Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients점막 관련 불변 T(MAIT) 세포는 COVID-19 환자에서 고도로 활성화되고 기능적으로 손상됩니다Article Published on 2021-02-032022-09-01 Journal: Viruses [Category] MERS, 진단, [키워드] activated Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed Antiviral caused Cell cells contribute coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 cytokine cytokine expression profile Cytokines cytolytic disease disease severity Ex vivo Express expression flow cytometry granzyme B HLA-DR IL-17A immune system Immunopathogenesis Impaired in vitro Infection lung marker measure Mild mucosal-associated invariant T (MAIT) cells Organ failure Pathogenesis pathogenesis of COVID-19 Patient patients with COVID-19 perforin phenotype positively correlated progression Proinflammatory cytokine proinflammatory cytokines Proteins respiratory SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe COVID-19 severe disease T cell T cells TNFα [DOI] 10.3390/v13020241 PMC 바로가기 [Article Type] Article
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas Research Published on 2021-02-032022-10-05 Journal: Nature metabolism [Category] 치료기술, [키워드] acute respiratory syndrome Cell cells changes clinical contribute coronavirus coronavirus disease COVID-19 diabete dysregulation Endocrine Ex vivo experimental evidence Express functional Glucose Granule homoeostasis identify impair in vivo infect Infection insulin investigated islet islets marker Morphological pancrea pancreatic Patient patients with COVID-19 positive postmortem examinations Protein Proteins reduced replicate SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid secretion tissue transcriptional viral entry β-cell [DOI] 10.1038/s42255-021-00347-1 [Article Type] Research
Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized COVID-19 patients입원한 코로나19 환자의 혈장 조직 플라스미노겐 활성제 및 플라스미노겐 활성제 억제제-1Article Published on 2021-01-152022-09-10 Journal: Scientific Reports [Category] 바이오마커, 치료법, [키워드] Antigen approach assays balance Biomarker Biomarkers bleeding Cardiovascular biology Coagulation complex Complication coronavirus coronavirus disease Coronavirus disease-19 correlated correlation COVID-19 COVID-19 patients demonstrated elevated ENhance Ex vivo expressing Factor favor fibrinolysis fibrinolytic healthy control help high risk homeostasis hospitalized COVID-19 patient in some lysis marker Mortality neutrophil neutrophil activation neutrophil count neutrophil counts Patient patients patients hospitalized performed plasma Prophylaxis respiratory status significantly subset Therapies These data thrombosis Thrombosis prophylaxis thrombotic tissue plasminogen activator understanding utility venous viral infection while with COVID-19 [DOI] 10.1038/s41598-020-80010-z PMC 바로가기 [Article Type] Article
Host and viral determinants for efficient SARS-CoV-2 infection of the human lungArticle Published on 2021-01-082022-10-29 Journal: Nature Communications [Category] COVID-19, [키워드] ACE2 addition contribute determinant epithelial cell Ex vivo Factor furin-like cleavage site Host human cell human lung identify Infection Intervention intestinal tissues involved lung epithelial cell lung tissues Lungs Pathogenesis Prevent required restriction factor SARS-CoV infection SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike sialic acid target tissue tissues Transmissibility understanding viral infection virus replication while [DOI] 10.1038/s41467-020-20457-w PMC 바로가기 [Article Type] Article
Experimental Models to Study COVID-19 Effect in Stem CellsReview Published on 2021-01-072022-10-31 Journal: Cells [Category] COVID-19, MERS, [키워드] acute respiratory distress acute respiratory syndrome addition ARDS can be used cause Cell clinically Consequences coronavirus coronavirus disease COVID-19 COVID-19 virus development disease Drug efficacy Effect epithelial Ex vivo experimental model global pandemic hypoxic respiratory failure induce Inflammatory mechanism of action Model model system new strain organoid system organs resulting SARS-CoV-2 STEM stem cell stem cells syndrome tissue virus virus infectivity [DOI] 10.3390/cells10010091 PMC 바로가기 [Article Type] Review
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis PatientsCommunication Published on 2021-01-032022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] ACE2 Activation angiotensin-converting enzyme 2 Antibiotics Cell Cystic cystic fibrosis dACE2 demonstrated diffusion Ex vivo examined expression fibrosis full-length furin Gene Expression Genes healthy control healthy donors IFN IFN-I IFNβ individual Inhaled interferon ISG15 isoform Lower marker nasopharyngeal cells pancreatic Patient positive correlation Proteases receiving receptor reduction relation response SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection stimulated the healthy TMPRSS2 transmembrane serine protease type I interferon upper respiratory sample upregulation [DOI] 10.3390/microorganisms9010093 PMC 바로가기 [Article Type] Communication
Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19임상 분석 및 만능 줄기 세포 기반 모델은 COVID-19에 취약한 유아에 대한 ACE2 및 폐 전구 세포의 가능한 영향을 보여줍니다Multicenter Study Published on 2021-01-012022-09-01 Journal: Theranostics [Category] 진단, 치료기술, [키워드] ACE2 ACE2 expression age Alveolar Type II analysed Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biopsies Cell cells children children with COVID-19 clinical clinical feature Clinical features Cohort Combination contributing to cooperation coronavirus disease Coronavirus disease 2019 COVID-19 derivative develop developmental developmental stages disease severity distribution double positive cell double positive cells Ex vivo examined expressed expression expression level expression levels expression pattern expression patterns immune response immune system Impact Infant Infants infections lung lung biopsies lung cell lung cells lung development lung injuries Lung injury lung progenitor cells Lungs number of children Older pluripotent stem cells Pneumonia positive profiles progenitor cell progenitor cells reported risk factor Risk factors RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 virus severe coronavirus disease significantly single cell RNA sequencing SOX9 Spectrum Stage stem cell Type vulnerability with COVID-19 [DOI] 10.7150/thno.53136 PMC 바로가기 [Article Type] Multicenter Study
SARS-CoV-2 Induces a More Robust Innate Immune Response and Replicates Less Efficiently Than SARS-CoV in the Human Intestines: An Ex Vivo Study With Implications on Pathogenesis of COVID-19SARS-CoV-2는 인간의 장에서 SARS-CoV보다 더 강력한 선천 면역 반응을 유도하고 덜 효율적으로 복제합니다.Article Published on 2021-01-012022-09-11 Journal: Cellular and molecular gastroenterology and hepato [Category] SARS, 치료기술, [키워드] Activation alternative route chemokines clinical observation clinical observations coronavirus disease Coronavirus disease 2019 COVID-19 Cytokines dissemination Ex vivo gastrointestinal tract Gene Expression Gut Hong Kong Human human liver immune activation immunohistochemistry indicated infect infected with SARS-CoV-2 Infection Infectious virus Innate innate immune response interferon interferons intestinal epithelium intestinal tissue intestinal tissues intestine kidney tissues less manifestation Particles Patient patients plaque assays pro-inflammatory cytokine pro-inflammatory cytokines processed qRT-PCR replicate replicated Replication replication kinetics reported respiratory response robust SARS-CoV SARS-CoV-2 suggested surgical surgical operation surgical removal tissue tissues type I type I and type III interferons type III Type III interferons virus [DOI] 10.1016/j.jcmgh.2020.09.017 PMC 바로가기 [Article Type] Article
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivoSARS-CoV-2 D614G 변이체는 생체 외에서 효율적인 복제 및 생체 내 전달을 나타냅니다.Report Published on 2020-12-182022-09-10 Journal: Science (New York, N.y.) [Category] MERS, SARS, 변종, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alter angiotensin animal models Antisera appear both virus both viruses change Changing Characteristics China coronavirus D614G D614G substitution D614G variant dominant Effect Efficacy ENhance enzyme epithelial cell epithelial cells Ex vivo exhibit experiment faster glycine greater greater transmissibility hamster hamsters Human human Angiotensin-converting enzyme human cell human cells in vitro in vivo indicate infecting Infection maintain morphology Mutation neutralization Neutralizing new virus pandemic spread Pathogenesis pathogenicity Population prevalent primary human airway Primary human airway epithelial cells primary human cell primary human cells pulmonary disease replaced REPLACED BY replicate Replication respiratory respiratory tissue respiratory tissues SARS-CoV-2 SARS-CoV-2 D614G SARS-CoV-2 variant Science severe acute respiratory syndrome Coronavirus significantly Spike protein strain Strains susceptible the times These data transgenic mice Transmissibility Transmission vaccine candidate vaccine candidates variant variant of SARS-CoV-2 Viral viral pathogenesis viral spike protein viral titer virulence virus viruses wild-type virus [DOI] 10.1126/science.abe8499 PMC 바로가기 [Article Type] Report
Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity무배양 게놈 전체 유전자좌 서열 유형 지정(GLST)은 트리파노소마 크루지 분산 및 감염 복잡성에 대한 새로운 관점을 제공합니다.Research Article Published on 2020-12-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] agarose gel alternate allele frequency amplification amplify analyzed approach biases capture capture method Cell Chagas disease Chain Reaction city clone Co-infection collected Complete complex correlation correlations Culture detect dispersal distribution DNA Ecuador epidemiological epidemiological surveillance evaluate Ex vivo flexible frequency distributions generate Genetic Genetic polymorphism Genetic variation Genome genomes genotyping hotspot identify infecting Infection infection source Infectious disease Infectious diseases information intestinal involved library limitation lineages locus marker metagenomic minimum parasite parasites pathogen Pathogenic microorganisms Perspective polymerase chain polymerase chain reaction polymerase chain reactions polymorphism powerful tool primer principle provide purification representing Research Result sequence Sequencing single-nucleotide Single-nucleotide polymorphisms SNP Spectrum Strains subsequent subset Surveillance target target pathogen Trypanosoma Trypanosoma cruzi vector Venezuela [DOI] 10.1371/journal.pgen.1009170 PMC 바로가기 [Article Type] Research Article