Effects of the COVID-19 Pandemic on Job Activity, Dietary Behaviours and Physical Activity Habits of University Population of Naples, Federico II-ItalyCOVID-19 팬데믹이 나폴리 대학 인구의 직업 활동, 식습관 및 신체 활동 습관에 미치는 영향, Federico II-ItalyArticle Published on 2021-02-052022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, 변종, [키워드] activity affected age average average age behavioural changes conducted COVID 19 COVID-19 CoVs cross-sectional cross-sectional study dietary eating habits Effect female females Gender global health Government habit Health heterogeneous Isolation Italian Italian government Italy job male men Mild mild to moderate mild to moderate illness moderate Naple Naples pandemic participant physical physical activity physical activity habit physical activity habits Population Psychological quarantine respiratory respiratory virus respiratory viruses socio-demographic Spread survey and university population university variant virus viruses [DOI] 10.3390/ijerph18041502 PMC 바로가기 [Article Type] Article
Molecular recognition in the infection, replication, and transmission of COVID-19-causing SARS-CoV-2: an emerging interface of infectious disease, biological chemistry, and nanoscience Reviews Published on 2021-02-052022-10-05 Journal: NPG Asia Materials [Category] 변종, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive addition angiotensin-converting enzyme 2 Antiviral binding coronavirus coronavirus disease CoV CoV infection COVID-19 CoVs develop epithelial cell form function Genome glycans Host host cell Human IFN IFNs immune response Immunity immunology infected with SARS-CoV-2 Infection Infectious disease interferon involved macaque mechanism Medicine mutated Mutation N-acetylneuraminic acid nuclear outbreak pandemic Pandemics pathway physician platform progeny virion protease Protein receptor Replication researchers RNA SARS-CoV SARS-CoV-2 secretion serine 2 severity SGP sialic acid specificity spike glycoprotein stimulate Structure Symptom the cytokine storm the SARS-CoV-2 Toll-like receptor Transcription transmembrane Transmission Vaccine virus Wuhan [DOI] 10.1038/s41427-020-00275-8 [Article Type] Reviews
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene ExpressionReview Published on 2021-02-022022-10-31 Journal: Cells [Category] COVID-19, MERS, [키워드] activity acute respiratory syndrome Amino acid antiviral responses biological function cell interaction cellular cleavage contribute Control Coronaviruses CoVs disrupt endonucleolytic cleavage evade function Gene Expression genomes highly pathogenic Host host gene expression host gene expression suppression host mRNA human coronavirus identity involved mechanism MERS-CoV Middle East mRNA mRNA degradation nonstructural protein 1 nsp1 pathogenic SARS-CoV SARS-CoV-2 suppresse syndrome translation translational suppression viral mRNA viral pathogenicity Viral protein viral replication virulence virulence factor virus virus pathogenesis [DOI] 10.3390/cells10020300 PMC 바로가기 [Article Type] Review
Structure of Nonstructural Protein 1 from SARS-CoV-2SARS-CoV-2의 비구조 단백질 1의 구조Article Published on 2021-01-282022-09-11 Journal: Journal of Virology [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter Antiviral antiviral therapy carboxyl causative agent cellular city clone conformation coronavirus Coronavirus replication CoV COVID-19 COVID-19 pandemic CoVs Critical crystal structure cultured cells Deletion effective vaccine Effective vaccines element facilitate Factor Features flexible function Health high-resolution crystal structure Host host cell infecting inhibit innate immune response life cycle live-attenuated vaccines mechanism molecular mRNA degradation Mutation nonstructural protein 1 Novel coronavirus novel coronaviruses nsp1 Occurrence Pneumonia prevented promote Protein public health recruited respiratory Respiratory illness reveal SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 NSP1 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe respiratory illness shown Structure structure-function Support target therapeutic option translation turn underlie Vaccine design Vaccine development Viral viral life cycle virus virus infection Wuhan Wuhan, China X-ray X-ray crystallography [DOI] 10.1128/JVI.02019-20 PMC 바로가기 [Article Type] Article
The emerging SARS-CoV, MERS-CoV, and SARS-CoV-2: An insight into the viruses zoonotic aspectsReview Article Published on 2021-01-232022-10-29 Journal: Veterinary World [Category] COVID-19, [키워드] acute respiratory syndrome Angiotensin-converting enzyme bats caused CD26 coronavirus coronavirus disease Coronavirus disease-19 CoV COVID COVID-19 CoVs deaths domain DPP4 Health identity MERS-CoV Middle East new strain pandemic Pneumonia produced provoking receptor recovered patient reservoirs respiratory infection RNA viruses SARS-CoV SARS-CoV-2 severe respiratory disease Spread the SARS-CoV-2 virus wild animals zoonotic zoonotic disease [DOI] 10.14202/vetworld.2021.190-199 PMC 바로가기 [Article Type] Review Article
Exercise, Immune System, Nutrition, Respiratory and Cardiovascular Diseases during COVID-19: A Complex CombinationReview Published on 2021-01-212022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] absence acute respiratory syndrome cardiovascular cardiovascular diseases Cardiovascular disorders coronavirus CoV CoVs defend disease evade exercise function Health Host humans immune immune response immune system infect Interaction nutrition physical activity Physical exercise provide replicate respiratory respiratory infection RNA virus System [DOI] 10.3390/ijerph18030904 PMC 바로가기 [Article Type] Review
Horizontal gene transfer and recombination analysis of SARS-CoV-2 genes helps discover its close relatives and shed light on its originSARS-CoV-2 유전자의 수평적 유전자 전달 및 재조합 분석은 가까운 친척을 발견하고 기원을 밝히는 데 도움이 됩니다.Research Article Published on 2021-01-212022-09-10 Journal: BMC Ecology and Evolution [Category] MERS, 유전자 메커니즘, [키워드] Analysis ancestor ancestors bat bats Cluster Clustering Consensus tree coronavirus coronavirus strain CoV CoVs domain event Evolution Evolution of SARS-CoV-2 Gene evolution Genes Genome Guangdong help horizontal gene Horizontal gene transfer horseshoe bat Host hosts Human human coronavirus intermediate host intermediate hosts mechanism MERS-CoV ORF1 ORF10 ORF1ab ORF3a ORF6 ORF7a ORF7b ORF8 organism outbreak pangolin Phylogenetic network Phylogeny Previous studies previous study RaTG13 Receptor binding Recombination recombination event Region Result reveal SARS-CoV SARS-CoV-2 SARS-CoV-2 gene SARS-CoV-2 genome SARS-CoV-2 pandemic Spike protein statistically significant strain Strains suggested the SARS-CoV-2 genome the spike protein transfer virus [DOI] 10.1186/s12862-020-01732-2 PMC 바로가기 [Article Type] Research Article
The coronavirus proofreading exoribonuclease mediates extensive viral recombination코로나바이러스 교정 엑소리보뉴클레아제는 광범위한 바이러스 재조합을 매개합니다Research Article Published on 2021-01-192022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, MERS, 유전자 메커니즘, 진단, 치료제, [키워드] attenuation conserved coronavirus coronavirus exoribonuclease coronavirus proofreading exoribonuclease Coronavirus replication CoV CoV polymerase CoV recombination CoV replication CoVs Critical Culture defective viral genome determinant determinants Diversity DVGs ExoN Exoribonuclease Frequency generate highlight immune evasion implicated inactivation Infection inhibitor inhibitors loci maintain mechanism MERS MERS-CoV MHV MHV nsp14-ExoN molecular mechanism molecular mechanisms murine hepatitis virus novel coronaviruses nsp14 nsp14-ExoN nucleoside Nucleoside analogues outbreak pandemic Population Prevent produced Recombination recombination frequency recombination junctions Replication required responsible RNA RNA proofreading exoribonuclease RNA recombination RNA synthesis SARS-CoV-2 sequence sequences similarity sub-genomic mRNA sub-genomic mRNAs These data Viral viral recombination virulence while zoonotic CoVs [DOI] 10.1371/journal.ppat.1009226 PMC 바로가기 [Article Type] Research Article
The histo-blood group antigens of the host cell may determine the binding of different viruses such as SARS-CoV-2숙주 세포의 조직 혈액 그룹 항원은 SARS-CoV-2와 같은 다른 바이러스의 결합을 결정할 수 있습니다Review Published on 2021-01-182022-09-10 Journal: Future Microbiology [Category] 유전자 메커니즘, [키워드] adhesion antigens binding caused coronavirus CoVs death dependent on determine family group antigens HBGAs histo-blood group antigen host cell host’s cell host’s cells human CoV human host individual infection mechanism mechanism occur organs S glycoprotein SARS-CoV-2 susceptibility the SARS-CoV-2 virus viruses Wuhan Wuhan, China [DOI] 10.2217/fmb-2020-0158 PMC 바로가기 [Article Type] Review
Structure of the multiple functional domains from coronavirus nonstructural protein 3Coronaviruses Published on 2021-01-172022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, [키워드] active site activity Antiviral asymmetric unit catalytic domain cleavage site cleave complex conducted conserved coronavirus CoV CoVs domain drug design enzyme activity exhibit fluorescent functional homodimer Host infect Interaction macro Macro domain mimicking monomer motif Multiple functional domains mutant Neurological diseases nonstructural protein 3 Nsp3 pandemic Papain-like protease papain-like protein pathogen peptide PLPro protease protein 3 replication mechanism significantly stability stimulated Structure substrate substrates subunit targets ubiquitin-like domain variety [DOI] 10.1080/22221751.2020.1865840 PMC 바로가기 [Article Type] Coronaviruses