Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in SpainPediatrics Published on 2021-01-182022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] Admission Aneurysm children clinical Clinical characteristics Clinical sign collected Confirmed Course COVID-19 criteria diagnosed disease Inflammation Inflammatory Inflammatory marker intensive care Kawasaki disease Kawasaki disease (KD) less leucocyte material multisystem inflammatory syndrome in children (MIS-C) Myocardial dysfunction negative Older overlapping pandemic Patient patients pediatric pediatric inflammatory multisystem syndrome (PIMS-TS) peptide Platelet Prevalence respiratory SARS-CoV-2 Shock significant increase significantly Spain study group Symptom syndrome was collected [DOI] 10.3389/fped.2020.617039 PMC 바로가기 [Article Type] Pediatrics
SARS-CoV-2 in Danish Mink Farms: Course of the Epidemic and a Descriptive Analysis of the Outbreaks in 2020Article Published on 2021-01-122022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] Neovision vision Clinical sign Clinical signs close contact collected Contact COVID-19 COVID-19, increased mortality Denmark disease Environment evaluated examined feed intake global pandemic humans increase in increased mortality Infection median mink Netherland Netherlands number of infected occurred outbreak positive Prevalence rapid increase respiratory symptom SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 prevalence Seroprevalence simple Spread spread to susceptible tested Transmission virus virus transmission [DOI] 10.3390/ani11010164 PMC 바로가기 [Article Type] Article
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets붉은털원숭이, 개코원숭이 및 마모셋 폐의 SARS-CoV-2 급성 감염에 대한 반응Article Published on 2021-01-012022-09-12 Journal: Nature Microbiology [Category] MERS, SARS, 진단, [키워드] acute infection acute respiratory syndrome adaptive age antibody Baboon Bronchoalveolar lavage bystander Cellular immune response Clinical sign clinical trials Computed tomography coronavirus coronavirus disease COVID-19 cytokine production cytokine response distress group humans Immune cell immunohistochemical analyses Infection interferon response lung Lung inflammation Lungs macaque macaques memory Mild moderate Non-human Pathologies progression response rhesus macaques SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific IgG T-cell Therapies titre Vaccine viral infection Viral RNA shedding was increased [DOI] 10.1038/s41564-020-00841-4 PMC 바로가기 [Article Type] Article
Favipiravir Effects on the Control of Clinical Symptoms of Hospitalized COVID-19 Cases: An Experience with Iranian Formulated Dosage FormOriginal Article Published on 2021-01-012022-10-30 Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19, [키워드] Adverse drug reaction adverse effect Antiviral caused clinical Clinical sign clinical trials Combination Control cough COVID-19 disease dose Dyspnea early administration Effect Efficacy and safety evaluate experience Favipiravir FIVE form Hospitalization ICU in both group in both groups infiltration Intervention introduced investigated Iran Laboratory liver enzyme Lopinavir-ritonavir median time Medical Sciences Medicine mortality rate no significant difference not significantly different occurred pandemic Patient patients with COVID-19 peripheral oxygen saturation Pharmacy public health randomized clinical trial recruited reduce Research SARS-CoV-2 SARS-COV-2 infection School Seven significantly Spread Symptom symptoms onset Tablet Tehran the patient time-consuming two groups university X-ray [DOI] 10.22037/ijpr.2021.115510.15401 PMC 바로가기 [Article Type] Original Article
COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency departmentClinical Trial Published on 2021-01-012022-10-05 Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 바이오마커, 임상, [키워드] 95% CI Accuracy adverse outcome Algorithm Analysis Biomarker Biomarkers characteristic Clinical sign Concentration coronavirus disease COVID-19 Endothelial dysfunction evaluated expressed health systems hospital Hospitalized Host identify IL-6 immune activation immune activation. Inflammatory likelihood ratio myeloid cell Outpatient Oxygen requirement pandemic Patient patients with COVID-19 PCR-confirmed COVID-19 patient predicted Predictive presenting prognostic Prospective respiratory rate risk stratification sensitivity soluble Triggering Receptor [DOI] 10.1016/j.jaci.2020.10.001 PMC 바로가기 [Article Type] Clinical Trial
Harnessing Cellular Immunity for Vaccination against Respiratory VirusesReview Published on 2020-12-212022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] activate acute respiratory disease acute respiratory syndrome approach Aside B cell response candidate CD4+ CD8+ T cell Cellular immune response cellular immunity Clinical sign Coronavirus-2 Coronaviruses Critical detrimental Efficacy and safety examined group Health humoral immune response illness immunocompromised individuals immunopathology Infants Infection Influenza long-lasting métapneumovirus Mild morbidity Mortality Nanoparticles neutralizing antibody Patient Pneumonia Protein Research respiratory Respiratory illness respiratory syncytial virus respiratory viral respiratory viral infections respiratory viruses response rhinovirus RNA RNA vaccines robust RSV SARS-CoV-2 severe disease subunits tested These viruses upper respiratory vaccination Vaccine vaccine candidate vaccine candidates viral infection virus Virus-like particle virus-like particles viruses VLPs [DOI] 10.3390/vaccines8040783 PMC 바로가기 [Article Type] Review
Evidence of SARS-CoV-2 Transcriptional Activity in Cardiomyocytes of COVID-19 Patients without Clinical Signs of Cardiac InvolvementArticle Published on 2020-12-182022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] absence activity addition affected alteration analysed assays asymptomatic patients Autopsy autopsy analysis cardiac Cardiomyocytes cell death clinical Clinical sign collected coronavirus COVID-19 COVID-19 patient death Deceased develop digital PCR disease displaying evidence of heart heart tissue immunofluorescence immunohistochemistry Injury investigated Involvement oedema Patient phenotype proportion Respiratory disease Respiratory failure RNA SARS-CoV-2 SARS-CoV-2 spike SIGN subcellular Surveillance transmission electron microscopy viral transcription [DOI] 10.3390/biomedicines8120626 PMC 바로가기 [Article Type] Article
Anakinra treatment in critically ill COVID-19 patients: a prospective cohort studyResearch Published on 2020-12-102022-11-01 Journal: Critical Care [Category] COVID-19, MERS, [키워드] aligned Anakinra Analysis analyzed Aspartate aminotransferase Bilirubin both groups Characteristics circulating cytokine clinical clinical feature Clinical outcome clinical outcomes clinical parameter Clinical sign Concentration control group Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 patient COVID-19 patients creatinine criteria Critical care Critically ill Cytokines decrease develop Diseases Effect effective elevated ferritin Fever groups hyperinflammation Hyperinflammatory hyperinflammatory state ICU ICU admission Immunity inflammatory parameter interleukin-1 receptor antagonist protein investigated mechanical ventilation mechanically ventilated median outcome parameters Patient plasma procalcitonin prospective cohort study Randomized controlled trial receive receptor reducing Result SARS-CoV-2 sensitivity analysis significantly higher standard care subset temperature treated Treatment treatment group was performed White blood cell [DOI] 10.1186/s13054-020-03364-w PMC 바로가기 [Article Type] Research
Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility골든 시리아 햄스터 모델에서 코로나바이러스 질병 2019(COVID-19)의 임상 및 병리학적 징후 시뮬레이션: 질병 발병 및 전염성에 대한 의미Article Published on 2020-12-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료법, [키워드] ACE2 Activation adaptive airway alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal Antibody titer Antibody titers Apoptosis atrophy binding Blood change chemokine clinical Clinical sign Clinical signs Contact convalescent serum coronavirus COVID-19 Diffuse alveolar damage docking expression hamster hamsters histopathological Histopathology immunoprophylaxis initial intestinal involvement with Koch's postulates Laboratory lung Lung pathology lung viral load lymphoid mammal manifestation molecular docking Mortality Mutation Neutralizing antibody titer nonsynonymous option organ Pathogenesis pathological pathology performed physiological proliferative rapid breathing Receptor-binding domain resulting SARS-CoV-2 Serum neutralizing antibody significant decrease Simulation Spike protein spleen suggested the receptor-binding domain tissue tissue repair titer Transmission Treatment vaccination Viral Viral load viral nucleocapsid protein virus virus titer viruses weight loss [DOI] 10.1093/cid/ciaa325 PMC 바로가기 [Article Type] Article
Comparative analysis of COVID-19 guidelines from six countries: a qualitative study on the US, China, South Korea, the UK, Brazil, and HaitiResearch Article Published on 2020-12-032022-10-28 Journal: BMC Public Health [Category] COVID-19, MERS, [키워드] affecting Analysis analyzed Brazil China Clinical sign Community Comparative analysis Comparisons concern confirmed case Contact tracing coronavirus country COVID-19 COVID-19 cases COVID-19 guideline COVID-19 pandemic criteria Critical decrease dependent on document dramatic increase Emergency exploratory Factor General population Government Government guidelines Guidance Haiti healthcare Healthcare professional healthcare professionals Healthcare system Healthcare systems highlight identify initial National outbreak Outbreak COVID-19 pandemic Prevent proportions PROTECT Public resource Result sick similarity social distancing South Korea Spread spread of COVID-19 Stage supplementary material symptoms of COVID-19 the WHO Threats worldwide crisis [DOI] 10.1186/s12889-020-09924-7 PMC 바로가기 [Article Type] Research Article