Spatiotemporal dynamics of effector CD8+ T cell responses within the liverReview Published on 2016-01-012023-06-16 Journal: Journal of leukocyte biology [Category] B형 간염, [키워드] antiviral immunity Intravital imaging leukocyte trafficking tissue immunosurveillance. [DOI] 10.1189/jlb.4MR0415-150R PMC 바로가기 [Article Type] Review
Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclin1 to negatively regulate antiviral innate immunityResearch Article Published on 2014-10-152022-10-29 Journal: Protein & Cell [Category] Coronavirus, [키워드] Antiviral antiviral immune response antiviral immunity autophagic autophagy Beclin1 coronavirus coronavirus Coronavirus replication Host IFN signaling induce Infection inhibitory effect Innate immunity interact Interaction knockdown Lysosomes mechanism modulate modulating Papain-like protease PLP2 promote Protein regulate Regulation responses resulting STING suggested turn viral replication [DOI] 10.1007/s13238-014-0104-6 PMC 바로가기 [Article Type] Research Article
Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic북미 전염병 동안 숙주 인구에 대한 HIV-1 적응의 유전형 및 기능적 영향Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate adaptation analyzed Antiviral antiviral immunity assessment average Boston cellular immunity changes in characterized circulating codon Cohort Consensus consequence detectable enrolled Epidemic ERAS escape mutation Evolution exhibiting explain Frequency functional Gag greater HIV HIV-1 HLA Host immune immune escape mutation immune escape mutations Impact implication in vitro Increases individual information median medians Mutation New York North North America Patient persistence phenotypic Phylogeny polymorphism Polymorphisms Population Protective Protein reconstructed reduce remained replication capacity residue Result San Francisco selected sequence specimen Spread subsequent suggested Support the epidemic the median Transmission unlikely Viral viral fitness Viral proteins virus [DOI] 10.1371/journal.pgen.1004295 PMC 바로가기 [Article Type] Research Article
Protective Role of Toll-like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of MacrophagesArticle Published on 2012-05-242022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation adaptive antigen-presenting cell antiviral immunity antiviral state chemokines chronic infection coronavirus CoV CoVs Cytokines diminishe Express IFN-β IFNs Immunity induce infancy infect Infection investigation Ligand Macrophage macrophage cell line macrophages MHV MHV-A59 mouse hepatitis virus murine murine coronavirus not affect pattern recognition receptor Poly I:C positive-sense PRR PRRs RNA virus role selected single-stranded Stimulation suppresse susceptibility TLR TLR2 TLR3 TLR4 TLR7 TLRs triggering Type Type I IFN type I interferon viral infection viral infections virus production viruses [DOI] 10.3390/v4050901 PMC 바로가기 [Article Type] Article