Antiviral effect – Page 14 – Communicable Diseases Research

Assessment of Antiviral Coatings for High-Touch Surfaces by Using Human Coronaviruses HCoV-229E and SARS-CoV-2

Methods

Published on 2021-07-212022-10-28
Journal: Applied and Environmental Microbiology [Category] COVID-19, SARS,

Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

프로테아제 억제제를 사용한 감염 후 치료는 치명적인 SARS-CoV-2 감염이 있는 생쥐의 생존을 증가시킵니다

Comparative Study

Published on 2021-07-202022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 변종, 신약개발, 진단, 치료제,

[키워드] 3CLpro acute respiratory syndrome acute respiratory syndrome coronavirus ameliorated animal models Antiviral antiviral agent Antiviral agents antiviral drug Antiviral effect assays binding interaction binding interactions causative agent Cell culture change Compound coronavirus COVID-19 develop dose effective Efficacy enzyme evaluated global public health High-resolution histopathological human coronavirus human coronaviruses in vitro assays increase increased survival Infection inhibiting inhibitor inhibitory activity K18-ACE2 mice K18-hACE2 mice lethal infection Lung pathology mice Mild Postinfection potency protease Protease inhibitor protease inhibitors Replication reported respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 patient severe COVID-19 patients Significance significantly increased survival therapeutic efficacy therapeutic option transgenic mice treated Treatment variant Viral virus virus replication virus titer virus titers were used
[DOI] 10.1073/pnas.2101555118 PMC 바로가기 [Article Type] Comparative Study

Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2

아르보바이러스, 엔테로바이러스 및 SARS-CoV-2에 대한 새로운 광범위한 항바이러스 전략으로서의 Nodosome 억제

Article

Published on 2021-07-162022-09-11
Journal: Antimicrobial Agents and Chemotherapy [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alphaviruses Antiviral antiviral activity Antiviral effect arbovirus Arboviruses Brain broad spectrum broad-spectrum antiviral broad-spectrum antivirals causative agent Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 coxsackievirus downstream drug enhancement expression fetal function Host induce Infection inhibit inhibition inhibitor interferon interferon response NOD2 nodosome. novel nucleotide observation oligomerization pathogenic promote Protein protein kinase Replication RIPK2 RNA viruses SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus shown small molecule Spread Strategy target the interferon threonine Zika virus ZIKV
[DOI] 10.1128/AAC.00491-21 PMC 바로가기 [Article Type] Article

Plitidepsin: Mechanisms and Clinical Profile of a Promising Antiviral Agent against COVID-19

Review

Published on 2021-07-162022-10-30
Journal: Journal of Personalized Medicine [Category] COVID-19,

[키워드] accelerate acting administration affected agent anti-SARS-CoV-2 anticipated Antiviral Antiviral agents Antiviral effect antiviral property aplidin B.1.1.7 variant clinical Clinical data clinical evidence Combination COVID-19 current database demonstrated Dexamethasone effective Efficacy Ex vivo hospital hospitalized COVID-19 patients hospitalized patients Host inhibiting interactions intravenous isoform knowledge lack lineages mechanism multicentre Multiple myeloma Patient Plitidepsin Population profile regimen Remdesivir safety profile SARS-CoV-2 Standard of care standard treatment suggested translation Treatment Trial viral load reduction Viral proteins
[DOI] 10.3390/jpm11070668 PMC 바로가기 [Article Type] Review

Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation

Research

Published on 2021-07-152022-10-05
Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 바이오마커, 치료제,

[키워드] ACE2 activated acute inflammatory response acute lung inflammation acute respiratory distress acute respiratory syndrome Administered administration AGT alleviate alteration antiviral activity Antiviral effect Cell controls coronavirus COVID-19 patient damaged EC50 entry of SARS-CoV-2 expressed expression HEK-293T cell in vitro in vivo induce infected with SARS-CoV-2 Infection inflammatory cell infiltration Inflammatory cytokines inhibit inhibited intravenous investigated low expression lung inflammatory response lung tissue mechanism mice Mortality mRNA level NF-κB Potential treatment progression respiratory inflammation Salvia miltiorrhiza SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S syndrome target cells Therapeutics TLR4 treated Treatment VERO-E6 virus virus assay VSV-G
[DOI] 10.1038/s41401-021-00714-4 [Article Type] Research

Pharmacokinetic interactions between the potential COVID-19 treatment drugs lopinavir/ritonavir and arbidol in rats

Article

Published on 2021-07-152022-10-04
Journal: Journal of Zhejiang University. Science. B [Category] SARS, 신약개발,

Strategies to target SARS-CoV-2 entry and infection using dual mechanisms of inhibition by acidification inhibitors

산성화 억제제에 의한 이중 억제 메커니즘을 사용하여 SARS-CoV-2 진입 및 감염을 표적으로 하는 전략

Research Article

Published on 2021-07-122022-09-10
Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 Acidic Affect Alter Antiviral effect applicability assist attenuate Cell cells cellular mechanism cellular mechanisms Chloroquine clathrin Clathrin-mediated endocytosis Clinical management drug ectopic expression endocytic Endocytic pathway endosomal Endosomal acidification endosomal pH expressing expression FDA-approved drug FDA-approved drugs Host host cell host cells human cells Infection inhibit inhibitor mechanism neutralize niclosamide observation pathway Prevent RBD Receptor binding domain reduce SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 spike protein screened Spike protein Strategy subset Therapeutic strategies tracing undetectable Vero Cell Vero cells Viral viral entry viral infections virus viruses
[DOI] 10.1371/journal.ppat.1009706 PMC 바로가기 [Article Type] Research Article

Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air–Liquid Interface Cultured Human Primary Bronchial Epithelial Cells

레스베라트롤 및 피터 스틸 벤은 공기-액체 계면 배양 인간 1 차 기관지 상피 세포에서 SARS-COV-2 복제를 억제합니다.

Article

Published on 2021-07-102022-09-10
Journal: Viruses [Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added African green monkey air–liquid interface Anti-inflammatory antioxidant Antiviral antiviral activity Antiviral compound Antiviral compounds Antiviral effect antiviral property antiviral therapy bronchial bronchial epithelial cells caused cells clinical trial clinical trials Compound conditions coronavirus COVID-19 COVID-19 pandemic COVID-19 treatment drug Economy epithelial cells Evidence FIVE green monkey Health healthy volunteers Human human primary bronchial epithelial cells in vitro infected cell infected cells Infection inhibit inhibit SARS-CoV-2 initial interface kidney Laboratory laboratory findings long-lasting Post-infection progeny pterostilbene reduced Replenishment Replication researcher respiratory resveratrol SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication second severe acute respiratory syndrome Coronavirus therapeutic options these cell These cells these compound these compounds Treatment upper respiratory tract virus virus replication
[DOI] 10.3390/v13071335 PMC 바로가기 [Article Type] Article

Research Progress on the Antiviral Activity of Glycyrrhizin and its Derivatives in Liquorice

Pharmacology

Published on 2021-07-062022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study

무작위 대조 시험에서 합리적인 샘플 크기로 COVID-19에 대한 유의 한 항 바이러스 약물 효과의 검출 : 모델링 연구

Research Article

Published on 2021-07-062022-09-10
Journal: PLoS Medicine [Category] SARS, 임상, 치료기술, 치료제,

[키워드] 1:1 95% CI acute respiratory syndrome coronavirus added analyzed Antiviral antiviral drug antiviral drugs Antiviral effect Antiviral treatment approach association assumed calibrated candidate drug characterized Clinical studies clinical study clinical trial clinical trials cluster analysis Clustering compassionate use conducted confounding variable Controlled trial coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 cumulative demonstrated detect detection development Effect effective enrolled Evidence feature group groups Health help heterogeneity in viral in vitro in vivo models inclusion criteria infected individuals initiated investigated lack log mean difference mechanism methodology mimicking MOST observational studies observational study observé outcome P -value parameter Patient placebo group quantified randomization Randomized Randomized controlled trial Randomized controlled trials recruit reduced reduction in required researcher respiratory Sample size sample size estimates sample sizes SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Simulation small sample size statistically significant Study design symptom onset Symptoms the timing time lag treated Treatment treatment allocation treatment initiation trials Viral viral dynamics Viral load viral replication virus Virus shedding was reduced
[DOI] 10.1371/journal.pmed.1003660 PMC 바로가기 [Article Type] Research Article