Small Interfering RNA Effectively Inhibits the Expression of SARS Coronavirus Membrane Gene at Two Novel Targeting SitesArticle Published on 2010-10-182022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] analyzed blocked conserved coronavirus Critical demonstrated downregulate downregulated Effect eGFP expression Gene Expression information interferon isolate isolates M gene membrane Membrane gene novel nucleotide nucleotide substitution occur post-transcriptionally Protein qRT-PCR Quantitative Region RNA RNA molecule RT-PCR SARS-CoV SARS-CoV infection SARS-CoV M semi-quantitative sequence significantly siRNA Site Small interfering RNA targeting tested upregulation viral genome viral infection [DOI] 10.3390/molecules15107197 PMC 바로가기 [Article Type] Article
MicroRNome Analysis Unravels the Molecular Basis of SARS Infection in Bronchoalveolar Stem CellsResearch Article Published on 2009-11-132022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] ACE2 Activation acute infectious disease acute respiratory syndrome Basis bronchoalveolar caused CD45 Cell cellular miRNA complex interaction coronavirus SARS-CoV Data analysis Deterioration develop diagnostic Disease progression downregulated downregulation enrichment analysis epithelial evade Factors host cell host–virus interaction immune Infection inflammatory chemokines interact knowledge lung lung failure lung tissue marker microRNA miRNA miRNAs molecular mechanism Mortality observation pathway Protein target pulmonary fibrosis Replication reveal SARS-CoV SARS-CoV infection severe spike Stage STEM stem cell subset suppress target target cell the SARS epidemic Transmission viral genome Viral transmission virus [DOI] 10.1371/journal.pone.0007837 PMC 바로가기 [Article Type] Research Article