[Prise en charge médicale du Covid-19, hors réanimation]Article Published on 2022-05-012023-07-10 Journal: La Revue du praticien [Category] COVID19(2023년), [키워드] Antibodies, Monoclonal Antiviral agents COVID-19
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues설폰아미드 기반 이기질 유사체에 의한 SARS-CoV-2 nsp14 N 7-메틸트랜스퍼라제의 강력한 억제Article Published on 2022-04-282022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] analogue Antiviral agents cofactor Compound demonstrated docking Enzymes human RNA inhibition inhibitor inhibitory activity Innate immunity involved mechanism of action methyl group molecular docking mRNAs nsp14 nucleoside potent RNA SAM SARS-CoV-2 significantly stability supported synthesis target the SARS-CoV-2 transfer translation Viral RNA virus [DOI] 10.1021/acs.jmedchem.2c00120 PMC 바로가기 [Article Type] Article
Synthesis and Applications of Nitrogen-Containing Heterocycles as Antiviral AgentsReview Published on 2022-04-222023-07-01 Journal: Molecules [Category] COVID19(2023년), SARS, [키워드] Antiviral agents COVID-19 inhibition nitrogen-containing heterocycles synthesis viruses [DOI] 10.3390/molecules27092700 PMC 바로가기 [Article Type] Review
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvirSARS-CoV-2 변이체의 주요 프로테아제 돌연변이체는 여전히 니르마트렐비르에 감수성입니다Article Published on 2022-04-152022-09-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] anticipated antiviral agent Antiviral agents B.1.1.529 B.1.351 Beta catalytically competent Coronaviral COVID-19 COVID-19 pandemic drug target Effectiveness Efficacy expressed in vitro data inhibitor inhibitors Lambda M pro main protease Missense mutation Multiple multiple mutations mutant Mutation Nirmatrelvir not compromised omicron P.2 PF-07321332 prevalent protease public health threat SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant Specific Spike protein susceptible the spike protein Vaccines variant variants variants of SARS-CoV-2 wildtype [DOI] 10.1016/j.bmcl.2022.128629 PMC 바로가기 [Article Type] Article
Novel antiviral activity of PAD inhibitors against human beta-coronaviruses HCoV-OC43 and SARS-CoV-2인간 베타 코로나바이러스 HCoV-OC43 및 SARS-CoV-2에 대한 PAD 억제제의 새로운 항바이러스 활성Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] African green monkey Antiviral antiviral activity Antiviral agents Antiviral compounds beta-coronavirus calcium Cell Citrullination coronavirus COVID-19 patients develop effective Efficacy enzyme Factor family fetal fibroblast green monkey HCoV HCoV-OC43 HCoVs highlight Host-targeting antivirals Infection inhibitor inhibitors inhibitory activity kidney likelihood lung New coronavirus novel OC43 Peptidyl-arginine deiminases Protein rationale Replication repurposing SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 replication specific inhibitor strain suppresse transcriptional activation Treatment treatment of COVID-19 patients Vero-E6 cells viral replication [DOI] 10.1016/j.antiviral.2022.105278 PMC 바로가기 [Article Type] Article
An in-silico analysis of ivermectin interaction with potential SARS-CoV-2 targets and host nuclear importin α잠재적인 SARS-CoV-2 표적 및 숙주 핵 임포틴 α와의 이버멕틴 상호작용에 대한 인-실리코 분석Article Published on 2022-04-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] accounted Analysis antiparasitic Antiviral agents assist AutoDock AutoDock vina binding binding energy complex complexes COVID-19 deviation docked docking drug target drugs exhibited fluctuation Host in vitro in-silico inhibitory interacting residue Interaction Ivermectin mechanism of action moderate molecular molecular docking molecular dynamics Molecular dynamics simulation Molecular mechanics NLS non-structural protein Nsp9 nuclear nuclear localization signal Protein protein-ligand root SARS-CoV-2 SARS-CoV-2 replication surface area target targets trajectory viral infections with COVID-19 [DOI] 10.1080/07391102.2020.1841028 PMC 바로가기 [Article Type] Article
Baricitinib combination therapy: a narrative review of repurposed Janus kinase inhibitor against severe SARS-CoV-2 infectionReview Published on 2022-04-012022-10-04 Journal: Infection [Category] COVID19(2023년), SARS, 신약개발, [키워드] age antiviral agent Antiviral agents Baricitinib cellular cellular signaling pathway Combination combination therapy Coronavirus disease 2019 COVID-19 COVID-19 infection Cytokine storm disease-specific treatments Drug-drug interactions dysregulated immune response Effect Effectiveness form Google Hospitalized hospitalized patient Infection Inflammatory response inhibitor Jak Janus kinase Janus kinase pathway lack moderate modulate outcome pandemic pathway Pediatric patient positive pro-inflammatory problems repurposing Repurposing drug therapy resulting severe COVID-19 severe COVID-19 patient severe SARS-CoV-2 severity of COVID-19 shown Standard of care subcellular synergistic therapeutic Therapeutic approach therapy Treatment virus entry [DOI] 10.1007/s15010-021-01730-6 PMC 바로가기 [Article Type] Review
Effective Reduction of SARS-CoV-2 RNA Levels Using a Tailor-Made Oligonucleotide-Based RNA Inhibitor맞춤형 올리고뉴클레오티드 기반 RNA 억제제를 사용한 SARS-CoV-2 RNA 수준의 효과적인 감소Article Published on 2022-03-252022-09-11 Journal: Viruses [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral agents caused cellular coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Efficiency inhibitor lack Level lung cell lines management oligonucleotide oligonucleotide-based RNA inhibitor. pandemic patients hospitalized priority public health RdRP reducing RNA RNA levels RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus therapeutic with COVID-19 [DOI] 10.3390/v14040685 PMC 바로가기 [Article Type] Article
Improved Binding Affinity of Omicron’s Spike Protein for the Human Angiotensin-Converting Enzyme 2 Receptor Is the Key behind Its Increased Virulence인간 안지오텐신 전환 효소 2 수용체에 대한 오미크론 스파이크 단백질의 향상된 결합 친화도는 독성 증가의 핵심입니다Article Published on 2022-03-212022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affinity Amino acid amino acid residue amino acids angiotensin Antiviral agents binding binding free energies binding free energy characterized complex contribute coronavirus country D38 domain electrostatic interaction enzyme exhibited free energy genomic region hACE2 hACE2 receptor Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human angiotensin-converting enzyme 2 (hACE2) hydrogen hydrogen bonding Improved Increased information Interaction investigated mode molecular molecular dynamics Molecular dynamics simulation Molecular mechanics molecular mechanics-generalized Born surface area (MM-GBSA) mutated Mutation omicron Omicron variant Other pi-stacking RBD receptor Receptor-binding domain Receptor-binding domain (RBD) receptor-binding motif Receptor-binding motif (RBM) residue resulting salt bridges SARS-CoV-2 SARS-CoV-2 RBD Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) spike Spike protein surface area the RBD the spike protein Transmissibility tyrosine variant variant of SARS-CoV-2 virus wild type [DOI] 10.3390/ijms23063409 PMC 바로가기 [Article Type] Article
Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in miceArticle Published on 2022-03-182023-06-15 Journal: Communications Biology [Category] MERS, SARS, [키워드] Antiviral agents SARS-CoV-2 Virus-host interactions [DOI] 10.1038/s42003-022-03189-z PMC 바로가기 [Article Type] Article