Pre-exposure Prophylaxis With Various Doses of Hydroxychloroquine Among Healthcare Personnel With High-Risk Exposure to COVID-19: A Randomized Controlled TrialPreventive Medicine Published on 2021-12-212022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Antibody testing clinical benefit conducted confirmed COVID-19 case control group Controlled coronavirus coronavirus disease COVID 19 COVID-19 COVID-19 symptom dose Efficacy Enrollment evaluate exhibiting experimental group exposure to hcp HCQ healthcare personnel Hydroxychloroquine IgM/IgG Infection objective participant Participants patients Personal protective equipment Placebo placebo-controlled trial PPE pre-exposure prophylaxis Prevent Prophylaxis Randomized reported Result RT-PCR SARS-CoV-2 serology testing Side effect significantly study outcome subject tested the patient treated Trial [DOI] 10.7759/cureus.20572 PMC 바로가기 [Article Type] Preventive Medicine
Sharing a household with children and risk of COVID-19: a study of over 300 000 adults living in healthcare worker households in Scotland어린이와 함께 가구 공유 및 Covid-19의 위험Original Research Published on 2021-12-182022-09-10 Journal: Archives of Disease in Childhood [Category] SARS, 유전자 메커니즘, [키워드] 95% CI adjusted association Child children cohort study Contact contact with COVID COVID-19 Epidemiology Evidence exposure to healthcare worker hospitalisation house household household contact investigated less National Health Service number objective outcome over parent Positive test potential mechanisms reduce reduced respiratory respiratory viral infections Result risk risk of COVID-19 SARS-CoV-2 School Schools setting statistically significant study period study population Viral was reduced [DOI] 10.1136/archdischild-2021-321604 PMC 바로가기 [Article Type] Original Research
Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for PathogenicityArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 air–liquid interface Alpha Altered alveolar Analysis anti-viral response bronchial bronchial epithelial cell canonical cell membrane coronavirus COVID-19 COVID-19 vaccines cytokine differentially regulated gene Effect enzyme exposure to expression fibrosis host cell receptor Human IFN IFNγ IL10 IL12 IL13 IL2 IL4 IL6 IL8 Infection Influenza integrin interferon Ligand lung Lung fibrosis MERS (middle east respiratory syndrome) mRNA-based mucosa Mutation Necrosis neutralizing antibody p53 pathogenicity pathway platform pro-fibrotic pro-inflammatory cytokine pulmonary receptor Receptor binding domain Recombinant S1 protein regions robust S1 protein S1 subunit SARS (severe acute respiratory syndrome) SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant secreted Signaling significantly spike spike glycoprotein Spike protein the S1 subunit TLR TLR4 Type II pneumocyte virus [DOI] 10.3390/v13122537 PMC 바로가기 [Article Type] Article
Efficacy of Ventilation, HEPA Air Cleaners, Universal Masking, and Physical Distancing for Reducing Exposure to Simulated Exhaled Aerosols in a Meeting RoomArticle Published on 2021-12-172022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACh aerosol aerosol exposure breath cause COVID-19 droplet effective Evidence exposure to HEPA HEPA air cleaner highest increase in increases in individual indoor exposure masking meeting optical Particle Particles physical distancing recipient reduce reduced reducing reduction released respiratory aerosol respiratory fluid risk room SARS-CoV-2 shown Source Spread transmission of SARS-CoV-2 uninfected Universal Universal masking vaccination Ventilation virus while [DOI] 10.3390/v13122536 PMC 바로가기 [Article Type] Article
A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences Research Published on 2021-12-172022-10-05 Journal: Neuropsychopharmacology [Category] 비임상, [키워드] anhedonia Care cohorts depressive develop disorder ELA exposure to generate group healthy Human humans illness impacted implicated Interaction lack measure Mental neuropsychiatric conditions participant Patient Phenotypes populations Probing provoke quantified reactivity recent rodent sensitivity Signaling significantly higher These data [DOI] 10.1038/s41386-021-01250-9 [Article Type] Research
No neutralizing effect of pre-existing tick-borne encephalitis virus antibodies against severe acute respiratory syndrome coronavirus-2: a prospective healthcare worker study심각한 급성 호흡기 증후군 코로나 바이러스에 대한 기존의 진드기 매개 뇌염 바이러스 항체의 중화 효과 없음 : 전향 적 건강 관리 근로자 연구Article Published on 2021-12-172022-09-01 Journal: Scientific Reports [Category] SARS, 진단, [키워드] 95% CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adjusted adjusted odds ratio antibodies antibody Antibody titer Antibody titers association baseline Cohort contribute Coronavirus-2 cross-protection Encephalitis explained exposure to Factors Follow-up HCW healthcare worker IgG immune activation immunization increase in knowledge Laboratory testing Neutralization assay Neutralizing neutralizing effect non-specific participant Pathogens protective role reduced risk residual confounding respiratory SARS-CoV-2 SARS-COV-2 infection Seroconversion serostatus Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significantly higher suggested These data tick-borne encephalitis tick-borne encephalitis virus vaccination viral infection virus [DOI] 10.1038/s41598-021-03685-y PMC 바로가기 [Article Type] Article
The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular diseaseCardiovascular System & Vascular Biology Published on 2021-12-152022-10-31 Journal: Clinical Science (London, England : 1979) [Category] COVID-19, SARS, [키워드] ACE2 Activation acute respiratory syndrome alterations angiotensin converting enzyme 2 angiotensin-converting enzyme 2 antibody cause caused CD147 Cell cellular clinical response contributing to coronavirus COVID-19 death disease disrupt dysfunction elicited Endothelial cell events exposure to Extracellular Factor functional Hypothesis Implications in vitro induce infect infected patients Infection involved Ligand mechanism Microvascular damage Microvascular disease microvascular injury Migration mRNA neutralisation Patient pericyte Peripheral blood pro-apoptotic pro-inflammatory molecule Protein receptor recombinant S protein reduced rescued S protein SARS-CoV-2 secretion spike Spike protein stimulate Stress Support tested the cytokine storm the S protein the SARS-CoV-2 therapeutic variant Vascular wildtype [DOI] 10.1042/CS20210735 PMC 바로가기 [Article Type] Cardiovascular System & Vascular Biology
Risk-focused differences in molecular processes implicated in SARS-CoV-2 infection: corollaries in DNA methylation and gene expressionSARS-CoV-2 감염과 관련된 분자 과정의 위험 중심적 차이: DNA 메틸화 및 유전자 발현의 결과Research Published on 2021-12-112022-09-11 Journal: Epigenetics & Chromatin [Category] SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Air pollutants airway epithelia Analysis ARRB2 association Asthma autosomal Bronchoalveolar lavage CA5B candidate gene changes in chronic conditions chronic obstructive COMT conducted COPD coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 susceptibility CpG data set Diagnosis diesel exhaust DNA methylation downloaded epithelia exaggerated immune response exhibited explain Exploratory analysis exposure to Factor female Gene Expression gene expression patterns Genes GEO GPX1 Health highlight HS6ST2 immune genes imperative implicated inactivation increased risk individual Infection infections investigated involved loci lung magnitude male molecular molecular association molecular associations molecular basis molecular pattern molecular patterns mRNA expression nasal Nicotine nicotine dependence nitrogen nitrogen dioxide NLRP2 outcomes portal PRIM2 profile Repository respiratory Respiratory conditions Respiratory disease respiratory tissue Result risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection second severe acute respiratory syndrome Coronavirus Sex Sex difference Smokers smoking suggested supplementary material susceptibility TATDN1 the disease TLE1 understanding Variation while Whole blood X-linked X-linked gene [DOI] 10.1186/s13072-021-00428-1 PMC 바로가기 [Article Type] Research
Emergence of SARS-CoV-2 resistance mutations in a patient who received anti-SARS-COV2 spike protein monoclonal antibodies: a case report항 -SARS-COV2 스파이크 단백질 단일 클론 항체를받은 환자에서 SARS-COV-2 저항 돌연변이의 출현 : 사례 보고서Case Reports Published on 2021-12-072022-09-01 Journal: BMC Infectious Diseases [Category] SARS, 변종, 진단, [키워드] B.1.1.7 B.1.1.7 variant Case report Combination coronavirus disease Coronavirus disease 2019 COVID-19 E484K emergence exposure to Immunosuppressed in vitro Infection K417N management measure monoclonal monoclonal antibodies monoclonal antibody Mutation offer Patient Protein raise receiving Resistance mutations selection respiratory SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Severe case spike Spike protein subsequent therapeutic Transmission variants virus [DOI] 10.1186/s12879-021-06902-1 PMC 바로가기 [Article Type] Case Reports
DrugWAS: Drug-wide Association Studies for COVID-19 Drug RepurposingDrugWAS: COVID-19 약물 용도 변경에 대한 약물 전반의 협회 연구Article Published on 2021-12-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] MERS, 신약개발, [키워드] 95% CI 95% confidence interval Admission Analysis applied association azelastine center clinical trials cohort study coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 severity death Dextromethorphan diphtheria toxoid drug drugs Efficacy EHR EHR data Electronic health record estradiol ethinyl estradiol exposure to fatty acids Flaxseed fluticasone Health health record ibuprofen identify IMPROVE intensive care intensive care unit list lower risk mechanical ventilation multivariable logistic regression Odds ratio omega-3 Omega-3 fatty acids outcomes overlap pandemic patients with COVID-19 performed pertussis vaccine pneumococcal polysaccharide vaccine Potential treatment Primary outcome Propensity score pseudoephedrine randomized clinical trial repurposing retrospective cohort risk of death secondary Secondary analyses Secondary outcomes significantly tetanus toxoid ubidecarenone university Vaccine Vaccines was selected Weighting [DOI] 10.1002/cpt.2376 PMC 바로가기 [Article Type] Article