Key recent advances in TB vaccine development and understanding of protective immune responses against Mycobacterium tuberculosisReview Published on 2020-08-012022-10-04 Journal: Seminars in Immunology [Category] 비임상, [키워드] Adaptive immunity adolescents and adult approach BCG candidate CD4+ CD8+ clinical evaluation correlates of protection diagnostics disease drug regimens effective Efficacy effort End endpoints Epidemic Factors high risk identify immune response immune responses include Infection Infectious disease Innate immunity Innate training Mycobacterium tuberculosis Next generation vaccine novel pathogen Population positive Protective protective immune response Protein Research revaccination stimulated Strategy sustained T cells Th1/Th17 Transmission Trial trials Tuberculosis Tuberculosis (TB) Vaccine vaccine candidate Vaccine development Vaccine(s) World Health Organization [DOI] 10.1016/j.smim.2020.101431 PMC 바로가기 [Article Type] Review
CoronaVR: A Computational Resource and Analysis of Epitopes and Therapeutics for Severe Acute Respiratory Syndrome Coronavirus-2Microbiology Published on 2020-07-312022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 2019-nCoV absence accelerate approach assist B-cell can be used Candidates causative pathogen CD4 CD8 CDC characterized China Chinese circumvent codon usage components concern Coronaviruses COVID-19 COVID-19 patient cross-protective CTL diagnostic disease effective effort Emergency epitope Epitope-based vaccine Epitopes Genome genome browser genomes global effort global pandemic glycosylation help identify initial Meta-analysis MHC miRNA miRNAs Novel coronavirus outbreak performed PHEIC Phylogenetic analysis primer Primers provided Public regimens Research researcher resource respiratory SARS-CoV SARS-CoV-2 selected sgRNAs siRNA siRNAs source of infection Spread Structural analysis T-cell tested therapeutic therapeutic interventions Therapeutics treat Vaccine virus WHO World Health Organization Wuhan [DOI] 10.3389/fmicb.2020.01858 PMC 바로가기 [Article Type] Microbiology
“The post-COVID era”: challenges in the treatment of substance use disorder (SUD) after the pandemicDebate Published on 2020-07-312022-10-28 Journal: BMC Medicine [Category] COVID-19, SARS, [키워드] Addictions affected Care concerning COVID-19 COVID-19 pandemic described disorder drug facilitated Harm-reduction high-risk population Hospitalization IMPROVE include information Mortality offer pandemic promote Psychiatric Quality of life reduce reducing SARS-COV-2 infection Seven Stigma Substance use Substance use disorder substance use disorders Telemedicine Treatment unique World Health Organization [DOI] 10.1186/s12916-020-01693-9 PMC 바로가기 [Article Type] Debate
The risks of medical complacency towards poliomyelitisarticle Published on 2020-07-312024-09-01 Journal: Med J Aust [Category] 폴리오, [키워드] polio World Health Organization [Article Type] article
COVID-19: Rational discovery of the therapeutic potential of Melatonin as a SARS-CoV-2 main Protease InhibitorResearch Paper Published on 2020-07-302022-10-29 Journal: International Journal of Medical Sciences [Category] COVID-19, MERS, SARS, [키워드] ACE-2 addition angiotensin-converting enzyme 2 Anti-inflammatory antiviral activity binding site carried Cell clinical trials complexes Compound conserved coronavirus COVID-19 described disease disorder docking docking study early stage Effect Efficacy enzyme evaluated globe hospital hyper-inflammation identify immunomodulatory in silico inhibitor inhibitors Interaction Ligand maintain melatonin Molecular docking study mortality rate MPro oxidative stress pandemic PDB pharmacological Protein Data Bank raised rational design reduce SARS-CoV-2 SARS-CoV-2 main protease Sepsis similarity Spread Stage the cytokine storm the disease therapeutic potential Treatment WHO World Health Organization [DOI] 10.7150/ijms.48053 PMC 바로가기 [Article Type] Research Paper
Forecasting the Spreading of COVID-19 across Nine Countries from Europe, Asia, and the American Continents Using the ARIMA ModelsArticle Published on 2020-07-302022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Accuracy affected ARIMA Asia Brazil Bulgaria collected continent Control country COVID-19 died ECDC epidemiological error Europe European Forecasting Hungary incidence India lowest Model MONITOR New coronavirus offer parameters Patient percentage predict Prevalence prevention regions reported restrict Romania SARS-CoV-2 spreading the American continents Ukraine USA website WHO World Health Organization [DOI] 10.3390/microorganisms8081158 PMC 바로가기 [Article Type] Article
Adaptations of a Tertiary Otorhinolaryngology Head and Neck Surgery Department in Singapore during the COVID-19 OutbreakOriginal Articles Published on 2020-07-292022-10-27 Journal: The Annals of Otology, Rhinology, and Laryngology [Category] COVID-19, MERS, SARS, [키워드] adaptation approach changes in Clinical practice coronavirus COVID-19 COVID-19 outbreak Critical Department disease endoscopy Evidence head healthcare worker infection control Neck Nosocomial infection Novel coronavirus otolaryngology Otorhinolaryngology outbreak pandemic pathology Personal protective equipment reported respiratory risk Singapore surgery susceptible Tertiary upper respiratory tract World Health Organization Wuhan, China [DOI] 10.1177/0003489420946779 PMC 바로가기 [Article Type] Original Articles
Aerosol and surface contamination of SARS-CoV-2 observed in quarantine and isolation careArticle Published on 2020-07-292022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome aerosol Care center collected Contamination coronavirus coronavirus disease COVID-19 COVID-19 patients Diseases droplet precautions Evidence individuals individuals with COVID-19 Infection prevention Infectious diseases initial Isolation pandemic Precaution progressed public health emergency quarantine resulting SARS-CoV-2 SARS-CoV-2 transmission shifting spread of COVID-19 university viral infection viral shedding World Health Organization Wuhan, China [DOI] 10.1038/s41598-020-69286-3 PMC 바로가기 [Article Type] Article
Adaptations of a Tertiary Otorhinolaryngology Head and Neck Surgery Department in Singapore during the COVID-19 OutbreakOriginal Articles Published on 2020-07-292022-10-27 Journal: The Annals of Otology, Rhinology, and Laryngology [Category] [키워드] adaptation approach changes in Clinical practice coronavirus COVID-19 COVID-19 outbreak Critical Department disease endoscopy Evidence head healthcare worker infection control Neck Nosocomial infection Novel coronavirus otolaryngology Otorhinolaryngology outbreak pandemic pathology Personal protective equipment reported respiratory risk Singapore surgery susceptible Tertiary upper respiratory tract World Health Organization Wuhan, China [DOI] 10.1177/0003489420946779 PMC 바로가기 [Article Type] Original Articles
The Enigma of Low COVID-19 Fatality Rate in India인도의 낮은 COVID-19 치사율의 수수께끼Genetics Published on 2020-07-282022-08-13 Journal: Frontiers in Genetics [Category] 유전자 메커니즘, [키워드] ACE2 receptors acute respiratory syndrome coronavirus Alter angiotensin converting enzyme 2 average BCG vaccination Betacoronavirus caused circulating city coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 death environmental factor environmental factors Epigenetic evidenced Factor Factors Fatality rate genetic diversity Genetic polymorphism genetic polymorphisms Guangdong Health Organization high temperature Host Humidity hypothese ICU admission immune responses include India Indian population Innate immunity killer cell immunoglobulin-like receptors less lowest mechanical ventilation micro RNA microRNA Mutation offer pandemic pathogen Perspective Pneumonia Rate reducing reported respiratory responsible SARS-CoV-2 SARS-CoV-2 strains severity strain susceptibility the disease Transmissibility Transmission viability virulence virus WHO World Health Organization Wuhan [DOI] 10.3389/fgene.2020.00854 PMC 바로가기 [Article Type] Genetics