Identification of the SHREK Family of Proteins as Broad-Spectrum Host Antiviral FactorsArticle Published on 2021-05-042022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] addition Antiviral block CD164 CD34 CD43 Cell cellular Characteristics domain Extracellular Factor family glycoprotein glycosylated Ha-CoV-2 HIV-1 Host host innate immunity identification Infection influenza A inhibiting MUC1 MUC4 mucin P-selectin PODXL1 PODXL2 Protein Proteins pseudovirus PSGL-1 restrict SARS-CoV-2 SHREK subset surface protein target cells TMEM123 virion virus viruses [DOI] 10.3390/v13050832 PMC 바로가기 [Article Type] Article
Hybrid physiologically-based pharmacokinetic model for remdesivir: Application to SARS-CoV-2렘데시비르에 대한 하이브리드 생리학적 기반 약동학 모델: SARS-CoV-2에 적용Article Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 치료제, [키워드] anti-SARS-CoV-2 Antiviral agents application can be used catastrophic caused Concentration condition conducted coronavirus disease Coronavirus disease 2019 COVID-19 determine effective Extracellular half-maximal effective concentration Health humans hybrid impacted imperative in vitro indicated lung Lungs metabolite mononuclear cell Multiple-dose Novel coronavirus pandemic parameter patients Peripheral blood Peripheral blood mononuclear cells pharmacokinetic prodrug profiles ranged RDV regimen regimens Remdesivir reported SARS-CoV-2 sensitivity analysis Severe acute respiratory syndrome target tissues Therapeutic treatment tissue [DOI] 10.1111/cts.12975 PMC 바로가기 [Article Type] Article
Assessment of Body Composition and Dietary Intake in Nursing-Home Residents: Could Lessons Learned from the COVID-19 Pandemic Be Used to Prevent Future Casualties in Older Individuals?Clinical Trial Published on 2021-04-292022-10-04 Journal: Nutrients [Category] MERS, SARS, 임상, [키워드] accompanied Adiposity Adults analyzed assessment association Body body composition body fat body fluids body water bone Care casualty category Chronic diseases components COVID-19 COVID-19 infections dietary dietary intake evaluated Extracellular fat fatty acids fiber Future Health high risk highest inflammatory state intake lesson majority Malnutrition Micronutrient muscle mass nutritional status Older Older adults omega-3 OSA osteopenic/osteoporotic adiposity osteosarcopenic adiposity participant Participants Prevalence Protein recall recommendations risk S-score sarcopenic sarcopenic adiposity syndrome T-score women [DOI] 10.3390/nu13051510 PMC 바로가기 [Article Type] Clinical Trial
Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2–Priming Protease TMPRSS2Research Article Published on 2021-04-262022-10-28 Journal: Pathogens and Immunity [Category] COVID-19, [키워드] ACE2 affecting Alpha Alpha 1 antitrypsin angiotensin-converting enzyme 2 antitrypsin binding Camostat mesylate cell entry complexes coronavirus coronavirus S protein Coronaviruses COVID disease severity dissemination docked domain effective Extracellular FDA-approved drug host cells identify implicated Infection membrane MERS plasma priming protease receptor SARS CoV-2 SARS-CoV SARS-CoV-2 SARS-CoV-2 viral load serine protease serine protease inhibitor suggested Support the S protein TMPRSS2 TMPRSS2 inhibitor TMPRSS2 inhibitors Treatment with COVID-19 [DOI] 10.20411/pai.v6i1.408 PMC 바로가기 [Article Type] Research Article
Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptomsResearch paper Published on 2021-04-162022-10-30 Journal: Journal of Translational Autoimmunity [Category] COVID-19, [키워드] α1-fAAB, Autoantibody targeting the alpha1-adrenoceptor β2-fAAB, Autoantibody targeting the beta2-adrenoceptor fAAB, Functional autoantibody ACE2, Angiotensin-converting enzyme 2 receptors activate acute phase agonists analysed AT1 AT1-fAAB, Autoantibody targeting the angiotensin II AT1 receptor autoantibodies autoantibody Autoimmunity Blood cardiological cardiovascular disease cardiovascular disorder caused cells Combination Combined COVID COVID-19 COVID-19 patient CRPS, Complex regional pain syndrome detectable ETA-fAAB, Autoantibody targeting the endothelin receptor Extracellular fatigue Follow-up G-protein GPCR, G-protein coupled receptors Health independent investigated involved long-COVID M2-fAAB, Autoantibody targeting the muscarinic receptor MAS-fAAB, Autoantibody targeting the MAS receptor muscarinic negative chronotropic Neonatal neurological Neurological deficit NOC-fAAB, Functionally active autoantibody against the nociceptin receptor Occurrence opposite Other Patient patients positive chronotropic Post-covid-19 symptom PoTS, Postural orthostatic tachycardia syndrome RAS, Renin angiotensin system receptor receptors recovered COVID-19 patient reported SARS-CoV-2 SARS, Severe acute respiratory syndrome Symptom Symptoms syndrome target receptor the disease [DOI] 10.1016/j.jtauto.2021.100100 PMC 바로가기 [Article Type] Research paper
The C-Terminal Domain of Nef mut Is Dispensable for the CD8 + T Cell Immunogenicity of In Vivo Engineered Extracellular VesiclesArticle Published on 2021-04-122022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Antigen C-terminal C-terminus CD8 CD8+ T cell immunity cells deleted diffusion distal DNA DNA immunization effective elicit EVs expressing Extracellular Extracellular vesicles full-length fused Heterologous HIV-1 Nef HPV vaccines humans immune response Immunity immunogenicity injection isoform MOST not affect Perspective preserved Protein released S1 and S2 safety profile SARS-CoV-2 SARS-CoV-2 vaccines stability T cell translation tumor antigen Vaccine vaccine platform vector Vesicle [DOI] 10.3390/vaccines9040373 PMC 바로가기 [Article Type] Article
Difficulties in Differentiating Coronaviruses from Subcellular Structures in Human Tissues by Electron Microscopy전자 현미경으로 인간 조직의 세포 내 구조에서 코로나바이러스를 구별하는 데 어려움Review Published on 2021-04-012022-09-10 Journal: Emerging Infectious Diseases [Category] MERS, SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition caused characteristic coated coronavirus coronavirus disease COVID-19 COVID-19 patient cross damage difficulty electron electron microscopy Endoplasmic reticulum Extracellular focus Human investigator investigators less membrane-bound morphologic feature morphologic features multivesicular bodies negative stain nucleocapsid pandemic Particles pathology reported respiratory respiratory infections SARS SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Structure subcellular structures thin sections tissue damage tissues transmission electron microscopy ultrastructure vesicles virus viruses zoonoses [DOI] 10.3201/eid2704.204337 PMC 바로가기 [Article Type] Review
Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunityCOVID-19 및 자가면역에서의 인터페론 및 기타 사이토카인, 유전학 및 그 이상Review Published on 2021-04-012022-09-11 Journal: Cytokine & growth factor reviews [Category] 유전자 메커니즘, [키워드] Alpha antibodies antibody antiviral agent Antiviral agents autoantibodies autoantibody Autoimmune Autoimmune disease Autoimmune diseases Autoimmunity B cell cascade Citrullination complement COVID-19 COVID-19 patient COVID-19: antibody cytokine Cytokines Degradation deletions develop Epitopes Extracellular gene defect Gene segment Genetic genetic defect genetic defects genetics glycosylation growth factor Growth factors hematological homozygous hypotheses immunological Immunological studies in vitro induce Infection innate immune interferon Interferon-beta interferons intracellular content intracellular protein intracellular proteins involved lupus erythematosus mechanism MOST neutralization Neutralizing Neutralizing antibodies neutralizing antibody Occurrence Patient POLE posttranslational modifications protease PROTECT proteolysis question regulated Release Research SARS-CoV-2 Seven severe COVID-19 severe inflammation Signaling systemic lupus erythematosus the SARS-CoV-2 Tolerance type 1 interferons virus virus infection virus replication [DOI] 10.1016/j.cytogfr.2021.01.004 PMC 바로가기 [Article Type] Review
Evidence for CAT gene being functionally involved in the susceptibility of COVID-19CAT 유전자가 COVID-19의 감수성에 기능적으로 관련되어 있다는 증거Review Published on 2021-04-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] SARS, 변종, [키워드] ACE2 ACE2 protein acting addition affecting Analysis binding bioinformatics Bioinformatics analysis candidate gene caused Cell cell membrane coronary pneumonia coronavirus COVID-19 disease distress DNA variants Effectiveness EHF eQTL Evidence expression Extracellular Genes Genetic Genetic variant genetic variants Genome-wide association study GWASs Interaction Intracellular Invasion involved Lungs molecular novel positive correlation potential risk Prognosis Protein Protein binding protein interaction regulate regulated reported respiratory distress Respiratory distress syndrome S protein starting susceptibility syndrome Treatment understanding variant [DOI] 10.1096/fj.202100008 PMC 바로가기 [Article Type] Review
Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signaturesSARS-CoV-2 및 H1N1 폐 손상의 공간 매핑은 차등 전사 서명을 식별합니다Report Published on 2021-03-232022-09-10 Journal: Cell Reports Medicine [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, 진단, [키워드] Abstract acute respiratory distress acute respiratory distress syndrome alveolar epithelium anti-viral response anti-viral responses antiviral response ARDS Autopsy both viruses cellular change Coagulopathy COVID-19 demonstrated double infection dual enhanced Extracellular gene signature H1N1 H1N1 influenza identify induced genes infected individual Influenza Injury leads lung Lung injury lung tissue Macrophage macrophage activation macrophages pathway patients with SARS-CoV-2 phenotype platform Post-mortem Region remodeling respiratory distress response SARS-CoV-2 SARS-CoV-2 ARDS SARS-COV-2 infection SARS-CoV-2 infections severe SARS skewed spatial transcriptomics squamous metaplasia syndrome therapeutic target therapeutic targets tissue tissue remodeling transcriptional transcriptional change Transcriptome transcriptomic Type II pneumocyte type II pneumocytes unique Vascular injury vascular tissue Viral viral infections [DOI] 10.1016/j.xcrm.2021.100242 PMC 바로가기 [Article Type] Report