healthy individual – Page 14 – Communicable Diseases Research

SARS-CoV-2-specific antibody rearrangements in prepandemic immune repertoires of risk cohorts and patients with COVID-19

코로나19 위험 집단과 환자의 전염병 전 면역 레퍼토리에서 SARS-CoV-2 특이 항체 재배열

Clinical Trial

Published on 2021-01-042022-09-12
Journal: The Journal of Clinical Investigation [Category] MERS, 임상, 진단,

Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19

COVID-19 환자를 위한 중요한 표지자로서의 기질 금속단백분해효소 3

Article

Published on 2021-01-012022-09-11
Journal: Journal of medical virology [Category] 바이오마커,

[키워드] analyzed biochemical center Chinese collected Concentration concentrations Control coronavirus disease Coronavirus disease 2019 Coronavirus pneumonia COVID-19 COVID-19 patient Cytokines detect detection healthy individual IL-1β IL-6 Inflammation Inpatients interleukin marker matrix matrix metalloproteinase Medicine metalloproteinase MMP3 MMP3 concentrations Non-COVID-19 normality Novel coronavirus patients with COVID-19 Pneumonia positive correlation prevention Prevention and control proinflammatory cytokines sera serum Serum level serum levels Severity of disease situation SPSS statistically significant Therapeutic approach therapeutic approaches two group two groups university Wilcoxon rank sum Wilcoxon rank sum test
[DOI] 10.1002/jmv.26235 PMC 바로가기 [Article Type] Article

A Rare Presentation of Cerebrovascular Accident in a COVID-19 Patient: A Case Report

Internal Medicine

Published on 2020-12-252022-10-31
Journal: Cureus [Category] COVID-19,

Cochrane corner: universal screening for SARS-CoV-2 infection

코크란 코너: SARS-CoV-2 감염에 대한 보편적인 스크리닝

Review

Published on 2020-12-162022-09-01
Journal: The Pan African Medical Journal [Category] MERS, SARS, 진단, 치료기술,

[키워드] Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition Asymptomatic baseline Care caused certainty of evidence Chain Reaction clinically Cochrane review Cohort cohort study conducted coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 COVID-19 infected individual COVID-19 infection COVID-19 infections COVID-19 symptoms Critically ill database detect disease Effect Effectiveness Eligible participants gold gold standard healthy individual highlight identify individual individuals infect infected cases infected individual infected individuals infected with SARS-CoV-2 Infection infectious Isolation Mild Mild disease MOST multiple organ failure non-specific Novel coronavirus participant polymerase chain reaction positive prevalence of COVID-19 proportion reported respiratory Result reverse transcriptase reverse transcriptase-polymerase chain reaction RT-PCR SARS-CoV-2 SARS-COV-2 infection screening strategy screening test screening test accuracy screening tests searched Septic shock Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spread Symptoms the disease transcriptase Travel Universal Universal screening Variability Variation
[DOI] 10.11604/pamj.supp.2020.37.1.26881 PMC 바로가기 [Article Type] Review

A blood transcriptome-based analysis of disease progression, immune regulation, and symptoms in coronavirus-infected patients

Article

Published on 2020-12-082022-10-04
Journal: Cell Death Discovery [Category] 바이오마커,

[키워드] adaptive Analysis Anti-viral applied approach available data B cell Blood cell types Comorbidity complex condition coronavirus COVID-19 patient cytokine Cytokines cytolytic diabetes disease Disease progression dysregulated Gene Expression Genes healthy individual healthy individuals help heterogeneity HLA-DQA1 HLA-F Hospitalization IFN-γ IL6 immune regulation Immune status Immunity immunology increases in Infection Innate immunity Lung disease management mimicking Molecular biology mononuclear cell Neutrophils observation outcome overlapping pandemic parameter Pathways Patient patients PBMC PBMCs Peripheral blood platform Pneumonia profile reduced response RNA SARS-CoV SARS-CoV-2 patient significantly stages subset Symptom Systems biology the disease Thromboembolism TNF
[DOI] 10.1038/s41420-020-00376-x PMC 바로가기 [Article Type] Article

Dose prediction for repurposing nitazoxanide in SARS‐CoV‐2 treatment or chemoprophylaxis

SARS-CoV-2 치료 또는 화학 예방에서 nitazoxanide 용도 변경을 위한 용량 예측

Original Article

Published on 2020-12-012022-08-31
Journal: British Journal of Clinical Pharmacology [Category] MERS, 신약개발, 진단, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus clinical trial clinical trials Concentration coronavirus COVID‐19 dose doses expected food global pandemic healthy individual healthy individuals Human in vitro activity lung maintain multiple dose nitazoxanide optimal dose pharmacokinetic pharmacokinetic data pharmacokinetics plasma predict predicted prevention strategies QID receiving regimen reported respiratory Result SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 seamless severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown TID tizoxanide Treatment Trial was used
[DOI] 10.1111/bcp.14619 PMC 바로가기 [Article Type] Original Article

Treatments in Covid-19 patients with pre-existing metabolic dysfunction-associated fatty liver disease: A potential threat for drug-induced liver injury?

Short communication

Published on 2020-12-012022-10-05
Journal: Biochimie [Category] 치료제,

[키워드] acute respiratory distress Antibiotics antiretroviral antiviral agent Bacterial contributed coronavirus disease COVID-19 COVID-19 patients cytochrome P450 Cytokine storm death disease drug Drug hepatotoxicity Drug-induced liver injury Enzymes Epidemic Factors Fatty liver fibrosis fungal healthy individual hepatotoxic higher risk Hospitalized Hypothesis induce insulin resistance lipid homeostasis liver main mechanism mechanism metabolic disease mitochondrial dysfunction multi-organ failure NASH non-infected obese COVID-19 patient obese COVID-19 patients obesity other disease oxidative stress participated Patient patients receive Remdesivir required risk severity steatohepatitis steatosis syndrome systemic inflammation treat
[DOI] 10.1016/j.biochi.2020.08.018 [Article Type] Short communication

Celebrex Adjuvant Therapy on Coronavirus Disease 2019: An Experimental Study

Pharmacology

Published on 2020-11-062022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] adjusted adjuvant age Analysis Atherosclerosis available data Cancer celebrex Clinical data Clinical outcome clinical study complications Concentration condition conducted control group coronavirus disease COVID-19 COVID-19 case COVID-19 group COVID-19 patient COX-2 CT scans death rate diabetes discharged dosage dose effective Endpoint enrolled evaluated experimental group healthy individual hospital indicate individuals lab morbidity and mortality mortality rate pandemic PGE PGE₂ positively correlated produced progression promote promoted prostaglandins reduce reduced Registered reported Seven severe COVID-19 severity significantly significantly higher Standard therapy suppress those with comorbidities Treatment Urine vital signs were measured
[DOI] 10.3389/fphar.2020.561674 PMC 바로가기 [Article Type] Pharmacology

Biomarkers of Hypercoagulability and Endothelial Cell Activation in Patients with Severe COVID-19 Admitted at the Intensive Care Unit. the Roadmap-COVID-19 Prospective Observational Study

Conference abstract

Published on 2020-11-042022-10-05
Journal: Blood [Category] 바이오마커,

[키워드] Activation acute respiratory distress acute respiratory syndrome Algorithm Antithrombotic AP-HP ARDS Biomarker Blood coagulation calculated cause cellular change characterized clinically clotting factor Cluster Coagulation cohort study complications consecutive patient Control control group controls coronavirus coronavirus disease COVID-19 D-dimer decrease disease download effect of treatment endothelial Endothelial cell Endothelial dysfunction enrolled evaluate evaluated excessive inflammation expressing fibrinogen FVIII healthy individual Heparanase Hospitalized hypercoagulability ICU ICU admission ICU patient IL-6 IL-6 level increase indicate indicated inflammatory reaction Inhaled inhibitor intensive care unit intrinsic life-threatening LMWH management mandatory Microparticle moderate modify molecular weight monomer MRI Multisystem organ failure outcome Paris pathway Patient patients patients hospitalized patients with COVID-19 peak platelet activation Pneumonia Prospective Prospective Study Protein protein S ranged Ratio Respiratory failure Result SARS-CoV-2 SARS-COV-2 infection severe COVID-19 shown significant decrease significantly STABLE syndrome table TFPI the mean the patient thrombin Thromboprophylaxis university von Willebrand factor were assessed with COVID-19
[DOI] 10.1182/blood-2020-140275 [Article Type] Conference abstract

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling

인터페론 신호 전달의 게놈 전체 단백질 정량적 형질 유전자좌 매핑에 의해 밝혀진 다발성 경화증 보호 HLA 클래스 I 대립 유전자의 기능

Research Article

Published on 2020-10-262022-09-06
Journal: PLoS Genetics [Category] Communicable Disease,

[키워드] addition Affect allele alleles Analysis Antigen presentation antigen-presenting function associations Autoimmune B and T cells B cell B cells CD27 Cell characterization contribute cytokine Cytokines demonstrated disease disease-associated Diseases Effect function functions genetic association Genetic association studies genetic associations genetic data Genetic polymorphism genetic polymorphisms genome-wide significant genotyped healthy individual healthy individuals HLA class I HLA class I alleles HLA locus HLA-A HLA-A*02 HLA-B HLA-J Host identify IFN IFNAR2 IFNs IGD Immune cell immune cells immune system immune-mediated disease immune-mediated diseases independent Infectious diseases Inflammatory interferon interferon receptor interferons interferons (IFNs interferons (IFNs) loci memory B cells microorganisms molecular mechanism molecular mechanisms mRNA expression multiple sclerosis neurologic nucleotide other disease other diseases Pathogenesis pathogenic patients performed protein level pseudogene receptor reduced regulated replicated response sclerosis Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs specific type T cell T cells These data to define transcriptional regulation Type I IFN type I interferon type II IFN virus viruses
[DOI] 10.1371/journal.pgen.1009199 PMC 바로가기 [Article Type] Research Article