Cross-reactive antibodies after SARS-CoV-2 infection and vaccinationSARS-CoV-2 감염 및 예방접종 후 교차 반응 항체Research Article Published on 2021-11-232022-10-31 Journal: eLife [Category] COVID-19, SARS, 파상풍, [키워드] addition antibodies antibodies binding antibody convalescent sera coronavirus COVID-19 cross-reactive antibody cross-reactivity current Efficacy feasibility Guidance HCoV healthy donors Human human coronavirus humans increase in investigated macaque MERS-CoV Novel coronavirus Other Outbreaks PROTECT protective vaccines Protein response S protein SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine specificity Support the S protein vaccination Vaccine variant [DOI] 10.7554/eLife.70330 PMC 바로가기 [Article Type] Research Article
Detection of cross-reactive immunoglobulin A against the severe acute respiratory syndrome-coronavirus-2 spike 1 subunit in saliva중증 급성 호흡기 증후군-코로나 바이러스 -2 스파이크에 대한 교차 반응성 면역 글로불린 A의 검출 1 타액의 서브 유닛Research Article Published on 2021-11-232022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 진단, 치료기술, [키워드] age analyzed angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 binding Biotin blood sample Blood samples breast milk Chain Reaction correlated cross-react cross-reaction cross-reactive cross-reactivity dental dentist dentists detection determined by enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay help IgG and IgM Immunity immunochromatography Immunoglobulin immunoglobulin A individual Infection involved men mucosal surfaces Mucus Patient patients PCR PCR-negative polymerase chain polymerase chain reaction Prevent proportion Protein provide purified reaction receptor Receptor-binding domain reported Saliva saliva samples SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein secretory immunoglobulin A SIgA significantly lower Spike protein subunit suppress the receptor-binding domain university virus was determined women [DOI] 10.1371/journal.pone.0249979 PMC 바로가기 [Article Type] Research Article
Optimization and Clinical Validation of Colorimetric Reverse Transcription Loop-Mediated Isothermal Amplification, a Fast, Highly Sensitive and Specific COVID-19 Molecular Diagnostic Tool That Is Robust to Detect SARS-CoV-2 Variants of ConcernMicrobiology Published on 2021-11-182022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome alternative method B.1.617.2 Brazil clinical collected concern confidence interval coronavirus coronavirus disease country COVID-19 COVID-19 testing cross-reactivity demonstrated detect diagnostic diagnostic test effort equipment genomic gold standard isothermal amplification limit of detection meet molecular molecular test N genes Nasopharyngeal swab optimization P.1 P.2 pandemic Pandemics performed point-of-care polymerase chain reaction respiratory virus reverse transcription RNA RT-LAMP RT-qPCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 RNA detection SARS-CoV-2 variant sensitive sensitivity Specific specificity Transmission Typical validation variant variants of interest Viral transport medium virus widespread [DOI] 10.3389/fmicb.2021.713713 PMC 바로가기 [Article Type] Microbiology
Detection of Antibodies Against the SARS-CoV-2 Spike Protein and Analysis of the Peripheral Blood Mononuclear Cell Transcriptomic Profile, 15 Years After Recovery From SARSSARS-CoV-2 스파이크 단백질에 대한 항체 검출 및 SARS 회복 15년 후의 말초혈액 단핵세포 전사체 프로파일 분석Cellular and Infection Microbiology Published on 2021-11-182022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Against antibodies antibody binding cellular entry cellular immunity chemiluminescence chemokine clinical manifestations collected conducted convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity cytokine detection elicit epitope Epitopes exhibited expressed Genes heatmap homology immune immune cross-reactivity Immune status Immunity immunoassay in vitro inhibit interferon gamma microsphere mononuclear cell mRNA mRNAs pandemic patients with COVID-19 patients with SARS PBMC PBMCs peptide peptide epitope peripheral Peripheral blood Peripheral blood mononuclear cells Post-infection profile protein sequences Research respiratory responses SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein serum serum antibodies severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signal transduction significantly spike Spike protein stimulated the SARS-CoV-2 transcriptomic profile was obtained were used Year [DOI] 10.3389/fcimb.2021.768993 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
COVID-19 in Africa: preexisting immunity and HIVEditorial Comments Published on 2021-11-152022-10-28 Journal: AIDS (London, England) [Category] COVID-19, MERS, SARS, [키워드] Co-infections COVID-19 cross-reactivity HIV Immunity Preexisting immunity SARS-CoV-2 [DOI] 10.1097/QAD.0000000000003079 PMC 바로가기 [Article Type] Editorial Comments
Severe acute respiratory syndrome coronavirus-2 antibody prevalence in people with and without HIV in rural Western Kenya, January to March 20202020년 1월부터 3월까지 서부 케냐 시골 지역에서 HIV가 있거나 없는 사람들의 중증 급성 호흡기 증후군 코로나바이러스-2 항체 유병률Article Published on 2021-11-152022-09-11 Journal: AIDS (London, England) [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome antibody asymptomatic infection asymptomatic infections Coronavirus-2 cough COVID-19 case cross-reactivity detectable HIV Kenya participant Prevalence reported SARS-CoV-2 antibodies SARS-CoV-2 antibody Symptoms tested [DOI] 10.1097/QAD.0000000000003054 PMC 바로가기 [Article Type] Article
Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein키메라 스파이크 단백질을 발현하는 VSV 벡터에 의해 유발되는 SARS-CoV-2에 대한 보호 면역 강화Article Published on 2021-11-102022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 administration Antigen cellular receptor Chimera chimeric coronavirus COVID-19 vaccines cross-neutralizing cross-reactivity dose elicit elicited enhanced expressing Genetic glycoprotein hACE2 Human human ACE2 humoral immune response immunization immunized immunized mice indicate intramuscular intranasal lesion Lungs macaque macaques mice Mouse models NAb nAb response NAbs neutralizing antibody protective immunity RBD receiving Receptor binding domain replacing rVSV-SARS-CoV-2 S protein Safe SARS-CoV SARS-CoV S SARS-CoV-2 SARS-CoV-2 RBD sera serum significantly significantly increased similarity single dose spike Spike protein spikes the S protein the SARS-CoV-2 titers transplantation Vaccines viruses VSV wild-type [DOI] 10.1038/s41392-021-00797-9 PMC 바로가기 [Article Type] Article
Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native, B.1.351, B.1.617.2, and P.1 SARS-CoV-2 spike proteins근원이없는 COVID-19 긍정적 인 개체로부터의 항체의 교차 반응성, B.1.351, B.1.617.2 및 p.1 SARS-COV-2 스파이크 단백질Article Published on 2021-11-082022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE-2 ACE-2 receptor Adults affinity analyzed antibodies antibody antibody level antibody levels B.1.351 B.1.617.1 B.1.617.2 Beta BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 collected COVID-19 cross-reactivity Delta ectodomain Effectiveness elicited enrolled Evidence evidence of except for Gamma humoral Humoral response implication individual individuals infected with SARS-CoV-2 inhibited Interaction interactions nCoV neutralization Optical sensors P.1 P.1 variant pandemic PCR-confirmed positive individual Proteins relative SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein Spike proteins SPR Spread sustained the spike protein vaccinated individual vaccinated individuals vaccination variant spike VoC VOCs [DOI] 10.1038/s41598-021-00844-z PMC 바로가기 [Article Type] Article
False-positive HIV in a patient with SARS-CoV-2 infection; a case reportCase Report Published on 2021-11-062022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] antibody antibody cross-reactivity Case report Corona coronavirus COVID-19 COVID-19 patient COVID-19 vaccination cross-reactivity Diagnosis Epstein Barr virus False positive False-positive false-positive result female HIV Human immunodeficiency virus immunoassay Infection influenza vaccination interfere Laboratory MERS-CoV Mild symptom Patient patient with SARS-CoV-2 PCR PCR testing positive problem Protein reported required RNA SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein screening test screening tests Sensitivity and specificity similarity Spike protein Supportive treatment the immunoassay the spike protein Thyroid thyroidectomy turn virus viruses was performed yielding Zika [DOI] 10.1016/j.amsu.2021.103027 PMC 바로가기 [Article Type] Case Report
146. Intact Sense of Taste and Smell During COVID-19 Infection Is Associated with Absence of of SARS-CoV-2 Spike Protein Antibody Responses within 3 Months of Symptomatic IllnessOral Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] age Alpha Anosmia/ageusia antibody Antigen Asian association baseline beta coronavirus black breadth characterized clinical factors clinical phenotypes clinically Cohort collected company Control cough COVID-19 COVID-19 infection COVID-19 symptoms cross-reactivity demographics demonstrated description difference disease disease severity employee enrolled Epitopes female Fever figure group had no health system heterogeneous identify illness immune response Immunity include Intact Josh less Lilly list magnitude mild illness mild infection Month mRNA vaccination participant Patient patient population PCR-confirmed plasma sample platform Post-infection predict Prevent profile Protective Protein questionnaire Re-infection recovered patients reported response responses Result Robert SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein sense sense of smell significantly Smell spike Spike protein Stephanie survivor symptom onset symptomatic Symptoms Taste tested the antibody response white [DOI] 10.1093/ofid/ofab466.146 PMC 바로가기 [Article Type] Oral Abstracts