Remote pathology education during the COVID-19 era: Crisis converted to opportunity코로나19 시대 원격 병리교육: 위기를 기회로Article Published on 2020-12-012022-08-31 Journal: Annals of diagnostic pathology [Category] MERS, SARS, 치료기술, [키워드] class Clinical practice Course COVID-19 COVID-19 pandemic crisis demonstrated diagnostic Digital digital pathology Diseases distance Distance learning effort exposure to implementation Kern's 6-step approach option Participants participated pathology provided question questionnaire remote reported selective student evaluations Support Topic Undergraduate education were given Zoom. [DOI] 10.1016/j.anndiagpath.2020.151612 PMC 바로가기 [Article Type] Article
Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposingReview article Published on 2020-12-012022-10-05 Journal: Pharmacology & therapeutics [Category] 신약개발, [키워드] Anti-cancer therapy antimalarial drug Artemisinin artemisinins artesunate Cancer class clinical trial daily dose death disease Drug repurposing greater income indicated majority middle occur oncology pandemic Pathways significantly targeting therapeutic Tolerability Treatment unique variety [DOI] 10.1016/j.pharmthera.2020.107706 [Article Type] Review article
MEMS Biosensors and COVID-19: Missed OpportunityMEMS 바이오센서와 COVID-19: 놓친 기회Article Published on 2020-11-252022-09-11 Journal: ACS Sensors [Category] SARS, 치료기술, [키워드] acceleration Analysis BioMEMS biosensor biosensors class COVID-19 criteria Diagnosis focus front line Health MEMs Missed opportunity pandemic REALITY SARS-CoV-2 scientist selective serological Society suggested Virological [DOI] 10.1021/acssensors.0c01463 PMC 바로가기 [Article Type] Article
Alkaloids: Therapeutic Potential against Human Coronaviruses알칼로이드: 인간 코로나바이러스에 대한 치료 가능성Article Published on 2020-11-242022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 affinity alkaloid anti-coronavirus activity antiviral activity antiviral drug antiviral drugs binding class Compound Coronavirus-2 Coronaviruses COVID-19 drug host cell Human in silico mechanism MERS-CoV natural products Pathologies pharmacological Potential Receptor-binding domain respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 silico studies Spike protein the receptor-binding domain the SARS-CoV-2 therapeutic treat virus [DOI] 10.3390/molecules25235496 PMC 바로가기 [Article Type] Article
A Non-severe Coronavirus Disease 2019 Patient With Persistently High Interleukin-6 LevelPublic Health Published on 2020-11-162022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Activation baseline changes Chest class Computed tomography COVID-19 COVID-19 patient Cytokine release syndrome elevated HBV infection HCC hepatitis B Hepatocellular carcinoma High-resolution IL-6 immune system Infection Inflammation interleukin 6 (IL-6 Level male marker MONITOR parameter progression respiratory symptom routine severe COVID-19 the patient [DOI] 10.3389/fpubh.2020.584552 PMC 바로가기 [Article Type] Public Health
Sensitivity, Specificity and Predictive Values of Molecular and Serological Tests for COVID-19: A Longitudinal Study in Emergency RoomArticle Published on 2020-09-032022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Accuracy class clinical re-assessment Diagnosis diagnosis of SARS-CoV-2 ELISA Emergency enrolled evaluated Final FIVE highest IgM Infection Latent longitudinal lowest molecular molecular test Negative predictive value NPV Patient PCR positive PPV ranged Rapid diagnostic test RdRP RDT room RT-PCR RT-PCRs SARS-CoV-2 SARS-COV-2 infection sensitivity serological test serology significant difference single gene specificity targets Test utility value was performed [DOI] 10.3390/diagnostics10090669 PMC 바로가기 [Article Type] Article
Identification of Novel Candidate Epitopes on SARS-CoV-2 Proteins for South America: A Review of HLA Frequencies by CountryImmunology Published on 2020-09-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] allele allele frequency approaches binding candidate caused class confirmed case conserved country Coverage COVID-19 dataset death diagnostic tests disease effort epitope experimental evidence filtered Frequency HLA HLA allele frequency HLA allelic HLA frequency identification Immune Epitope Database immunoinformatics include information knowledge literature review MHC NetMHCpan novel NTD pandemic peptide vaccine peptide-based vaccine performed populations predicted presenting Protein RBD region reported responsible resulting review SARS-CoV-2 SARS-CoV-2 protein score selected selection process similar study South South America the Spike thought virus [DOI] 10.3389/fimmu.2020.02008 PMC 바로가기 [Article Type] Immunology
Characterization of Critically Ill COVID-19 Patients at a Brooklyn Safety-Net HospitalInternal Medicine Published on 2020-08-172022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Admission affected analyzed Brooklyn center Characteristics characterization China class Clinical treatment Comorbidities Comorbidity coronavirus correlated country COVID-19 COVID-19 positive patient Critical care Critically ill patient death diabetes Health healthcare hospital Hydroxychloroquine Ill Impact incidence increasingly intensive care Invasive mechanical ventilation median Mortality no significant difference novel coronavirus disease number of comorbidity obesity outcome overall mortality pandemic Patient patient population patients poor prognosis reported Result retrospective SARS-CoV-2 sars-cov-2 (severe acute respiratory syndrome coronavirus -2) selected shown Socioeconomic factor Spread statistically significant difference survival the disease the United State therapy treated vasopressor support Vitamin C were used [DOI] 10.7759/cureus.9809 PMC 바로가기 [Article Type] Internal Medicine
Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis킬러 면역글로불린 유사 수용체와 인간 백혈구 항원 리간드 사이의 전이성 상호작용은 강직성 척추염과 관련이 있습니다Research Article Published on 2020-08-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activating Activation allele Alter Analysis ankylosing spondylitis Antigen Arthritis Autoimmune canonical carriage cause Cell cells class Cohort Combination combinations complement condition conducted contribute contributing to controls damage decrease develop disease dosage Endoplasmic reticulum epistatic interaction epistatic interactions ERAP1 Factor Genetic genetic factors genetic information genotype data Haplotype haplotypes healthy healthy control HLA HLA allele HLA alleles HLA ligand HLA ligands HLA-B human leukocyte antigen human population identify Immune cell immune cells immune system immune-cell Immune-mediated immune-mediated diseases Immunopathogenesis imputation individual Infectious disease inflammatory activity Inflammatory arthritis Inflammatory response inhibitory receptor Inhibitory Receptors instance instances Interaction investigated joint joints killer immunoglobulin-like receptors KIR KIR gene KIR genes KIR-HLA KIR3DL1 KIRs leukocyte Ligand ligands lymphocyte Lymphocytes malignant malignant cells natural killer Pathogenesis pathogenic variant pelvis proinflammatory provide receptor regulated repertoire Research risk shifting specificity spine spondylitis T-cells threshold tissue [DOI] 10.1371/journal.pgen.1008906 PMC 바로가기 [Article Type] Research Article
A Phase 3 Open-label, Randomized, Controlled Study to Evaluate the Efficacy and Safety of Intravenously Administered Ravulizumab Compared with Best Supportive Care in Patients with COVID-19 Severe Pneumonia, Acute Lung Injury, or Acute Respiratory Distress Syndrome: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-07-132022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 24 hour 48 hour Activation acute lung injury acute pneumonia acute respiratory distress syndrome Administered Adult age all-cause mortality Amendment antibodies antibody Antibody test anticipated antiviral therapy approval ARDS assessment assigned baseline Biomarker Blood cardiac disease Care change class Clinical improvement clinical study clinical trial complement Complement inhibitor component Computed tomography concealed Concentration conducted Confirmed Controlled coronary syndrome COVID-19 criteria current Day diagnosis of SARS-CoV-2 dialysis discharge dissemination dose Duration Efficacy element eligibility Endotracheal intubation EU Clinical Trial EudraCT evaluate the effect expected failure female patient Final fraction France Germany greater half-live hospital Hospitalization humanized Hypercoagulable state Immunoglobulin Infection Inflammatory inhibitor initiated intensive care Intubated intubation invasive Invasive mechanical ventilation investigator IVIG Japan Lung injury mechanical ventilation medication monoclonal multicenter Neisseria meningitidis Non-invasive number objective Open-label original outcome oxygen participant Patient patients randomized patients with COVID-19 Period peripheral capillary phase Placebo Pneumonia polymerase chain positive airway pressure presenting progression protocol randomised randomised controlled trial randomization randomization list Randomized randomized controlled study Randomly Ravulizumab receive recruitment registry Remdesivir renal respiratory respiratory distress Respiratory distress syndrome routine clinical care Safety screened Screening secondary Serious Adverse Events serum severe acute respiratory distress syndrome coronavirus 2 Severe acute respiratory syndrome severe COVID-19 severe pneumonia SOFA Spain SpO2 Sponsor stratified Study protocol supportive care survival The United States therapy time Treatment treatment-emergent adverse event Ultomiris United Kingdom ventricular Viral website with COVID-19 X-ray [DOI] 10.1186/s13063-020-04548-z PMC 바로가기 [Article Type] Letter