-risk assessment of viral vector vaccinesReview article Published on 2020-11-012022-10-05 Journal: Vaccine [Category] 비임상, [키워드] assessment Benefit-risk Brighton Collaboration CEPI collaboration COVID-19 facilitate group help IMPROVE information key consideration potential safety issue Safety technology Template the vaccine Vaccine vector Viral Viral vector vaccine Viral vector vaccines viral vectors virus working [DOI] 10.1016/j.vaccine.2020.08.009 [Article Type] Review article