genetic variants – Page 14 – Communicable Diseases Research

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease

건강 및 면역 매개 질환의 여러 세포 유형에서 eQTL 매핑을 통한 유전자형-표현형 연관성에 대한 통찰력

Research Article

Published on 2016-03-252022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

Role of APOBEC3F Gene Variation in HIV-1 Disease Progression and Pneumocystis Pneumonia

HIV-1 질병 진행 및 기포자폐렴에서 APOBEC3F 유전자 변이의 역할

Research Article

Published on 2016-03-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 95% CI acquisition Affect AIDS allele Americans antiviral activity APOBEC3 cytidine deaminase APOBEC3F APOBEC3G association cohorts collaboration cytidine cytidine deaminases Degradation degrade demonstrated disease Disease progression ENCODE epidemiological European Evidence Factor Frequency gene family Genetic genetic association Genetic variant genetic variants Genomics Haplotype hazard HIV HIV disease HIV-1 host susceptibility Human in vitro in vitro experiments in vivo intrinsic modify modulate Pathogenesis pathway performed Pneumonia progression Protein Proteins provide reduced relative resistance factors resolved role significantly lower SNP validation study variant Viral viral infectivity Viral load
[DOI] 10.1371/journal.pgen.1005921 PMC 바로가기 [Article Type] Research Article

New genetic variants of influenza A(H1N1)pdm09 detected in Cuba during 2011-2013

Article

Published on 2015-06-012023-06-24
Journal: Infection, genetics and evolution : journal of mol
[Category] 신종인플루엔자,

[키워드] Cuba genetic variants influenza.
[DOI] 10.1016/j.meegid.2015.03.028 PMC 바로가기

Genome-Wide Association Studies Reveal a Simple Genetic Basis of Resistance to Naturally Coevolving Viruses in Drosophila melanogaster

Genome-Wide Association Studies는 Drosophila melanogaster에서 자연적으로 공진화하는 바이러스에 대한 저항성의 단순한 유전적 기초를 보여줍니다

Research Article

Published on 2012-11-152022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] a major alleles Antiviral appear Author Basis caused DCV disease disease susceptibility Drosophila Drosophila melanogaster explain expression found Frequency fruit Genes Genetic genetic component Genetic variant genetic variants Genetic variation Genome-wide association studies Genome-wide association study GWAS heritability identify inbred line inbred lines individual infect Infected Infectious disease insect Insects knocking down Mutation natural selection Naturally polymorphism Polymorphisms populations resistance resistance to infection RNAi shown simple susceptibility susceptible understanding variant Variation Viral viral infection virus virus resistance viruses
[DOI] 10.1371/journal.pgen.1003057 PMC 바로가기 [Article Type] Research Article

A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation

사르데냐인의 염증 표지자 수준에 대한 게놈 전체의 연관성 스캔은 복잡한 조절을 뒷받침하는 연관성을 보여줍니다

Research Article

Published on 2012-01-262022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] ABO gene AIRE APOC-I approach association associations Author autosomal C-reactive protein CADM3 CCR2 Cohort common disease complex conducted CR1 CRP CRP gene damaged cells DARC detect different different diseases Effects erythrocyte sedimentation erythrocyte sedimentation rate ESR Evidence Factor found functional Gene genetic determinant genetic determinants Genetic variant genetic variants genome-wide association scan Genome-wide association scans genome-wide significant genotyped GWAS HBB Health help High-sensitivity C-reactive protein highlight HNF1A hsCRP ICOSLG identifying IL-6 IL-6R gene ImmunoChip implicated IMPROVE included independent individual individuals Inflammation inflammation erythrocyte sedimentation rate Inflammatory biomarker interleukin interleukin-6 knowledge large cohort led to Level loci MCP-1 mechanism MetaboChip custom arrays molecular mechanism molecular mechanisms monocyte monocyte chemotactic protein-1 novel organism performed power pro-inflammatory molecule pro-inflammatory molecules Protective Protein provided QTLs Quantitative quantitative traits receptor Regulation replicated robust rs113459440 rs11829037 rs1205 rs12075 rs12567990 rs17141006 rs225918 rs3026968 rs3093077 rs3845624 rs4129267 rs4420638 rs4910472 rs657152 Sardinia Sardinian sedimentation rate selected SNP SPPL3 TMEM57 UCN119B UNC119B variant X chromosome SNP
[DOI] 10.1371/journal.pgen.1002480 PMC 바로가기 [Article Type] Research Article

Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility

보체 인자 H 및 인자 H 관련 유전자의 유전적 변이체와 전신성 홍반성 루푸스 감수성의 연관성

Research Article

Published on 2011-05-262022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation addition African American African Americans allelic American amplification Analysis Asian Asians association Author Autoimmune disease Case-control causal variant CFH CFHR1 CFHR3 CFHR4 CFHR5 chromosome chromosome 1q32 complement Complement activation complex contribute datasets Deletion described detected disease-associated downstream dysregulated Ethnic groups European Evidence exonic exonic SNPs Factor FIVE Gene genes encoding Genetic variant genetic variants genotypic haplotype analysis heterozygous higher risk homozygous human disease human diseases impair intron Intronic locus Lupus lupus erythematosus multiplex Pathogenesis populations Previous studies previous study probe Protein provide provided Regulation Significant SLE SNP SNPs subject suggested susceptibility systemic systemic lupus erythematosus tested variant variants
[DOI] 10.1371/journal.pgen.1002079 PMC 바로가기 [Article Type] Research Article

A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria

A −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article