The Characterization of Immunoprotection Induced by a cDNA Clone Derived from the Attenuated Taiwan Porcine Epidemic Diarrhea Virus Pintung 52 StrainArticle Published on 2018-10-042022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] antigenicity attenuation cDNA characterization Clinical signs clone comparable detectable determinant effective Effective vaccines elicited epidemic diarrhea facilitate fecal full-length cDNA Host immune response IgA immunogenic immunoprotection in vitro in vivo induced infectious clone inoculated less Modification neutralizing antibody titers parental PEDV plasma IgG replication kinetics reverse genetics strain Taiwan Vaccine vaccine platform Vero cells viral genome Viral load viral pathogenesis viral shedding virulent virus [DOI] 10.3390/v10100543 PMC 바로가기 [Article Type] Article
The S2 Subunit of Infectious Bronchitis Virus Beaudette Is a Determinant of Cellular TropismVirus-Cell Interactions Published on 2018-07-182022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] Amino acid avirulent bronchitis Cell cell tropism cellular tropism chick chimeric Combination coronavirus cultured cell cultured cells demonstrated determinant determine ectodomain Effective vaccines expressing genetics genomic glycoprotein growth IBV in vitro in vivo inactivated Infectious Bronchitis Virus information introduced involved kidney M41 observation primary cell produced progeny Region replicate responsible reverse genetic analysis S gene S glycoprotein S glycoproteins S1 and S2 S2 subunit S2′ S2′ cleavage strain subunit tropism Vaccine Vaccines Vero Cell Vero cells virulence virulent virus [DOI] 10.1128/JVI.01044-18 PMC 바로가기 [Article Type] Virus-Cell Interactions
Receptor-binding domain-based subunit vaccines against MERS-CoVArticle Published on 2014-11-202022-11-01 Journal: Virus research [Category] Coronavirus, MERS, [키워드] animal model assist caused coronavirus develop development domain effective Effective vaccines Human MERS MERS coronavirus MERS-CoV MERS-CoV vaccines Middle East Middle East respiratory syndrome Coronavirus Pandemics Protein provide RBD Receptor-binding domain researcher Safe Spread Subunit vaccine subunit vaccines syndrome Vaccine development Vaccines [DOI] 10.1016/j.virusres.2014.11.013 PMC 바로가기 [Article Type] Article
Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes모든 90개의 폐렴구균 혈청형에서 피막 생합성 유전자좌의 유전적 분석Research Article Published on 2006-03-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis antigenic variation Antisera bacterial pathogen bacterial polysaccharide bacterial polysaccharide biosynthesis system bacterial polysaccharide diversity Bentley Blood capsular biosynthesis capsular biosynthesis gene capsular biosynthesis genes capsular biosynthetic gene capsular biosynthetic genes capsular gene capsular polysaccharide capsular polysaccharide structures capsular polysaccharides capsular serotype Capsule children chromosomal coated coding complement Complete determined different disease DNA DNA sequence effective protein-conjugated Effective vaccines evade Evolution Express genetics host antibodies host antibody human immune response immunochemically immunogenic immunological reactivity introduced invasive bacterial pathogen knowledge locus mechanism molecular Pathogens pneumococcal disease pneumococcus polysaccharide capsule polysaccharide structure polysaccharide vaccine PROTECT S. pneumoniae selected sequence sequences sera serological profile serological profiles serotype serotypes Seven Streptococcus pneumoniae survival target The United States total size United States virulence [DOI] 10.1371/journal.pgen.0020031 PMC 바로가기 [Article Type] Research Article