Immune Phenotyping Based on the Neutrophil-to-Lymphocyte Ratio and IgG Level Predicts Disease Severity and Outcome for Patients With COVID-19Molecular Biosciences Published on 2020-07-032022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome Analysis antibody Antibody Response calculated CD4+ T cell characterized chemiluminescence CLIA Clinical deterioration Clinical outcome complementary coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity Cytokine storm disease disease severity IgG IgG and IgM IgG level IgG levels IgG response IL-10 IL-2 IL-6 immune response Inflammatory cytokine initiated Level Neutrophil-to-lymphocyte ratio NLR non-severe patients occurred outcome outcomes Patient phenotype Phenotypes Phenotyping predict Ratio Respiratory disease robust SARS-CoV-2 sera Severe patient single center Spread stratified Wuhan [DOI] 10.3389/fmolb.2020.00157 PMC 바로가기 [Article Type] Molecular Biosciences
Clinical Use of Short-Course and Low-Dose Corticosteroids in Patients With Non-severe COVID-19 During Pneumonia Progression폐렴 진행 중 심각하지 않은 COVID-19 환자에서 단기 및 저용량 코르티코스테로이드의 임상 사용Public Health Published on 2020-07-032022-09-12 Journal: Frontiers in Public Health [Category] 진단, [키워드] 95%CI Abnormalities accumulated adjusted Administered Admission age analyzed baseline Blood C-reactive protein Chest computed tomography chest radiological clinical clinical condition Clinical deterioration Comorbidities controls coronavirus disease Corticosteroid corticosteroid treatment Corticosteroids COVID-19 COVID-19 patient discharged disease dose evaluated Fever hazard ratio Hospitalization illness onset Immunoglobulin Intervention Intravenous immunoglobulin IQR laboratory parameter Laboratory parameters lactate dehydrogenase low-dose low-dose corticosteroid Lymphocytes median median time Methylprednisolone Patient patients with COVID-19 per day Pneumonia prevent disease progression progressed progression public health radiological radiological evidence reflected retrospective cohort study SARS-CoV-2 severe COVID-19 Sex short-course the patient viral clearance Viral load Virus shedding were given worsening [DOI] 10.3389/fpubh.2020.00355 PMC 바로가기 [Article Type] Public Health
COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role?Case report Published on 2020-07-012022-10-05 Journal: Multiple sclerosis and related disorders [Category] SARS, 유전자 메커니즘, [키워드] B cell B-cell Clinical deterioration Complete Complication coronavirus disease 19 COVID-19 COVID-19 affected patients death depleting discharged disease disease entity Elderly patient Follow-up high risk higher risk Hospitalization Hypothesis immune response Immunosuppressant Immunosuppression immunosuppressive infected patient monoclonal antibody multiple sclerosis occurred overactive Patient patient symptom patients with comorbidity Potential treatment Protective Result Support Symptom tested therapy treated [DOI] 10.1016/j.msard.2020.102120 [Article Type] Case report
Continuous physiological monitoring using wearable technology to inform individual management of infectious diseases, public health and outbreak responsesArticle Published on 2020-07-012022-10-29 Journal: International Journal of Infectious Diseases [Category] Coronavirus, SARS, [키워드] assist Clinical deterioration Clinical use Community Continuous COVID-19 criteria disease Diseases Endemic healthcare highlight hospital implementation IMPROVE Infection Infectious disease information majority management mild illness outbreak Outbreaks Pandemics Patient physiological prevalent privacy public health public health measures response risk severe disease Support Surveillance [DOI] 10.1016/j.ijid.2020.05.086 PMC 바로가기 [Article Type] Article
Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019 The GRECCO-19 Randomized Clinical Trial코로나바이러스 질병 2019로 입원한 환자의 심장 및 염증성 바이오마커와 임상 결과에 대한 콜히친 대 표준 치료의 효과 GRECCO-19 무작위 임상 시험Research Published on 2020-06-242022-08-13 Journal: JAMA Network Open [Category] SARS, 임상, [키워드] 1:1 105 patient 105 patients 95% CI activity acute respiratory syndrome administration Adverse adverse events age all-cause mortality anti-inflammatory action biochemical C-reactive protein cardiac cardiac troponin caution clinical clinical benefit Clinical deterioration clinical end point Clinical outcome clinical outcomes clinical status clinical trial Colchicine colchicine group Complication Concentration control group coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death Deterioration diarrhea dimerized Effect effect of treatment efficacy analysis end point evaluate evaluate the effect evaluated event except for finding followed by global pandemic Greece groups hospital Hospitalized Identifier Importance increase in Infection Inflammatory biomarker intention-to-treat basis interquartile range Loading dose log rank maintenance dose measure mechanical ventilation median no difference no significant difference no significant differences normal activities objective Odds ratio Open-label participant Patient patients patients hospitalized plasma fragment D Point prevention primary end point Randomized randomized clinical trial receipt Registration Relevance respiratory Result safety profile secondary seriousness setting severity significant differences significantly Standard statistically survival survival time symptomatic took place treat Treatment treatment with colchicine Trial registration troponin was performed with COVID-19 [DOI] 10.1001/jamanetworkopen.2020.13136 PMC 바로가기 [Article Type] Research
Early Predictors of Clinical Deterioration in a Cohort of 239 Patients Hospitalized for Covid-19 Infection in Lombardy, ItalyArticle Published on 2020-05-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV Admission age analyzed aspartate assist Blood clinical Clinical deterioration consolidation cough COVID-19 D-dimer death deaths defined described Deterioration elevated Factor feature females ground-glass opacity Hospitalized ICU identify imaging intensive care Italy Laboratory laboratory parameter Lactate lombardy management occurred parameter Patient predictor prognostic receive respiratory rate risk SARS-CoV-2 serum severe acute respiratory syndrome coronavirus 2 Standard deviation suggested supportive care survival Symptom transfer [DOI] 10.3390/jcm9051548 PMC 바로가기 [Article Type] Article
Massive Pulmonary Thromboembolism in Patients with COVID-19; Report of Three CasesCase Report Published on 2020-05-162022-10-27 Journal: Archives of Academic Emergency Medicine [Category] COVID-19, [키워드] Anticoagulant Antithrombotic Characteristics Clinical deterioration clinical presentation Coagulopathy COVID-19 COVID-19 patient disease onset effort Evidence healthcare ICU indicate Infectious disease LMWH massive occurred physician poor prognosis Practitioner Prophylaxis pulmonary Pulmonary embolism report researcher risk severe acute respiratory syndrome coronavirus 2 Severe case the patient Thromboembolic event Thromboembolism thrombolytic therapy Venous Thromboembolism PMC 바로가기 [Article Type] Case Report