Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study Prognosis of COVID-19 elderly critically ill patients in the ICUResearch Published on 2021-05-142022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] 95% CI acute respiratory distress syndrome Admission age Analysis cardiovascular dysfunction Care chronic respiratory disease clinical Cohort Comorbidity COVID-19 COVID-19 pandemic Critically ill Critically ill patient database diabete diabetics Elderly patient evaluated first symptom First wave frailty Future hazard ratio Health hypertension ICU ICU admission intensive care intensive care unit International Intubated intubation management median Mortality Old patients older patient older patients outcome PaO Patient patients older Prognosis reached reported resources Result scale significantly higher supplementary material with COVID-19 [DOI] 10.1186/s13613-021-00861-1 PMC 바로가기 [Article Type] Research
Is lung ultrasound score a useful tool to monitoring and handling moderate and severe COVID-19 patients in the general ward? An observational pilot studyObservational Study Published on 2021-05-042022-10-04 Journal: Journal of clinical monitoring and computing [Category] MERS, 임상, [키워드] Admission BMI Body Characteristics Chest computed tomography Computed tomography correlated COVID-19 CT scan CT scans cutoff value Diagnosis diagnostic died disease Exploratory analysis females Follow-up Forward handling index initial invasive ventilation Italy lung Lung ultrasound male management mass median moderate moderate-severe moderate-to-severe COVID-19 pneumonia Non invasive ventilation Noninvasive ventilation PaO Patient performed pilot study positive Predictive prognostic progression receiving Respiratory failure severe COVID-19 patient shown significantly significantly higher team the disease university [DOI] 10.1007/s10877-021-00709-w PMC 바로가기 [Article Type] Observational Study
8806 Russian patients demonstrate T cell count as better marker of COVID-19 clinical course severity than SARS-CoV-2 viral loadArticle Published on 2021-05-032022-10-04 Journal: Scientific Reports [Category] SARS, 임상, [키워드] Analysis applicability Asymptomatic carrier Clinical course Clinical practice Course COVID-19 demonstrated disease Infectious diseases investigated marker PaO Patient Prognosis SARS-CoV-2 SARS-CoV-2 viral load severity severity and prognosis Signs and symptoms T cell T lymphocyte [DOI] 10.1038/s41598-021-88714-6 PMC 바로가기 [Article Type] Article
Continuous renal replacement therapy with the addition of CytoSorb cartridge in critically ill patients with COVID-19 plus acute kidney injury: A case-seriesCOVID-19와 급성 신장 손상이 있는 중환자에서 CytoSorb 카트리지를 추가하여 지속적인 신대체 요법: 사례 시리즈Article Published on 2021-05-012022-09-11 Journal: Artificial organs [Category] MERS, SARS, 바이오마커, [키워드] 95% CI acute kidney Acute kidney injury acute respiratory distress acute respiratory distress syndrome addition Admission AKI Analysis analyzed Antibiotics anticoagulation APACHE ARDS arterial pressure assessment body mass body mass index C-reactive protein cartridge chronic Concentration Continuous Continuous renal replacement therapy continuous renal replacement therapy with cytosorb COVID-19 COVID-19 patient Critically ill critically ill COVID-19 patients Critically ill patient CRRT CRS cutoff point Cytokine release syndrome Cytosorb D-dimers Duration enrolled ferritin function Hospital mortality Hydrocortisone hyperinflammation ICU ICU admission in-hospital mortality inflammatory biomarkers intensive care interferon interferon beta Interferon beta-1b interleukin interleukin-6 Lactate lactate dehydrogenase life-threatening lymphocyte Lymphocyte count lymphocyte counts male mechanical ventilation Mortality nonsurvivors organ function oxygen Oxygenation PaO Patient Physiology predicted prone positioning Prophylactic prophylactic anticoagulation provided Pulmonary emboli renal replacement therapy replacement therapy respiratory distress Respiratory distress syndrome retrospective ribavirin Safe Sepsis Septic shock Shock Side effect SOFA SOFA scores survivor Survivors syndrome therapy Thromboembolism Ventilation were recorded with COVID-19 [DOI] 10.1111/aor.13864 PMC 바로가기 [Article Type] Article
Therapeutic plasma exchange in patients with life-threatening COVID-19: a randomised controlled clinical trialRandomized Controlled Trial Published on 2021-05-012022-10-04 Journal: International journal of antimicrobial agents [Category] 임상, [키워드] 95% CI acute respiratory distress syndrome addition age Analysis ARDS assessment association Care clinical trial COVID-19 COVID-19 patients Cytokine release syndrome D-dimer Day distress Efficacy enrolled faster clinical recovery ferritin hyperinflammation ICU ICU patient inflammatory biomarkers intensive care unit interleukin-6 IQR Kaplan-Meier lactate dehydrogenase life-threatening LOS lymphocyte Mortality Multivariable regression analysis on mechanical ventilation Open-label Organ failure outcome PaO Patient plasma positive predictor provided randomised randomised controlled reduction in RT-qPCR secondary Sepsis serum lactate SOFA score Standard standard care standard treatment stratified Therapeutic plasma exchange therapy Thromboinflammation TPE Treatment [DOI] 10.1016/j.ijantimicag.2021.106334 PMC 바로가기 [Article Type] Randomized Controlled Trial
Risk Factors for Mortality in COVID-19 Hospitalized Patients in Piedmont, Italy: Results from the Multicenter, Regional, CORACLE RegistryArticle Published on 2021-05-012022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95%CI adjusted odds ratio Admission age C-reactive protein cardiovascular disease cohort of patient COVID-19 diabete evaluate Evidence Factor female glomerular filtration rate HCQ higher risk hospital hydroxichloroquine Hydroxychloroquine Immunosuppression IQR limitations median age Mortality multicenter multivariable logistic regression PaO Patient Piedmont Pneumonia Prognostic factor randomized studies Range reduced Regional registry Result retrospective risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positive patients significantly Treatment [DOI] 10.3390/jcm10091951 PMC 바로가기 [Article Type] Article
Compassionate use of ruxolitinib in patients with SARS-Cov-2 infection not on mechanical ventilation: Short-term effects on inflammation and ventilation기계적 환기가 아닌 SARS-Cov-2 감염 환자에서 룩소리티닙의 동정적 사용: 염증 및 환기에 대한 단기 영향Article Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 신약개발, [키워드] accompany affected Anti-inflammatory anti-inflammatory drug anti-inflammatory effect Antiviral appear approach baseline benefit Biomarkers biomarkers of inflammation C-reactive protein C-reactive protein (CRP Chain Reaction clinical pharmacology clinical response collected compassionate use compassionate-use contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection criteria CRP Cytokines during treatment Dyspnea Effect effective Evidence hyperinflammation Hypothesis immune cells inclusion criteria Infection Inflammation Inflammatory response inhibit interferons interstitial pneumonia invasive ventilation JAK inhibitor jak inhibitors Jak-STAT janus Janus kinase less Lungs management mechanical ventilation mmHg need for oxygen oxygen oxygen saturation oxygen support PaO pathway Patient patients hospitalized patients with SARS-CoV-2 polymerase chain polymerase chain reaction positive present pro-inflammatory pro-inflammatory cytokines prognostic progression provided reduce reduced reduction reinforcement respiratory Respiratory function ruxolitinib SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome Side effect significantly more STAT Support Symptom systemic inflammation target the disease therapeutic therapeutic agent therapeutic agents Topic Treatment type I interferon type I interferons Ventilation were recorded [DOI] 10.1111/cts.12971 PMC 바로가기 [Article Type] Article
Implementation of Tele-ICU during the COVID-19 pandemicObservational Study Published on 2021-04-302022-10-05 Journal: Revista da Sociedade Brasileira de Medicina Tropic [Category] SARS, 임상, [키워드] admitted to ICU Care Clinical data COVID-19 COVID-19 pandemic critically ill patients Diabetes Mellitus English evaluated feasible Follow-up Health hypertension ICU ICU admission implementation in-hospital mortality Invasive mechanical ventilation IQR lung-protective ventilation male median median age Mortality pacientes com COVID-19 Pandemia pandemic PaO PaO2/FiO2 ratio participant Patient patients patients with COVID-19 platform Prevalence professional provided public health Retrospective analysis study period UTI were recorded [DOI] 10.36416/1806-3756/e20200545 PMC 바로가기 [Article Type] Observational Study
Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation호흡기 장애, 중증 폐렴 및 과염증이 있는 COVID-19 환자에서 IL-1 및 IL-6 차단에 대한 반응 예측Clinical Trial Published on 2021-04-292022-08-13 Journal: Frontiers in Immunology [Category] MERS, SARS, 임상, 진단, [키워드] administration Anakinra anti-cytokine therapy anti-cytokine therapy initiation coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 patient Cytokines Efficacy Evidence evidence of Follow-up hyper-inflamed COVID-19 patient hyper-inflamed COVID-19 patients identify IL-1 IL-6 IL-6 blockade IL-6 blocking inhibitor initiated interleukin interleukin (IL)-1 interleukin-1 interleukin-6 median Mortality objective PaO Patient patients treated pro-inflammatory cytokine pro-inflammatory cytokines provided reduced respiratory Respiratory failure respiratory impairment response Restraining maladaptive inflammation Result sarilumab SARS-CoV-2 selective severe coronavirus disease severe hyper-inflamed COVID-19 patients severe respiratory failure significantly higher Standard of care Standard therapy stratified survival survival rate therapeutic therapy Tocilizumab treat treated Treatment treatment failure treatment initiation treatment with biologics window [DOI] 10.3389/fimmu.2021.675678 PMC 바로가기 [Article Type] Clinical Trial
Telemanagement of Home-Isolated COVID-19 Patients Using Oxygen Therapy With Noninvasive Positive Pressure Ventilation and Physical Therapy Techniques: Randomized Clinical TrialRandomized Controlled Trial Published on 2021-04-282022-10-04 Journal: Journal of Medical Internet Research [Category] MERS, SARS, 임상, [키워드] approach arterial blood baseline BiPAP blood pressure Care caused Chest computed tomography clinical Course COVID-19 COVID-19 pandemic COVID-19 patient early-stage COVID-19 effective Effectiveness Final Follow-up group Health Health care system help hospital hospitals in both group in both groups management manipulative noninvasive positive airway pressure objective osteopathic medicine outcome measure oxygen saturation Oxygen therapy PaO Patient physical Physical therapy Pneumonia positive airway pressure positive response pressure prophylactic treatment randomized clinical trial Registration reliability respiratory rate Result SARS-CoV-2 SARS-COV-2 infection Satisfaction Significant significant difference Stress Support telemanagement Telemedicine teletherapy temperature the patient therapy treated Treatment two group Ventilation vital sign were given were used [DOI] 10.2196/23446 PMC 바로가기 [Article Type] Randomized Controlled Trial