Increased neutralization and IgG epitope identification after MVA-MERS-S booster vaccination against Middle East respiratory syndrome Research Published on 2022-07-192022-10-05 Journal: Nature Communications [Category] 바이오마커, 임상, [키워드] antibody Antibody titer baseline binding booster vaccination clinical trial conducted coronavirus epitope Epitopes evaluate exploratory expressing homologous humoral responses identify IgG immunization immunogenic Increased magnitude MERS-CoV Middle East neutralization Neutralizing pandemic participant Phase 1 RBD respiratory syndrome coronavirus responses S2 subunit Safe spike glycoprotein Support syndrome the receptor-binding domain trial participant trials two-dose regimen vaccination vaccine candidate [DOI] 10.1038/s41467-022-31557-0 [Article Type] Research
The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies수용체 결합 도메인 결합 특이적 인간 단일클론 항체를 사용하여 바이러스에 감염된 세포에서 SARS-CoV-2 스파이크 단백질의 세포 특성화Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] adopted antibody appearance appears attachment B cell B cells biological properties biological property can be used Cell cell-to-cell transmission characterization conformation conformational change convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient convalescent patient serum Convalescent patients cytoplasmic demonstrated early stage early stages electron microscopy epitope Epitopes Evidence exhibited FIVE focus furin future therapeutic Golgi complex host cell Human human monoclonal antibodies Human monoclonal antibody immunofluorescence microscopy immunological indicated infected cells infected with SARS-CoV-2 Infection Interaction isolate isolates Microscopy mitigate MONITOR monoclonal new virus occur offer Protein provided RBD reagent Receptor binding domain receptor binding domain (RBD) recognize required S protein S protein cleavage S protein RBD SARS- CoV-2 SARS-CoV-2 SARS-CoV-2 clinical isolates SARS-CoV-2 spike SARS-CoV-2-infected cell SARS-CoV-2-infected cells Singapore Specific spike staining the RBD the S protein therapeutic These data Transmission Vaccine variant virus infection virus particles virus-infected cell virus-infected cells was used were used while [DOI] 10.1128/jvi.00455-22 PMC 바로가기 [Article Type] Article
Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity1년 동안 SARS-CoV-2-특이적 T 세포 사이토카인 생성 반응에 대한 종단 평가는 질병 중증도와 관련된 더 큰 면역과 함께 다중 사이토카인 증식 반응의 지속성을 보여줍니다Article Published on 2022-07-132022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 all subjects assessment average CD4 CD8 Cell Cell-mediated immunity clone coronavirus Coronaviruses Critical cytokine cytokine response Cytokines declined demonstrated dominant ELISPOT ELISpot assay envelope enzyme-linked immunosorbent epitope Epitopes Ex vivo female Frequency gamma interferon granzyme B greater GzmB highlight IFN-γ IL-2 immune immune modeling. Immunity immunodominant immunodominant epitope immunodominant epitopes induce Infection interferon interleukin interleukin 2 kill longitudinal male median membrane nucleocapsid observation other coronaviruses peaked persistence post-symptom onset potent predicted produced producing proliferative PSO reduced regions response robust SARS-CoV-1 SARS-CoV-2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus severe disease structural protein structural proteins subject survivor T cell T cell immunity T cell memory T cell response T cell responses T cells target cells Vaccine viral infections Year [DOI] 10.1128/jvi.00509-22 PMC 바로가기 [Article Type] Article
A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection단일 T 세포 에피토프를 사용한 세 번째 백신 접종은 SARS-CoV-2 감염의 쥐 모델에서 보호를 제공합니다Article Published on 2022-07-082022-09-12 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absence approach booster vaccination CD8 characterized cytokine production develop dose dose regimen elicit epitope epitope peptide fraction IMPROVE K18-hACE2 mechanism memory T cells murine model Neutralizing antibodies peptide repeated SARS-CoV-2 SARS-COV-2 infection spike T cell T cell response Transgenic mouse understanding vaccination Vaccine vaccine dose [DOI] 10.1038/s41467-022-31721-6 PMC 바로가기 [Article Type] Article
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses치명적인 COVID-19 결과는 풍토성 코로나바이러스와 공유되는 에피토프를 표적으로 하는 항체 반응과 관련이 있습니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] Adaptive immunity antibody Antibody Response Antibody responses antigenic beta-coronavirus characteristic conservation coronavirus coronavirus disease Coronavirus disease 2019 correlated strongly correlation COVID-19 cross-reactive disease Disease progression domain Endemic epitope Epitopes fatal COVID-19 full-length spike protein highest ICU immune response immune responses immunology Imprinting individual Infection Infectious disease intensive care intensive care unit less magnitude not significantly different nucleocapsid outcome outcomes proportion Protective Region respiratory Respiratory Coronavirus response S2 subunit SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 spike protein severe acute respiratory coronavirus Spike protein Spike proteins subunits the antibody response the SARS-CoV-2 variable regions [DOI] 10.1172/jci.insight.156372 PMC 바로가기 [Article Type] Article
A booster dose of Delta × Omicron hybrid mRNA vaccine produced broadly neutralizing antibody against Omicron and other SARS-CoV-2 variantsDelta × Omicron 하이브리드 mRNA 백신의 추가 용량은 Omicron 및 기타 SARS-CoV-2 변이체에 대한 광범위 중화 항체를 생성했습니다.Article Published on 2022-07-072022-09-11 Journal: Journal of Biomedical Science [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antigenic approach booster dose CD8+ conserved COVID-19 cross-protective Cross-protectivity Delta Delta variants develop Efficacy elicited epitope feasible hybrid Hybrid vaccine Immune escape immunized Inclusion mice mRNA vaccine mRNA-based vaccine Mutation naïve Neutralizing Neutralizing antibodies neutralizing antibody new SARS-CoV-2 Next generation vaccine omicron Omicron vaccine produced RBD Receptor binding domain SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants shown specific neutralizing antibodies T cell T cell response T cell responses tested Transmission Vaccine Vaccine design Vaccines variant variants variants of concern VOCs wild type wild-type [DOI] 10.1186/s12929-022-00830-1 PMC 바로가기 [Article Type] Article
A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including OmicronOmicron을 포함한 모든 SARS-CoV-2 스파이크 변이체의 보존된 숨겨진 틈을 인식하는 나노바디 패널Article Published on 2022-07-062022-09-11 Journal: Communications Biology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] Accessibility Analysis antibodies antibody caused clone conserved Contact coronavirus COVID-19 detect diagnostics ELISA epitope Epitopes FIVE flow cytometric hidden Human Imbalance Infectious disease kinetic lateral flow Medicines Microscopy N-terminal domain nanobodies nanobody neutralize NTD omicron pandemic populations pseudotyped RBD Receptor-binding domain recognizing regions SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 spike proteins SARS-CoV-2 spike variant SARS-CoV-2 variant Spike proteins spike variants target the receptor-binding domain the spike protein Vaccines Viral viral infection VOCs western blotting [DOI] 10.1038/s42003-022-03630-3 PMC 바로가기 [Article Type] Article
ATM-TCR: TCR-Epitope Binding Affinity Prediction Using a Multi-Head Self-Attention ModelArticle Published on 2022-07-062023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] adaptive immunotherapy Antigen binding affinity epitope machine learning self-attention model. TCR [DOI] 10.3389/fimmu.2022.893247 PMC 바로가기
A structural homology approach to identify potential cross-reactive antibody responses following SARS-CoV-2 infection Research Published on 2022-07-062022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 치료제, [키워드] anti-SARS-CoV-2 antibody approach clinical observation clinical presentation contribute COVID-19 Critical cross-react cross-reactive antibody disease domain driving epitope evaluate function human protein human proteins Hypothesis identify indication linear epitopes novel SARS-CoV-2 virus Pathologies pathology Protein response SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 Wuhan strain structural homology Therapies understanding unmet need with COVID-19 [DOI] 10.1038/s41598-022-15225-3 [Article Type] Research
COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteinsCOVID-19 백신 접종은 고유의 코로나바이러스 스파이크 단백질로 보존된 에피토프에 대한 진화하는 교차 반응성 항체 반응을 이끌어냅니다Article Published on 2022-07-052022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Alanine antibody conserved coronavirus coronavirus spike protein CoV COVID-19 pandemic COVID-19 vaccination CoVs CP: Immunology CP: Microbiology cross-reactive cross-reactive antibody detectable elicit Endemic epitope Epitopes experiments homolog identify Immunity immunology longitudinal samples mechanism Microbiology mRNA mRNA-1273 mRNA-1273 vaccine multiplexed serology observé other coronavirus other coronaviruses phylogenetically reactivity regions residue SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology spike subject the vaccine trajectory triggered vaccination vaccine response vaccine-induced antibody response widespread [DOI] 10.1016/j.celrep.2022.111022 PMC 바로가기 [Article Type] Article