iCOVID: interpretable deep learning framework for early recovery-time prediction of COVID-19 patientsArticle Published on 2021-08-162022-10-04 Journal: NPJ Digital Medicine [Category] 바이오마커, 치료법, 치료제, [키워드] Admission affecting age average Biomarker collected Comorbidities Concordance COVID-19 patient COVID-19 patients deep learning effective experiment feature heterogeneous hospital information machine learning mechanism Mortality MOST Patient predict reveal severity Symptoms Treatment viral infection Wuhan, China [DOI] 10.1038/s41746-021-00496-3 PMC 바로가기 [Article Type] Article
Impact of Full Vaccination with mRNA BNT162b2 on SARS-CoV-2 Infection: Genomic and Subgenomic Viral RNAs Detection in Nasopharyngeal Swab and Saliva of Health Care WorkersArticle Published on 2021-08-142022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] analysed Analysis Asymptomatic B.1.1.7 variant baseline BNT162b2 Concordance coronavirus Course cumulative detection droplet digital PCR eight expression Frequency HCW HCWs Health care worker hospitals identify Impact incidence individual individuals infected individuals Infection investigated majority MONITOR mRNA BNT162b2 Mutation N501Y NPs performed positive provided real time real time RT-PCR real-time RT-PCR receiving resulting RNA RT-PCR Saliva saliva specimen SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 surveillance specimens subgenomic subjects symptomatic symptomatic cases tested Transmission vaccination Vaccine vaccinee variants Viral load Viral mutations Viral RNA was measured worker [DOI] 10.3390/microorganisms9081738 PMC 바로가기 [Article Type] Article
Mass Screening of Asymptomatic Persons for Severe Acute Respiratory Syndrome Coronavirus 2 Using Saliva타액을 이용한 중증급성호흡기증후군 코로나바이러스 2에 대한 무증상자 집단 스크리닝Comment Published on 2021-08-022022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Asymptomatic Asymptomatic carriers Chain Reaction Cohort Concordance conducted Containment coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 correlated COVID-19 credible interval detection disease global pandemic individual individuals LAMP mass Mass screening Nasopharyngeal swab NPs nucleic acid nucleic acid amplification nucleic acid amplification testing outbreak PCR Person polymerase chain polymerase chain reaction Polymerase chain reaction testing positive Prevalence Probability quarantine respiratory Saliva saliva samples saliva specimen saliva specimens saliva test SARS-CoV-2 Screening sensitivities sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus Specificities specificity specimen Transmission utility Viral load virus [DOI] 10.1093/cid/ciaa1388 PMC 바로가기 [Article Type] Comment
MALDI-ToF protein profiling as a potential rapid diagnostic platform for COVID-19Research article Published on 2021-08-012022-10-05 Journal: Journal of Mass Spectrometry and Advances in the Clinical Lab [Category] 바이오마커, 변종, 진단, [키워드] liquid chromatography mass spectrometry ACE2angiotensin-converting enzyme 2 Analysis analyzed angiotensin-converting enzyme 2 area under the curve Asymptomatic AUCarea under the curve Biomarker Cohort Concordance controls Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 testing COVID-19coronavirus disease 2019 CT cycle threshold demonstrated develop diagnostic Diagnostic method dithiothreitol DTTdithiothreitol E Proteinenvelope protein Emergency use authorization envelope protein EUAemergency use authorization FDAFood and Drug Administration Food and Drug Administration human donor human serum IgAimmunoglobulin A IgGimmunoglobulin G IgMimmunoglobulin M immunoglobulin A Immunoglobulin G immunoglobulin M immunoglobulins inactivated LC-MS limit of detection limitation LoDlimit of detection M Proteinmembrane protein MALDI-ToF MSmatrix-assisted laser desorption/ionization-time of flight mass spectrometry matrix-assisted laser desorption/ionization-time of flight mass spectrometry membrane protein N Proteinnucleocapsid protein nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs Non-invasive NPnasopharyngeal nucleocapsid protein pilot study platform positive individuals Protein proteome RBDReceptor Binding Domain receiver operating characteristic Receptor binding domain Reverse transcriptase quantitative polymerase chain reaction Ribonucleic acid RNARibonucleic acid ROCreceiver operating characteristic RT-qPCR S Proteinspike protein Saliva SARS-CoV-2 SARS-CoV-2 strains SARS-CoV-2 virus SARS-CoV-2severe acute respiratory syndrome coronavirus 2 sensitivity severe acute respiratory syndrome coronavirus 2 specificity specimen Spike protein VEPviral envelope protein viral envelope protein WHOWorld Health Organization with COVID-19 World Health Organization [DOI] 10.1016/j.jmsacl.2021.09.001 [Article Type] Research article
A novel strategy for SARS-CoV-2 mass screening with quantitative antigen testing of saliva: a diagnostic accuracy study타액의 정량적 항원 검사를 통한 SARS-CoV-2 대량 스크리닝을 위한 새로운 전략: 진단 정확도 연구Article Published on 2021-08-012022-09-11 Journal: The Lancet. Microbe [Category] SARS, 치료기술, [키워드] Accuracy Antigen Asymptomatic clinically close contact Community community health Concentration concentrations Concordance COVID-19 credible interval CrI Cutoff cutoff value detect develop diagnostic Diagnostic accuracy enrolled enzyme enzyme immunoassay followed by Fujirebio Health hospitalised patient Hospitalised patients immunoassay IMPROVE initial International Japan Japanese less Local mass Mass screening Ministry of Health Nasopharyngeal swab negativity NPs participant positive Prevalence Probability proportion proportions provide quantified Quantitative Quantitative RT-PCR Result RT-PCR RT-qPCR Saliva saliva samples salivary SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 nucleoprotein screening strategy sensitivity specificity Test tested threshold Tokyo utility was obtained Welfare [DOI] 10.1016/S2666-5247(21)00092-6 PMC 바로가기 [Article Type] Article
Expanding access to SARS-CoV-2 IgG and IgM serologic testing using fingerstick whole blood, plasma, and rapid lateral flow assays핑거스틱 전혈, 혈장 및 신속한 측면 흐름 분석을 사용하여 SARS-CoV-2 IgG 및 IgM 혈청학적 검사에 대한 접근 확대Article Published on 2021-08-012022-09-12 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, [키워드] Abbott antibodies Asymptomatic automated Blood can be used capillary blood collected Concordance controls convalescent plasma DBS sample DBS samples Diagnosis disease donors Dried blood spots Efficacy examined expand fingerstick IgM lateral flow linearity Microtainer Patient PCR-confirmed COVID-19 plasma plasma sample point-of-care positive R 2 Rapid rapid diagnostics reproducibility SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 testing serologic serologic testing serology testing stability Symptom Vaccine venous Whole blood whole blood sample [DOI] 10.1016/j.jcv.2021.104855 PMC 바로가기 [Article Type] Article
Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodiesSARS-COV-2 스파이크 단백질 ELISA 및 항체 검출을위한 Abbott Architect SARS-COV-2 IgG Nucleocapsid 단백질 분석의 비교Comparative Study Published on 2021-07-292022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Abbott antibody antigens Architect Concordance detect ELISA indicated nucleocapsid nucleocapsid protein SARS-CoV-2 SARS-CoV-2 IgG serologic serologic assays Spike protein subtype the SARS-CoV-2 [DOI] 10.1371/journal.pone.0255208 PMC 바로가기 [Article Type] Comparative Study
A surrogate virus neutralization test to quantify antibody-mediated inhibition of SARS-CoV-2 in finger stick dried blood spot samples손가락 스틱 건조 혈액 반점 샘플에서 SARS-COV-2의 항체-매개 억제를 정량화하기위한 대리 바이러스 중화 시험Article Published on 2021-07-282022-09-01 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, [키워드] ACE2 agreement Analysis angiotensin antibodies Antigen Blood blood collection can be used Coefficient of variation collected Concordance control sample convalescent COVID-19 COVID-19 sample DBS sample DBS samples dilution series dilution sery effective engage enzyme expand expected Filter Paper General population host cells human Angiotensin-converting enzyme Immunity immunoassay Immunological techniques incubated indicated Infection Interaction Large-scale testing Live virus marker measure neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody PCR phase plate populations positive Precision Prevent produced protective immunity provide receptor reliability Sample SARS-CoV-2 serum serum samples solid phase Spike protein stick surrogate Variation venous venous blood virus neutralization test Whole blood [DOI] 10.1038/s41598-021-94653-z PMC 바로가기 [Article Type] Article
Predicting clinical outcomes among hospitalized COVID-19 patients using both local and published modelsResearch Published on 2021-07-242022-10-27 Journal: BMC Medical Informatics and Decision Making [Category] COVID-19, [키워드] AUC average China Chinese patients clinical decision Clinical outcome clinician Cohort Concordance COVID-19 evaluated feature Generalizability healthcare help Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients ICU admission implementation information Inpatient lab literature review Local Model generalizability Mortality operator organization outcome pandemic Patient patients performed predict predicted prediction produced provided ranged Result searched selected Seven statistical model Support tested treating COVID-19 patient variables with COVID-19 [DOI] 10.1186/s12911-021-01576-w PMC 바로가기 [Article Type] Research
Predicting clinical outcomes among hospitalized COVID-19 patients using both local and published modelsResearch Published on 2021-07-242022-10-27 Journal: BMC Medical Informatics and Decision Making [Category] Coronavirus, COVID-19, SARS, [키워드] AUC average China Chinese patients clinical decision Clinical outcome clinician Cohort Concordance COVID-19 evaluated feature Generalizability healthcare help Hospitalization hospitalized COVID-19 patient hospitalized COVID-19 patients ICU admission implementation information Inpatient lab literature review Local Model generalizability Mortality operator organization outcome pandemic Patient patients performed predict predicted prediction produced provided ranged Result searched selected Seven statistical model Support tested treating COVID-19 patient variables with COVID-19 [DOI] 10.1186/s12911-021-01576-w PMC 바로가기 [Article Type] Research