Etiology and clinical characteristics of SARS-CoV-2 and other human coronaviruses among children in Zhejiang Province, China 2017–2019중국 저장성 어린이의 SARS-CoV-2 및 기타 인간 코로나바이러스의 병인 및 임상 특성 2017–2019Research Published on 2021-04-302022-09-10 Journal: Virology Journal [Category] MERS, SARS, 치료기술, [키워드] Acute respiratory infection acute respiratory symptom acute respiratory symptoms Analysis assays Chain Reaction children China circulating circulation Clinical characteristics clinical sample clinical samples common coronavirus country Epidemiology Gender genomes global public health HCoV HCoV-229E HCoV-HKU1 HCoV-NL63 HCoV-OC43 HCoVs HKU1 Hospitalized children human coronavirus human coronaviruses Infection information Lineage majority multiplex NL63 no significant differences Novel coronavirus novel coronaviruses OC43 occurred Occurrence Other respiratory viruses PCR analysis Phylogenic analysis polymerase chain polymerase chain reaction positive Region respiratory respiratory sample respiratory viruses Result reverse transcription reverse transcription-PCR RNA RT-PCR analysis Sample SARS-CoV-2 screened significant difference species specimen specimens study period submitted supplementary material Surveillance tested Zhejiang [DOI] 10.1186/s12985-021-01562-8 PMC 바로가기 [Article Type] Research
Mutational analysis and assessment of its impact on proteins of SARS-CoV-2 genomes from India인도 SARS-CoV-2 게놈의 단백질에 대한 돌연변이 분석 및 영향 평가Article Published on 2021-04-302022-09-11 Journal: Gene [Category] SARS, 변종, [키워드] affecting Amino acid amino acid sequence Analysis Asymptomatic Deceased detective faster female followed by Genome genomes geographical distribution highest in some incidence India male maximum Mutation nsp13 Nsp3 ORF3a pathophysiology Patient Protein PROVEAN Region S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence sequences SIFT the SARS-CoV-2 variant [DOI] 10.1016/j.gene.2021.145470 PMC 바로가기 [Article Type] Article
Global Discrepancies between Numbers of Available SARS-CoV-2 Genomes and Human Development Indexes at Country Scales국가 규모에서 사용 가능한 SARS-CoV-2 게놈 수와 인간 개발 지수 간의 글로벌 불일치Brief Report Published on 2021-04-282022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, [키워드] African analyzed Asia Asian capita China comparison Comparisons country country-scale development death deaths development discrepancy downloaded eight Europe European country File GDP Genome genome sequence genomes genomes sequenced GISAID database highlight Human Human Development Human Development Index Life expectancy Microsoft Excel Next-generation sequencing number Oceania Population size RANK ranking released SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences SARS-CoV-2 genomes scale Spread variant website world [DOI] 10.3390/v13050775 PMC 바로가기 [Article Type] Brief Report
Towards complete and error-free genome assemblies of all vertebrate speciesArticle Published on 2021-04-282022-10-04 Journal: Nature [Category] 유전자 메커니즘, [키워드] breakpoint canonical chromosome Complete complex develop disease duplications effort evaluate Evolutionary genetics GC-rich generate Genome genome assembly Genome assembly algorithms genomes Genomes Project Haplotype help include increases in independent International lineages molecular evolution protein-coding gene reference genome regions Regulatory repeated representing Research data sequence sequencing technology Vertebrate [DOI] 10.1038/s41586-021-03451-0 PMC 바로가기 [Article Type] Article
Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering장내 Bacteroidales의 이동형 VI 분비 시스템 유전자좌는 광범위한 생태계 내 이동, 다종 확산 및 지리적 클러스터링을 나타냅니다.Research Article Published on 2021-04-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition Analysis Bacterial Bacteroidale Bacteroidales benefit Clustering Community competitive advantage comprehensive analysis conjugation demonstrated dissemination distribution ecological Ecology element Evolution evolutionary dynamics exclusion expected fitness fixation Genes Genetic genetic architecture Genome genomes genomic globe Gut gut microbiota human population human populations identify Impact loci metagenomic metagenomic analyses microbial microbial ecosystem Microbiome Mobile multi neighboring cell neighboring cells observation phenotype Phenotypes Prevalence Recombination secretion species Spread strain Subtypes These data toxin toxins transfer transferred tRNA Type [DOI] 10.1371/journal.pgen.1009541 PMC 바로가기 [Article Type] Research Article
Intercellular viral spread and intracellular transposition of Drosophila gypsy초파리 집시의 세포간 바이러스 전파 및 세포내 전위Research Article Published on 2021-04-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence acquisition age aging ancestor animals arthropods assembly Author biological processe biological processes Cancer Cell chromosome chromosomes Combination develop disease Drosophila dysfunction element elements envelope gene Evidence exhibit exogenous retrovirus exogenous retroviruses expressed expression feature functional Genome genomes genomic germ line glial cell glial cells host genome implicated Implications incompatible increasingly infectious intercellular Like Long Long Terminal Repeat murine myriad neurodegeneration Neuron neurons occur organism plant plants Protein question raise related diseases Repeat replicate Replication retrotransposon retrotransposons retroviral retrovirus retroviruses similarity somatic cell somatic cells terminal the cell thought tissue transitioned Transmission Viral viral envelope protein viral spread Viral transmission viruses [DOI] 10.1371/journal.pgen.1009535 PMC 바로가기 [Article Type] Research Article
Genomic Analysis and Lineage Identification of SARS-CoV-2 Strains in Migrants Accessing Europe Through the Libyan Route리비아 경로를 통해 유럽에 접근하는 이민자의 SARS-CoV-2 균주의 게놈 분석 및 계통 식별Public Health Published on 2021-04-152022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 African asylum-seeker B.1 lineage conducted coronavirus Europe genetic variability Genetic variation genomes identification IMPROVE investigated knowledge Libya Lineage Local majority Mediterranean Sea migrant molecular molecular surveillance NGS Phylogenetic pilot study polymorphism positive Region representing rescued respiratory route SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 strains SARS-CoV-2 transmission sequence sequences Sequencing severe acute respiratory syndrome Coronavirus Sicily strain Surveillance sustained tested Transmission Transport Travel variants vessel Viral viral genome whole genome sequence [DOI] 10.3389/fpubh.2021.632645 PMC 바로가기 [Article Type] Public Health
GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid proteinGCG는 뉴클레오캡시드 단백질의 액상 응축을 방해하여 SARS-CoV-2 복제를 억제합니다.Article Published on 2021-04-092022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, 치료제, [키워드] Amino acid amino acid substitutions binding coding sequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disrupt disrupting exhibit gallate GCG Genome genome variant genomes GISAID GISAID database greater green tea identify IFN inhibit interfere knowledge leads nucleocapsid nucleocapsid protein polymorphism polyphenol Potential treatment predicted Protein Protein aggregation reveal RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication the SARS-CoV-2 Treatment Trigger triggers undergo Viral viral genome virion assembly viruses [DOI] 10.1038/s41467-021-22297-8 PMC 바로가기 [Article Type] Article
Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts감염된 숙주 내 및 전체에 걸친 SARS-CoV-2 돌연변이 축적의 시간적 역학Research Article Published on 2021-04-072022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] accumulate can not chance Cluster Cohort collected Community Consensus consensus sequence consensus sequences convergent evolution Coverage Critical defined determine Epidemic Epidemiology Evolution Frequency genetic diversity Genetic variant Genome sequencing genomes help high resolution hospitalized COVID-19 patient hospitalized COVID-19 patients Host identify identifying individual Infection investigated lineages low frequencies Metadata MONITOR Mutation Outbreaks Prevent Public health intervention Public health interventions reflect RNA SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 mutation SARS-CoV-2 transmission sequence sequenced Sequencing single medical center specimen Spread Strains symptom onset Temporal Transmission transmission of SARS-CoV-2 understanding unlikely utility variant variants Variation Viral Viral genome sequencing Viral load viral variant [DOI] 10.1371/journal.ppat.1009499 PMC 바로가기 [Article Type] Research Article
Effect of genome composition and codon bias on infectious bronchitis virus evolution and adaptation to target tissuesResearch Article Published on 2021-04-072022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] accessory protein accessory proteins acting Affect affecting appear bronchitis calculated Cell coding codon Codon Bias codon usage Codons Complete contribute CpG demonstrated downloaded Effect effective Evidence Evolution expressed gene expression level Factor Genome Genome composition genomes help Host IBV increase in Infectious Bronchitis Virus innate immune response investigated involved nucleotide Odds ratio phenotype polyprotein pp1a pp1ab Protein Proteins Regulation Result selective sequence significant difference strain structural protein supplementary material synonymous target tissue target tissues tissues virus without affecting [DOI] 10.1186/s12864-021-07559-5 PMC 바로가기 [Article Type] Research Article