Detection and Neutralization of SARS-CoV-2 Using Non-conventional Variable Lymphocyte Receptor Antibodies of the Evolutionarily Distant Sea Lamprey진화적으로 먼 바다 칠면조의 비전통적인 가변 림프구 수용체 항체를 사용한 SARS-CoV-2의 검출 및 중화Immunology Published on 2021-06-212022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] antibody Betacoronavirus Biomedical research causative agent COVID-19 pandemic detection diagnostic diagnostic reagent Distant Epitopes Evidence immune responses immunized immunoglobulins Isolation lamprey lymphocyte monoclonal monoclonal antibody neutralization neutralize other coronaviruses pathogen provide receptor recognize recognizing SARS-CoV-2 SARS-CoV-2 detection sea lamprey (Petromyzon marinus) Spike protein spike protein of SARS-CoV-2 the spike protein therapeutic unique vaccine-induced immune response variable variable lymphocyte receptor Vertebrate Viral viral spike protein virus [DOI] 10.3389/fimmu.2021.659071 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2-Induced Multisystem Inflammatory Syndrome in a Young Adult: Case ReportCovid-19 Published on 2021-06-202022-10-29 Journal: Sn Comprehensive Clinical Medicine [Category] COVID-19, [키워드] Atypical clinical feature COVID-19 criteria Cytokine storm Glucocorticoids healthy heart failure high mortality HLH Hyperinflammatory immunoglobulins Inflammatory macrophage activation syndrome male MIS Multiorgan Multisystem inflammatory syndrome overlapping potentially life-threatening report SARS-CoV-2 SARS-COV-2 infection Shock syndrome therapy treated Volume [DOI] 10.1007/s42399-021-00998-x PMC 바로가기 [Article Type] Covid-19
First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in subjects who have recovered from COVID-19첫 번째 접종 mRNA 백신 접종은 COVID-19에서 회복된 피험자에서 SARS-CoV-2에 대한 면역학적 기억을 재활성화하기에 충분합니다.Article Published on 2021-06-152022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 진단, [키워드] Adaptive immune response Adaptive immunity B cell responses BNT162b2 mRNA cellular Clinical practice Cohort contrary COVID-19 COVID-19 vaccination COVID-19 vaccine determine ENhance evaluated humoral immune response IgA IgG IgM immune response Immunity immunoglobulins Immunological memory immunology individual individuals injection mandatory mRNA vaccination neutralizing antibodies titer performed question required SARS-CoV-2 SARS-COV-2 infection second dose serological subject subjects T cells tested vaccination vaccine dose vaccine injection [DOI] 10.1172/JCI149150 PMC 바로가기 [Article Type] Article
Association of Guillain-Barre syndrome with COVID-19 infection: An updated systematic reviewCOVID-19 감염과 길랑-바레 증후군의 연관성: 업데이트된 체계적인 검토Article Published on 2021-06-152022-09-11 Journal: Journal of neuroimmunology [Category] SARS, 변종, [키워드] Acute inflammatory demyelinating polyneuropathy age Analysis analyzed article articles business cerebrospinal fluid Chain Reaction Clinical characteristics Clinical features Complication complications COVID-19 COVID-19 infection CSF database demographic and clinical characteristics demographic characteristics determine develop diagnosed diagnostic workup facial facial diplegia Fisher syndrome Follow-up function functions Glucose Guillain-barrè syndrome IBM Immunoglobulin immunoglobulins index Infection Inflammatory IVIG lab literature lower extremity machine majority male management Mann-Whitney U test Miller-Fisher syndrome. MOST Most patients neurological Novel coronavirus Nursing other variant other variants paresis paresthesia Patient patients Polyneuropathy protocol receive respiratory insufficiency reverse transcriptase reverse transcriptase-polymerase chain reaction RT-PCR searched SPSS Statistical tests Statistics Symptom syndrome systematic review t-test the patient Web of Science were used with COVID-19 [DOI] 10.1016/j.jneuroim.2021.577577 PMC 바로가기 [Article Type] Article
One dose of SARS-CoV-2 vaccine exponentially increases antibodies in individuals who have recovered from symptomatic COVID-19SARS-CoV-2 백신 1회 투여량은 증상이 있는 COVID-19에서 회복된 개인의 항체를 기하급수적으로 증가시킵니다.Clinical Trial Published on 2021-06-152022-09-12 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, 진단, [키워드] Adaptive immunity administration antibodies antibody Antibody Response Care COVID-19 COVID-19 vaccine dose Fever first dose Gastrointestinal Health IgG IgG responses immunoglobulins immunology increase individual individuals Italian Linear regression Ministry of Health Pain Pfizer/BioNTech positively correlated professionals reached receive receiving retained SARS-CoV-2 SARS-CoV-2 vaccine second dose subject symptomatic Symptoms tested the antibody response Vaccine vaccine dose Vaccines [DOI] 10.1172/JCI149154 PMC 바로가기 [Article Type] Clinical Trial
Immunomodulation: Immunoglobulin Preparations Suppress Hyperinflammation in a COVID-19 Model via FcγRIIA and FcαRI면역 조절 : 면역 글로불린 제제는 FcγRIIA 및 FCαRI를 통해 COVID-19 모델에서 과인 염증을 억제합니다.Immunology Published on 2021-06-102022-08-31 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단, [키워드] “cytokine storm” Activation addition Anti-inflammatory antibody cells characterized Clinical outcome coated with convalescent plasma COVID-19 COVID-19 disease COVID-19 pathology cytokine cytokine release Cytokine storm dissect drug dysregulated immune response elicit Fc-receptors FcγR followed by form functional global pandemic highlighting HL60 human immunoglobulin IgA IgG IgG and IgM IgM antibodies immune complex immune modulation immune modulatory drug immune modulatory drugs immune response Immunoglobulin immunoglobulins IMPROVE in vitro model include Inflammation Inflammatory Intravenous immunoglobulin ITAMi IVIG Model neutrophil Neutrophils pathology patients phagocytosis preparation reduced SARS-CoV-2 severe COVID-19 patients severe forms of COVID-19 Signaling Spike protein Spread tested therapeutic trimodulin [DOI] 10.3389/fimmu.2021.700429 PMC 바로가기 [Article Type] Immunology
Available COVID-19 serial seroconversion panel for validation of SARS-CoV-2 antibody assaysArticle Published on 2021-06-012023-06-19 Journal: Diagnostic microbiology and infectious disease [Category] MERS, SARS, [키워드] COVID-19 immunoglobulins SARS-CoV-2 Seroconversion panel. [DOI] 10.1016/j.diagmicrobio.2021.115340 PMC 바로가기
Clinical Management of COVID-19: A Review of Pharmacological Treatment OptionsReview Published on 2021-05-282022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] administration of corticosteroid antivirals applied approval approved casirivimab/imdevimab Chloroquine clinical clinical experience Clinical management clinical study conducted convalescent plasma COVID-19 COVID-19 pandemic COVID-19 therapeutics curtail disease drug drugs Effect Efficacy Efficacy and safety effort Emergency evaluated Evidence Favipiravir FDA global pandemic global scientific community Google Scholar Hydroxychloroquine immunoglobulins interferons intravenous lack management Molecular biology off-label option outbreak pathophysiology pharmacological agent public health reduce REGN-CoV2 Remdesivir Repurposed drug review risk SARS-CoV-2 Scientific community shown Spread standard treatment subsequent the disease therapeutic therapy tissue plasminogen activator Tocilizumab Treatment umifenovir Vaccine Volume while [DOI] 10.3390/ph14060520 PMC 바로가기 [Article Type] Review
SARS-CoV-2 evolution in an immunocompromised host reveals shared neutralization escape mechanisms면역 저하된 숙주에서 SARS-CoV-2 진화는 공유된 중화 탈출 메커니즘을 보여줍니다Article Published on 2021-05-132022-09-11 Journal: Cell [Category] Fulltext, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Affinity maturation antibody Antibody neutralization Antibody Response circulating Clinical use convalescent COVID-19 Critical domain Donor Efficacy Evolution globe healthy Host Immunocompromised Immunocompromised host immunoglobulins implication individual mechanism monoclonal antibodies monoclonal antibody Mutation neutralization neutralization breadth neutralization escape Neutralizing antibodies polyclonal predict Protein pseudotype RBD resistance responses reveal S variant SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody serum immunoglobulin Structure tested variant variants variants of concern Viral viral spike virus Virus evolution wild-type virus [DOI] 10.1016/j.cell.2021.03.027 PMC 바로가기 [Article Type] Article
Human Milk from Previously COVID-19-Infected Mothers: The Effect of Pasteurization on Specific Antibodies and Neutralization Capacity이전에 COVID-19에 감염된 산모의 모유: 저온 살균이 특정 항체 및 중화 능력에 미치는 영향Clinical Trial Published on 2021-05-132022-08-13 Journal: Nutrients [Category] SARS, 임상, 진단, 치료법, [키워드] affected antibodies antibody approach assays Breastfeeding Capacity case control study collected complementary coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 determine Effect effective ELISA healthy controls Holder Human human milk IgA IgG IgM immunization immunoglobulins lactating milk mother N protein neutralization capacity Neutralizing neutralizing capacity no correlation nucleocapsid outbreak passive immunization pasteurization pressure Protein pseudovirus RBD Receptor binding domain retained Safe SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 RBD SARS-CoV-2 specific antibodies SARS-CoV-2 specific antibody SARS-CoV-2 spike protein serum serum sample serum samples Specific specific antibodies Spike protein syndrome the SARS-CoV-2 [DOI] 10.3390/nu13051645 PMC 바로가기 [Article Type] Clinical Trial