Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617B.1.617에 대한 효능을 유지하는 단일특이성 및 이중특이성 단일클론 SARS-CoV-2 중화 항체Article Published on 2022-03-282022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis antibody B cell B cells B.1.617 B.1.617.2 binding patterns Breakthrough infection breakthrough infections caused clone complex conformations COVID-19 Critical cryo-EM structure cryo-EM structures death delta variant ectodomain Efficacy Epitopes expand facilitate functional generate humanized identify immunized in vivo inhibitory activity lead mAb mAbs maintain monoclonal monoclonal antibodies monoclonal antibody nanomolar affinity neutralize Neutralizing Neutralizing antibodies neutralizing antibody occur pathogen prefusion Prophylactic RBD Receptor binding domain repertoire SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant SARS-CoV-2 variants single cell sequencing Spike receptor binding domain spike trimer therapeutic therapeutic option Therapeutics translation Vaccine variants variants of concern virus [DOI] 10.1038/s41467-022-29288-3 PMC 바로가기 [Article Type] Article
Neutralizing antibody responses elicited by SARS-CoV-2 mRNA vaccination wane over time and are boosted by breakthrough infectionSARS-CoV-2 mRNA 백신 접종에 의해 유발된 중화 항체 반응은 시간이 지남에 따라 약해지고 돌발성 감염에 의해 강화됩니다Article Published on 2022-03-232022-09-11 Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] addition Alpha Antibody Response Antibody titer Antibody titers B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta BNT162b2 Booster vaccine Breakthrough infection breakthrough infections collected D614G debate declined Delta dependent on dose doses Efficacy elicited examined exhibited first vaccination FIVE HCW HCWs Health care Health care worker health care workers Infection Most patients mRNA mRNA vaccination mRNA vaccine mRNA vaccines Neutralizing antibodies neutralizing antibody Neutralizing antibody response Neutralizing antibody titer neutralizing antibody titers omicron Patient Protein pseudovirus pseudoviruses recipient recipients SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants second vaccination serum sample serum samples Spike protein the spike protein vaccination vaccine responses Vaccine-induced immunity variant variant spike variants [DOI] 10.1126/scitranslmed.abn8057 PMC 바로가기 [Article Type] Article
Variants of Concern Are Overrepresented Among Postvaccination Breakthrough Infections of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Washington State워싱턴 주에서 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)의 백신 접종 후 획기적인 감염 중 우려의 변형이 과도하게 나타남Article Published on 2022-03-232022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 치료기술, [키워드] Breakthrough infection breakthrough infections concern coronavirus 2 Infection IQR Laboratory median respiratory SARS-CoV-2 sequenced Sequencing significantly state Vaccine Vaccine breakthrough variants variants of concern VoC VOCs Washington [DOI] 10.1093/cid/ciab581 PMC 바로가기 [Article Type] Article
Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22)비강 나노바디(Nb22)에 의해 부여된 hACE2 마우스의 SARS-CoV-2에 대한 단기 순간 예방 및 효율적인 치료Article Published on 2022-03-172022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] addition Administered Against alpaca binding blocked Breakthrough infection breakthrough infections caused circulating Community Complete COVID-19 vaccine current Delta delta variant demonstrated doses effective Efficacy efficient exhibited exhibiting hACE2 highlight immunized Inhaled inoculation instantaneous instantaneous prophylaxis instantaneous protection intranasal long-lasting nanobodies nanobody Nb22 neutralization PrEP Prophylaxis RBD reported respiratory Respiratory system SARS-CoV-2 Seven single dose Spike protein stability STIP Structural analysis Structure the spike protein therapeutic unmet need variants [DOI] 10.3389/fimmu.2022.865401 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escapeSARS-CoV-2 스파이크 E156G/Δ157-158 돌연변이는 증가된 감염성과 면역 탈출에 기여합니다Article Published on 2022-03-162022-09-11 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 변종, [키워드] addition B.1.617 Breakthrough infection breakthrough infections changes in circulating coding region Combination contribute contributed D614G exhibited functional higher infectivity Immune escape Infection introduced L452R mutant Mutation mutations N-terminal domain neutralization neutralized NTD plasma Pseudotyped viruses raise reduced reported SARS-CoV-2 spike SARS-CoV-2 variant screened sensitivity sequence sequences spike gene spike mutation spike mutations spike-pseudotyped virus spike-pseudotyped viruses T19R USA vaccine-induced antibodies viral particle Viral particles [DOI] 10.26508/lsa.202201415 PMC 바로가기 [Article Type] Article
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab인플릭시맙과 베돌리주맙으로 치료받은 염증성 장질환 환자에서 SARS-CoV-2 백신 2회 투여 후 항체 붕괴, T 세포 면역 및 돌발성 감염Article Published on 2022-03-162022-09-11 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] anti-S anti-TNF antibody antibody concentration BNT162b2 Breakthrough infection breakthrough infections ChAdOx1 ChAdOx1 nCoV-19 Concentration dose drug geometric mean half-live immune responses Immunity impair induce Inflammatory bowel disease infliximab Influenza influenza vaccination integrin nCoV Necrosis of BNT162b2 p value Patient patients patients treated pneumococcal predicted protective immunity RBD required respiratory respiratory infection risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 vaccine sustained T cell T cell response treated treatment groups tumour necrosis factor U/mL vaccination vaccination schedule vaccine doses vaccine-induced immune response vedolizumab [DOI] 10.1038/s41467-022-28517-z PMC 바로가기 [Article Type] Article
SARS-CoV-2 infection and vaccination trigger long-lived B and CD4+ T lymphocytes with implications for booster strategiesSARS-CoV-2 감염 및 백신 접종은 부스터 전략에 영향을 미치는 수명이 긴 B 및 CD4+ T 림프구를 유발합니다Article Published on 2022-03-152022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Adaptive immunity anti-spike immunity antibody antibody levels booster booster dose booster injection breakthrough infections causative agent CD4+ T cell CD4+ T cells CD4+ T lymphocyte Cellular immune response cellular immunity clinical clinical medicine Cohort CoV COVID-19 COVID-19 infection decay Department detectable Florence funds humoral humoral and cellular immunity Humoral immunity immune response Immunological memory implication individual individuals infected individuals Infection injection Italian Longitudinal evaluation Medicine memory B memory cell Memory cells Ministry of Health mRNA vaccination naïve individuals natural infection neutralization capacity occur performed persistence PROTECT reduced Reinfection restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2-infected individuals severe disease significantly Spike protein supported T cells Tuscany university vaccinated individual vaccinated individuals vaccination [DOI] 10.1172/JCI157990 PMC 바로가기 [Article Type] Article
How to Deal With Vaccine Breakthrough Infection With SARS-CoV-2 VariantsSARS-CoV-2 변이체를 사용한 백신 돌발 감염에 대처하는 방법Review Published on 2022-03-152022-09-11 Journal: Frontiers in Public Health [Category] SARS, 변종, [키워드] Antibody titer breakthrough breakthrough infections Characteristics Coronary coronary pneumonia country COVID-19 COVID-19 outbreak declined declining Defense Delta effective hand hygiene highest hygiene Infection Infectious disease intensity management masking measure Measures morbidity morbidity and mortality mutant strain New York novel occurrence of COVID-19 outbreak Outbreaks Prevention and control reported SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants social distancing Strains the SARS-CoV-2 the vaccine Travel vaccination Vaccine vaccine breakthrough infections Vaccines variant variants virulent virulent strains. widespread [DOI] 10.3389/fpubh.2022.842303 PMC 바로가기 [Article Type] Review
Persistent B cell memory after SARS-CoV-2 vaccination is functional during breakthrough infectionsSARS-CoV-2 백신 접종 후 지속적인 B 세포 기억은 돌발성 감염 동안 기능합니다Article Published on 2022-03-092022-09-12 Journal: Cell Host & Microbe [Category] MERS, SARS, 진단, [키워드] antibody Antigen B cell memory BNT162b2 mRNA vaccine Breakthrough infection breakthrough infections clinical disease Cohort COVID-19 expected functional had no HCW HCWs Health care worker IgA immunization in vivo induce investigated memory B memory B cell memory B cells mRNA mRNA vaccine mucosal mucosal immunity outcome persistent physiological produced producing Saliva salivary salivary IgA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2-specific antibodies second dose serum specific antibody vaccinated individual waning immunity while [DOI] 10.1016/j.chom.2022.01.003 PMC 바로가기 [Article Type] Article
Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection증상이 있는 SARS-CoV-2 알파 감염이 있는 백신 접종 환자의 적응 면역 반응Article Published on 2022-03-082022-09-11 Journal: JCI Insight [Category] MERS, SARS, 변종, 진단, [키워드] Adaptive immunity Alpha Alpha variant antibody antibody levels Antibody titers Breakthrough infection breakthrough infections caused Cellular immune response cellular immune responses characterized Cohort COVID-19 declined defined disease ELISA Genetic variation HCs healthy control IFN-γ IgG antibody IgG antibody titers IgG titer IgG titers immune immune response immune responses infected patient infected patients Infection Infectious disease mRNA vaccination neutralization activity Neutralizing neutralizing antibody Patient protective immunity response SARS-CoV-2 SARS-CoV-2 vaccination severe disease sustained symptomatic symptomatic infection symptomatic infections symptomatic patient Symptomatic patients T cell T cell response T cell responses the SARS-CoV-2 the vaccine vaccination Viral viral variant Viral variants virus Virus neutralization virus-specific T cell [DOI] 10.1172/jci.insight.155944 PMC 바로가기 [Article Type] Article