Deleterious
[용어속성] Term
Gut Microbiota Status in COVID-19: An Unrecognized Player?
Cellular and Infection Microbiology
Published on
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,
Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS,
[키워드] Affect
alteration
Bacterial
Cardiopulmonary
cause
characterized
clinical condition
clinical implication
Comorbidities
Comorbidity
complex
complications
Consequences
Course
COVID-19
Deleterious
develop
example
fatality
gut microbiota
gut-lung axis
Health status
healthy
influence
influenza A
Interaction
intestinal
majority
Microbiome
microbiota
microbiota manipulating
microbiota-virus interactions
Particle
pathogenic mechanism
pharmacological
polypharmacy
preventive therapeutic strategies
progression
reduce
regimen
Resilience
risk
risk factor
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV2 infection
severity
status
subject
surface molecule
susceptibility
target
the SARS-CoV-2 virus
Treatment
understanding
variety
Vascular
viral infections
virulence
viruses
[DOI] 10.3389/fcimb.2020.576551 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
[DOI] 10.3389/fcimb.2020.576551 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Nations with high smoking rate have low SARS-CoV-2 infection and low COVID-19 mortality rate
Observational Study
[키워드] adjust
applied
confounding factors
country
COVID-19
COVID-19 disease
COVID-19 mortality
death
Deleterious
epidemiological
expressed
Factors
intensive care
interquartile range
male
manuscript
mechanism of action
median
nation
patients
Prevalence
Protective
Research
Result
SARS-COV-2 infection
smoker
smoking
three group
[DOI] 10.23750/abm.v91i4.10721 PMC 바로가기 [Article Type] Observational Study
[DOI] 10.23750/abm.v91i4.10721 PMC 바로가기 [Article Type] Observational Study
COVID-19: How to Reduce Some Environmental and Social Impacts?
Viewpoint
[키워드] Care
COVID-19
COVID-19 pandemic
Deleterious
generate
Health
help
impacts
Perspective
PPE
public health
Support
[DOI] 10.5334/aogh.3104 PMC 바로가기 [Article Type] Viewpoint
[DOI] 10.5334/aogh.3104 PMC 바로가기 [Article Type] Viewpoint
Association of cardiac biomarkers and comorbidities with increased mortality, severity, and cardiac injury in COVID-19 patients: A meta-regression and decision tree analysis
COVID-19 환자의 사망률, 중증도 및 심장 손상이 증가한 심장 바이오마커 및 동반 질환의 연관성: 메타 회귀 및 의사 결정 트리 분석
Meta-Analysis
[키워드] 95% CI
95% confidence interval
advanced age
adverse outcome
adverse outcomes
Analysis
applied
aspartate
Aspartate aminotransferase
assessment
association
AST
best
Biomarker
cardiac injury
cardiac marker
Cardiac markers
cardiac troponin
cardiovascular disease
cardiovascular diseases
cardiovascular system
characteristic
CIs
clinical feature
Comorbidity
coronavirus
coronavirus disease
coronavirus disease-2019
COVID-19
COVID-19 severity
Cutoff
Decision tree
Deleterious
develop
elevated
highest
IMPROVE
increased mortality
Injury
Laboratory
lead
Meta-analysis
meta-regression
Mortality
mortality rate
myocardial injury
Odds ratio
outcome
outcomes
Patient
patients with COVID-19
predict
prognostic
receiver operating characteristic
risk
SARS-CoV-2
severity
SMD
standardized mean difference
therapeutic approaches
threshold
troponin I
[DOI] 10.1002/jmv.26166 PMC 바로가기 [Article Type] Meta-Analysis
[DOI] 10.1002/jmv.26166 PMC 바로가기 [Article Type] Meta-Analysis
Small Resistance Artery Disease and ACE2 in Hypertension: A New Paradigm in the Context of COVID-19
Cardiovascular Medicine
[키워드] ACE2
alteration
angiotensin-converting enzyme 2
Arterial hypertension
Artery
binding
blood flow
cardiovascular
catalytic domain
cause
cell entry
clinical study
Context
contribute
COVID-19
death
Deleterious
diagnosed with COVID-19
disease
Endothelial dysfunction
event
events
Evidence
feature
Hyperactivation
Inflammation
Inflammatory
knowledge
Local
morbidity and mortality
New
Occurrence
organs
oxidative
oxidative and inflammatory stress
oxidative stress
PAH
paradigm
pathology
pathophysiology
pathway
Patient
prevalent
primary arterial hypertension
Protein
RAS
regulate
renin–angiotensin–aldosterone system
reported
resistance
responsible
risk
SARS-CoV2
small resistance arteries
small vessel
Stress
thrombosis
tissue
Vascular
virus
[DOI] 10.3389/fcvm.2020.588692 PMC 바로가기 [Article Type] Cardiovascular Medicine
[DOI] 10.3389/fcvm.2020.588692 PMC 바로가기 [Article Type] Cardiovascular Medicine
Immunomodulatory Therapies for COVID-19 in Solid Organ Transplant Recipients
COVID19 and Transplantation (R Avery, Section Editor)
[키워드] absence
administration
Anecdotal
anti-IL-1
anti-IL-6
appear
bacterial superinfection
baseline
benefit
canakinumab
Case series
characterized
clinical benefit
clinical experience
cohort study
Colchicine
control group
coronavirus disease
Corticosteroid
COVID-19
CRS
cytokine
Cytokine release syndrome
Deleterious
Efficacy and safety
Evidence
finding
heterogeneity
Hyperinflammatory
immunomodulation
immunomodulatory therapy
Immunosuppression
inhibitor
Interpretation
kidney
lack
limit
management
monoclonal
NLRP3 inflammasome
non-transplant patients
observational study
Patient
pleiotropic
Pneumonia
randomized clinical trial
RCT
recent
recipient
reported
review
Safe
shown
Solid
solid organ transplantation
SOT
survival
therapeutic strategy
tissue damage
Tocilizumab
tocilizumab therapy
Transplant
with COVID-19
[DOI] 10.1007/s40472-020-00306-x PMC 바로가기 [Article Type] COVID19 and Transplantation (R Avery, Section Editor)
[DOI] 10.1007/s40472-020-00306-x PMC 바로가기 [Article Type] COVID19 and Transplantation (R Avery, Section Editor)
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
생명을 위협하는 COVID-19 환자에서 I형 IFN 면역의 선천적 오류
Research Article
[키워드] a minor
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
administration
Affect
affecting
age
amplification
amplification pathway
Asymptomatic
autoantibodies
autoantibody
autoantibody system
autosomal-dominant
autosomal-recessive
Beck
biochemically
BOLD
candidate gene approach
caused
cellular
clinical
Clinical course
Clinical outcome
clinical variability
complete penetrance
complex
component
components
core gene
core genes
coronavirus
coronavirus disease
Coronavirus disease 2019
Course
COVID
COVID Human Genetic Effort
COVID-19
COVID-19 patient
COVID-19 pneumonia
Critical
Critical disease
cytokine
Cytokines
damage
dampen
deficiencies
deficiency
defined
Deleterious
dendritic cell
dendritic cells
determine
Diseases
double-stranded RNA
eight
enrichment
epidemiological studies
Exome
fibroblast
fibroblasts
Genes
genes encoding
genetic defect
genetic defects
genetics
Genome
genomics study
had milder phenotype
healthy individuals
highest
Hospitalized
Human
human fibroblasts with mutations
Hypothesis
identify
IFN
IFN response
IFN-α2
IFNAR1
IFNAR1 deficiency
IFNAR2
IFNs
IKBKG
immune system
Immunity
immunological
in healthy individuals
in some
in vitro
Inborn error
Inborn errors
incomplete penetrance
individual
induction pathway
Infection
infection with SARS-CoV-2
Infectious diseases
Influenza
influenza pneumonia
Influenza virus
inheritance
interferon
interferon regulatory factor
interferon regulatory factor 7
interferons
interferons (IFNs)
involved
IRF3
IRF7
IRF9
lack
life-threatening
likelihood
loci
LOF
loss-of-function
male
mechanism
Medical conditions
minor
minor allele frequency
molecular
molecule
molecules
monogenic inborn error
monogenic inborn errors
mutated
Mutation
NEMO
NEMO/IKBKG
Neutralizing
nonsynonymous variant
other variants
outcome
pathogen
pathogen-induced inflammation
pathway
Patient
patients
Perspective
plasmacytoid dendritic cells
pLOF
Pneumonia
predicted
Prevent
produced
rare variant
Rare variants
Regulation
respiratory
reveal
risk
risk factor
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 infection in vitro
Science
selected
sequenced
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
severe coronavirus disease
severe COVID-19
Severe COVID-19 pneumonia
severe disease
Severe infection
silent infection
Stat1
STAT2
subject
susceptible
TBK1
tested
Therapeutic benefit
this system
TICAM1
TICAM1/TRIF
tissue
TLR3
Toll-like receptor
Toll-like receptor 3
TRAF3
TRIF
Type
type I
Type I IFN
type I IFNs
type I interferon
UNC93B1
underlie
variant
variants
Viral
Viral illness
viral illnesses
[DOI] 10.1126/science.abd4570 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1126/science.abd4570 PMC 바로가기 [Article Type] Research Article
A new domestic cat genome assembly based on long sequence reads empowers feline genomic medicine and identifies a novel gene for dwarfism
긴 서열 판독을 기반으로 한 새로운 국내 고양이 게놈 어셈블리는 고양이 게놈 의학에 힘을 실어주고 왜소증에 대한 새로운 유전자를 식별합니다
Research Article
[키워드] aligned
allele
analyses
Analysis
Author
Biology
Biosynthesis
Cancer
candidate
cats
chromosome
complex
correlated
Deleterious
disease
distribution
duplication
dwarfism
expansion
facilitate
FBXW7
Felis
framework
Genome
genome assembly
genomic
genomic variation
Glucose
Health
help
Households
human gene
Human genetics
humans
identify
Impact
IMPROVE
information
involved
landscape
lead
Lineage
lymphoma
Mutation
mutations
nucleotide
patients
phenotype
Phenotypes
predicted
rare diseases
reference genome
resource
screened
sequence
sequence variation
significantly
Single nucleotide variant
single nucleotide variants
SNV
SNVs
Structural variant
structural variants
susceptibility
SVs
Tumor
tumor suppressor
UGDH
USA
utility
variant
Variation
whole genome sequence
[DOI] 10.1371/journal.pgen.1008926 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1008926 PMC 바로가기 [Article Type] Research Article
Predominance of positive epistasis among drug resistance-associated mutations in HIV-1 protease
HIV-1 프로테아제의 약물 내성 관련 돌연변이 중 양성 상위성의 우세
Research Article
[키워드] alleviate
antiretroviral drug
antiretroviral drugs
Author
capture
clinic
clinical observation
clinical observations
Clinical studies
clinical study
clinically
Combination
combinations
compensatory mutations
deep sequencing
Deleterious
deleterious effect
deleterious effects
drug
drug resistance
Effect
epistasis
Evolution
fitness
Genetic
genetic interactions
greatly reduce
HIV
HIV-1
Impact
in vitro
inhibitors
Interaction
interactions
involved
likelihood
long term
majority
mechanism
mutant
Mutation
mutations
observation
outcome
overcome
pandemic
patients
persistence
positive
Prophylaxis
protease
Protease inhibitor
protease inhibitors
reduce
Replication
resistance mutations
reversal
reversion
selection experiments
sequence
Support
T cells
therapy
Viral
viral genome
viral replication
[DOI] 10.1371/journal.pgen.1009009 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1009009 PMC 바로가기 [Article Type] Research Article