Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease매일 고용량 경구 비타민 D 요법이 코로나19 환자의 염증 표지자에 미치는 영향Randomized Controlled Trial Published on 2021-05-202022-08-13 Journal: Scientific Reports [Category] 바이오마커, 임상, 치료법, [키워드] added addition adjunctive Pulse D therapy analysed Biochemistry BMI COVID 19 COVID-19 COVID-19 patient CRP difference disease Diseases dysregulation evaluated ferritin group groups High dose Hypovitaminosis D IL6 immune dysregulation immunomodulator Impact Inflammatory marker inflammatory markers LDH marker Microbiology N/L ratio outcomes Pathogenesis Patient Pulse D therapy randomised reduced reducing reduction Seven Side effects significantly standard treatment standard treatment alone statistical significance subject Therapeutic improvement therapy Treatment protocol treatment protocols two group two groups variable Vitamin D vitamin D level with COVID-19 [DOI] 10.1038/s41598-021-90189-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failureArticle Published on 2021-05-182022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] abnormality accumulating Acute respiratory failure Admission alteration Analysis ANOVA applied ARF association bile acids Bioavailability Biochemistry Biomarkers biosynthetic change characterized cofactor Critically ill patient detect determine disorders dysfunction Efficiency Evidence FDR high accuracy hospital discharge include intensive care mechanical ventilation Medical research metabolism metabolite metabolome metabolomic mitochondrial morbidity and mortality Mortality NADP nicotinamide adenine dinucleotide non-survivor outcome pathway Patient phosphate predict predicted Prevalence Quantitative reduce mortality Respiratory failure Riboflavin semi-quantitative Sepsis serum severity Significant substrate survival survivor Survivors Systems biology target Treatment [DOI] 10.1038/s41598-021-89716-0 PMC 바로가기 [Article Type] Article
Lenalidomide downregulates ACE2 protein abundance to alleviate infection by SARS-CoV-2 spike protein conditioned pseudovirusesLetter Published on 2021-05-102022-10-29 Journal: Signal Transduction and Targeted Therapy [Category] COVID-19, Fulltext, SARS, [키워드] ACE2 protein alleviate Biochemistry Cell Biology conditioned downregulate Infection lenalidomide pseudovirus SARS-CoV-2 spike protein [DOI] 10.1038/s41392-021-00608-1 PMC 바로가기 [Article Type] Letter
Analysis of laboratory blood parameter results for patients diagnosed with COVID‐19, from all ethnic group populations: A single centre studyOriginal Article Published on 2021-05-032022-10-30 Journal: International journal of laboratory hematology [Category] COVID-19, MERS, SARS, [키워드] Admission age Analysis Asian Bame Biochemistry black Blood Caucasian changes in clinician collected COVID diagnosis COVID‐19 COVID‐19 infection COVID‐19 death diabete diabetes Diabetic diagnosed died Ethnic groups Factor ferritin fibrinogen groups Haematology help Hypothesis Intensive Interaction Intervention Laboratory laboratory investigation Linear model Metrics Mortality mortality indicators obesity Odds ratio parameter Patient positive predict Prognosis Prognostic factor reduce reduce mortality Result secondary care Sex Survivors tested [DOI] 10.1111/ijlh.13538 PMC 바로가기 [Article Type] Original Article
Aerosol Production During Blood and Urine Pre-analytical Processing and Handling in a Hospital Biochemistry Clinical Laboratory During the COVID-19 PandemicPublic Health Published on 2021-04-212022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] aerosol aerosol exposure Aerosol generation appear Bioaerosols Biochemistry Blood blood sample clinical clinical laboratory conducted COVID-19 Laboratory occupational risk Other Patient processing Production reported risk SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 RNA swabbing Treatment undetectable Urine urine sample [DOI] 10.3389/fpubh.2021.643724 PMC 바로가기 [Article Type] Public Health
Carbohydrate binding module-fused antibodies improve the performance of cellulose-based lateral flow immunoassays탄수화물 결합 모듈 융합 항체는 셀룰로오스 기반 측면 흐름 면역 분석의 성능을 향상시킵니다.Article Published on 2021-04-122022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 진단, 치료기술, [키워드] antibodies antibody antibody fragment binding Biochemistry Biotechnology carbohydrate Cellulose demonstrated detect detection antibody diagnostics Effect environmental factors food safety implementation IMPROVE Infection lateral flow lateral flow immunoassay Lateral flow immunoassays Lateral flow test Molecular biology nitrocellulose nitrocellulose membranes outbreak pandemic parameters POC Pregnancy Protein Protein binding SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody sensitivity serum specific antibodies sustainability Urine [DOI] 10.1038/s41598-021-87072-7 PMC 바로가기 [Article Type] Article
Correlations between chest-CT and laboratory parameters in SARS-CoV-2 pneumonia A single-center study from ItalyObservational Study Published on 2021-04-092022-10-04 Journal: Medicine [Category] MERS, SARS, 임상, [키워드] absence Admission affected age Analysis analyzed biochemical parameter Biochemistry Biomarkers blood cell count C-reactive protein Chest computed tomography Chest CT Corona COVID-19 COVID-19 epidemic COVID-19 group CRP CT scan d -dimer damaged diagnostic double negative evaluate feature females fibrinogen fibrinogen level group in both group interstitial pneumonia Italy Laboratory laboratory parameter lactate dehydrogenase LDH lung lung damage Lymphocytes male nasopharyngeal negative RT-PCR Novel coronavirus occurred Oropharyngeal pandemic Patient Pneumonia polymerase chain positive positive RT-PCR quantification real-time reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR RT-PCR assay RT-PCR test RT-PCR tests SARS-CoV 2 SARS-CoV-2 SARS-CoV-2 pneumonia single-center study statistically significant difference Swab Volume was performed were excluded with COVID-19 [DOI] 10.1097/MD.0000000000025310 PMC 바로가기 [Article Type] Observational Study
Liver injury is independently associated with adverse clinical outcomes in patients with COVID-19간 손상은 COVID-19 환자의 불리한 임상 결과와 독립적으로 연관되어 있습니다Article Published on 2021-04-012022-09-11 Journal: Gut [Category] SARS, 치료제, [키워드] 95% CI acute respiratory syndrome adjusted Admission admitted to ICU age Alanine alanine aminotransferase albumin ALT/AST aspartate Aspartate aminotransferase AST Beta Biochemistry cholestasis Clinical outcome coronavirus disease Coronavirus disease 2019 Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 patients database death defined diabete diabetes Diagnosis died HCoV HCoVs Hepatitis Hong Kong human coronavirus hypertension ICU Injury intensive care intensive care unit interferon interferon beta Invasive mechanical ventilation limit liver Liver function Liver function test Liver injury Lopinavir Lopinavir-ritonavir men occurred Patient patients patients with COVID-19 primary end point retrospective cohort study ribavirin Ritonavir SARS patient SARS patients Severe acute respiratory syndrome Virological [DOI] 10.1136/gutjnl-2020-321726 PMC 바로가기 [Article Type] Article
Studies on the mitochondrial, immunological and inflammatory effects of solvent fractions of Diospyros mespiliformis Hochst in Plasmodium berghei-infected mice디오스피로스 메스필리포르미스 호흐스트의 용매 분획이 플라스모디움 베르헤이 감염 쥐에서 미토콘드리아, 면역학적 및 염증 효과에 대한 연구Article Published on 2021-03-252024-08-08 Journal: Burma Med J [Category] 말라리아, [키워드] Biochemistry Cell Biology Drug discovery immunology [DOI] 10.1038/s41598-021-85790-6 PMC 바로가기 [Article Type] Article
In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2Article Published on 2021-03-252022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] ACE2 ACE2 receptor acute respiratory syndrome angiotensin-converting enzyme 2 angiotensin-converting enzyme-2 beta-coronavirus bind binding binding affinity binding energy Biochemistry cellular cellular receptor complex Computational biology and bioinformatics Coronaviridae coronavirus coronavirus disease Coronavirus-2 COVID-19 Critical demonstrated drug expressed facilitate functional host cell host cell receptor in silico inhibit Interaction Lung epithelial cells management mechanism membranes Mutation occurred pandemic performed Protein–protein interaction receptor-binding motif responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein spike glycoprotein Spread the receptor-binding domain Treatment viral genome viral infection [DOI] 10.1038/s41598-021-86380-2 PMC 바로가기 [Article Type] Article