SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β ProductionSARS-CoV-2 뉴클레오캡시드 단백질은 RIG-I와 상호작용하고 RIG 매개 IFN-β 생산을 억제합니다Article Published on 2020-12-302022-09-10 Journal: Viruses [Category] MERS, SARS, 치료법, [키워드] ATPase binding cellular clinical Clinical data Coronavirus disease 2019 COVID-19 demonstrated domain downstream highly pathogenic Human IFN IFN-β immunostimulatory Infection initial innate immune interferon interferon beta N protein nucleocapsid pathway Pattern recognition pattern recognition receptor poly(I:C poly(I:C) Production Protein PRR public health represse repressed responsible retinoic acid retinoic acid-inducible gene I RIG-I RNA viruses RNAs SARS-CoV-2 SARS-CoV-2 N protein Sendai virus SeV severe acute respiratory syndrome coronavirus 2 signaling molecule signaling molecules suggested suppresse suppressed the SARS-CoV-2 type I interferon virus infection [DOI] 10.3390/v13010047 PMC 바로가기 [Article Type] Article
Cardiovascular Comorbidities and Pharmacological Treatments of COVID-19 Patients Not Requiring HospitalizationObservational Study Published on 2020-12-252022-10-04 Journal: International Journal of Environmental Research an [Category] MERS, 임상, [키워드] 95% CI acute respiratory syndrome administration age anticoagulation Azithromycin cardiovascular cardiovascular comorbidity cardiovascular diseases Clinical characteristics clinical feature Combination Comorbidities Comorbidity coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient database described diabete distribution Drug administration earth evaluated Experimental drugs health emergency heparin highly pathogenic Hospitalization hypertension infected patient inhibitors Italy laboratory-confirmed low molecular weight heparin majority males management material Naples outbreak outpatient’s setting Patient performed pharmacological physician Prevalence prevalent primary care Regression model responsible Retrospective analysis risk Risk factors SARS-CoV-2 significantly study population therapy treated Venous Thromboembolism weight [DOI] 10.3390/ijerph18010102 PMC 바로가기 [Article Type] Observational Study
Prognostic Value of Fibrinogen among COVID-19 Patients Admitted to an Emergency Department: An Italian Cohort StudyArticle Published on 2020-12-212022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] activated acute illness acute respiratory distress acute respiratory syndrome Admission ARDS baseline level characterized control group control groups coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients cut-off value D-dimer diagnosis of COVID-19 Disseminated intravascular coagulation Dyspnea Emergency evaluated Fever fibrinogen help Hemostasis highly pathogenic Hospital admission hospitals identify increase in induce Italian Laboratory large cohort material pandemic parameter Patient performed Physical examination Prognostic marker Prognostic value prothrombin SARS-CoV-2 sensitivity Serum level specificity statistically significant syndrome the disease value [DOI] 10.3390/jcm9124134 PMC 바로가기 [Article Type] Article
Human coronavirus dependency on host heat shock protein 90 reveals an antiviral targetResearch Article Published on 2020-12-172022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] 17-AAG Antiviral antiviral target approved cell line cellular chaperone co-immunoprecipitation coronavirus Coronaviruses dependent on Heat shock highly pathogenic Host host cell Hsp90β Human human coronaviruses inhibited inhibitor Interaction Intestinal Organoids maintain MERS-CoV nucleoprotein Protein Rapid Replication required reveal SARS-CoV SARS-CoV-2 second significantly siRNA stability suppressed Viral protein viral replication virus virus spread [DOI] 10.1080/22221751.2020.1850183 PMC 바로가기 [Article Type] Research Article
The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1SARS, MERS, EBOV 및 H1N1과 비교한 SARS-CoV-2의 전사체 프로파일링Comparative Study Published on 2020-12-102022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 신종인플루엔자, 유전자 메커니즘, [키워드] Analysis anti-SARS-CoV-2 Arthritis association cellular claimed Comparative analysis COVID-19 Cytokines demonstrated determine FGF1 FIVE FOXO1 gene signature Genes Genetic global mortality GO term GO terms H1N1 heparin hepatitis B highly pathogenic host antiviral responses IL-6 IL-8 immune regulation Infection Inflammatory responses Influenza influenza A inhibitor Interaction involved life malaria MERS MERS-CoV miRNA modulation molecular NRCAM other respiratory virus Other respiratory viruses pandemic pathway potential therapy PPI protein-protein interaction provide RAGE respiratory respiratory viruses rheumatoid arthritis SAA2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SERPINB1 Signaling significantly target the SARS-CoV-2 therapeutic Transcriptome transcriptomic understanding unique Viral viral infection viral infections virus viruses [DOI] 10.1371/journal.pone.0243270 PMC 바로가기 [Article Type] Comparative Study
COVID-19 and Palliative Care Services: Comparative Patterns of Inpatient, Outpatient, and Consultation Services in a Tertiary Care Center in RiyadhPain Management Published on 2020-12-092022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome affecting applied Care caused center city Comparative conducted consultation coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) country COVID-19 COVID-19 outbreak COVID-19 pandemic death discharged home Epidemic examined family healthcare worker highly pathogenic hospital hospitals impact on service initial Inpatient King outbreak Outpatient palliative palliative and supportive care Palliative care pandemic Patient pattern positive COVID-19 PPS Practice patterns Precaution protocols provided Result Retrospective study SARS-CoV-2 sars-cov-2 (severe acute respiratory syndrome coronavirus -2) Saudi Arabia service Tertiary World Health Organization [DOI] 10.7759/cureus.11996 PMC 바로가기 [Article Type] Pain Management
Biologically active compounds from marine organisms in the strategies for combating coronavirusesReview Published on 2020-12-072022-10-27 Journal: AIMS Microbiology [Category] COVID-19, [키워드] Affect analysed Antiviral antiviral activity antiviral agent antiviral drugs biologically active substances caused Cell cellular cellular pathway clinical trials combating Compound coronavirus Coronaviruses database effective therapy Elsevier experiment Google Scholar Health highly pathogenic Host immunization Infection Lipid marine organisms MERS-CoV Middle East organism penetration peptides polysaccharides Prophylactic Replication researcher resource respiratory syndrome coronavirus SARS-CoV SARS-CoV-2 Stage targets Topic Vaccine viral infections viral nucleic acid viral particle virion viruses Web of Science [DOI] 10.3934/microbiol.2020028 PMC 바로가기 [Article Type] Review
Multiple SARS-CoV-2 Introductions Shaped the Early Outbreak in Central Eastern Europe: Comparing Hungarian Data to a Worldwide Sequence Data-Matrix여러 SARS-CoV-2 도입으로 중부 동유럽 초기 발병 형성: 헝가리 데이터를 전세계 시퀀스 데이터 매트릭스와 비교Comparative Study Published on 2020-12-062022-09-10 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Analysis applied China clinical sample clinical samples collected Complete confirmed COVID-19 patients coronavirus coronavirus 2 COVID-19 patient disease Europe event Evolution full-length SARS-CoV-2 genome genomic sequence GISAID database Haplotype highly pathogenic human coronavirus Hungary Laboratory mechanism Multiple network analysis outbreak pandemic performed phylodynamics Phylogenetic Recognition respiratory SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 sequence SARS-CoV-2 sequences Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 situation the epidemic [DOI] 10.3390/v12121401 PMC 바로가기 [Article Type] Comparative Study
Genomic and evolutionary comparison between SARS-CoV-2 and other human coronavirusesArticle Published on 2020-12-052022-11-01 Journal: Journal of virological methods [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome approach characterization clade Clustering codon codon usage complementary coronavirus COVID-19 CpG Dinucleotide suppression ecological niche Evolution genomic heterogeneity highly pathogenic Host human coronavirus human pathogen humans indicated infect Interaction MERS-CoV number pandemic pathogenicity Phylogenetic Phylogenetic analysis phylogenetics Phylogeny SARS-CoV SARS-CoV-2 SARS-CoV-2 genome trimer [DOI] 10.1016/j.jviromet.2020.114032 PMC 바로가기 [Article Type] Article
Molecular targets for COVID-19 drug development: Enlightening Nigerians about the pandemic and future treatmentReview article Published on 2020-12-012022-10-05 Journal: Biosafety and Health [Category] 치료제, [키워드] 3CLpro ACE2 receptor acute respiratory disease acute respiratory syndrome assigned binding caused chloroquine/hydroxychloroquine Combination coronavirus Coronavirus disease 2019 COVID-19 develop disease Drug development targets dry cough Fever Helicase highly pathogenic host infection identify imperative Infection initiated loss of taste management membrane Molecular pathogenesis mRNA-1273 nasal congestion nucleocapsid pandemic Pathogenesis Patient positive Protein RdRP Replication reported Research RNA SARS-CoV-2 SARS-COV-2 infection sore throat Spike protein structural protein Symptom target tiredness Treatment Vaccine Vaccine development viral infection viral RNA synthesis virus Wuhan, China [DOI] 10.1016/j.bsheal.2020.07.002 [Article Type] Review article