Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and VancomycinFull Paper Published on 2020-07-302022-10-31 Journal: ChemMedChem [Category] Coronavirus, [키워드] active against analogue Antibiotics Antiviral antiviral activity antiviral agent antiviral drug Bacteria block concentrations coronavirus cytotoxicity derivative evaluated glycopeptide antibiotic Health herpes simplex hydrophobic inactive Influenza virus influenza viruses inhibitor linker nontoxic perfluoroalkyl plan selective synthesis Teicoplanin vancomycin virus viruses [DOI] 10.1002/cmdc.202000260 PMC 바로가기 [Article Type] Full Paper
Changes of Physical Activity and Ultra-Processed Food Consumption in Adolescents from Different Countries during Covid-19 Pandemic: An Observational StudyArticle Published on 2020-07-302022-10-30 Journal: Nutrients [Category] Coronavirus, SARS, [키워드] activity Adolescent Brazil change Consumption country COVID-19 pandemic cross-sectional study e-survey Europe female Final food Frequency Google Forms healthy inactive Italy Latin America less lockdown Logistic regression mother multinomial logistic Odds ratio pandemic physical activity predictor Prevalence prevalent reduction Sample social isolation Sociodemographic Spain variables was performed were used [DOI] 10.3390/nu12082289 PMC 바로가기 [Article Type] Article
The Impact of COVID-19 on Physical Activity Behavior and Well-Being of CanadiansArticle Published on 2020-05-312022-10-30 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] 2019 novel coronavirus diseases (COVID-19) activity affected Anxiety Behavior Canadian Canadians caused COVID-19 daily living global pandemic Health Impact impacted inactive individual individuals less Lifestyle restrictions measure National Novel coronavirus outcome participant physical activity Public Result significant difference social distancing Well-being [DOI] 10.3390/ijerph17113899 PMC 바로가기 [Article Type] Article
Comparative Antiviral Activity of Remdesivir and Anti-HIV Nucleoside Analogs against Human Coronavirus 229E (HCoV-229E)Brief Report Published on 2020-05-172022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] 229E activity Antiviral antiviral activity can be used cells clinical trial Comparative Compound compounds concentrations conjugate Conjugates COVID-19 cytotoxicity determine DNA polymerase EFdA exhibited fibroblast HCoV-229E human coronavirus human coronavirus 229E inactive inhibitor interfere lung cell normal NRTIs nucleoside nucleotide prodrug other coronaviruses parent Remdesivir RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 tested Treatment were used with HIV [DOI] 10.3390/molecules25102343 PMC 바로가기 [Article Type] Brief Report
Effectiveness of HIIT compared to moderate continuous training in improving vascular parameters in inactive adults비활동 성인의 혈관 매개변수 개선에 있어 중간 정도의 지속적인 훈련과 비교한 HIIT의 효과Research Published on 2019-02-042022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] 95% CI Adults Aerobic exercise Analysis Arterial stiffness baseline both group both groups brachial brachial artery calculated cancers cardiovascular disease Cardiovascular disease prevention changed Colon condition conditions CVD determine Effect Endothelial dysfunction Evidence greater group Health heart rate IMPROVE improvement Improvements inactive increase individuals interval training Life expectancy metabolic syndrome moderate no significant difference non-communicable diseases normalized parameter parameters participant Physical inactivity physically Prevalence proportion pulse Pulse wave pulse wave velocity Randomly receive Registered Result risk Sedentarism significant difference Strong supplementary material syndrome Trial registration Vascular Vascular function were measured [DOI] 10.1186/s12944-019-0981-z PMC 바로가기 [Article Type] Research
Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis막내 단백질 분해의 조절이 Bacillus subtilis에서 포자 형성 동안 기질 게이팅에 의해 매개된다는 증거Research Article Published on 2018-11-072022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activate Activation active form association Bacillus subtilis catalytic center catalyzed CBS Cell cells cleavage cleave cleaving co-immunoprecipitation conformation conformational change conserved Critical cystathionine cytoplasmic daughter cells domain enzyme Evidence Extracellular family member fluorescence microscopy forespore Gene Expression homolog immunoprecipitation in vivo inactive information Interaction interaction site interior late stage mechanism membrane membrane protein Methanocaldococcus Morphological mother mother cell open pathway Pathways protease proteolysis proteolytic activation Regulation remained secreted Signal transduction Signaling signaling pathway Space sporulation Support transcription factor transducing Trigger triggers [DOI] 10.1371/journal.pgen.1007753 PMC 바로가기 [Article Type] Research Article
Bacterial sensing: A putative amphipathic helix in RsiV is the switch for activating σ V in response to lysozyme박테리아 감지: RsiV의 추정되는 양친매성 나선은 리소자임에 대한 반응으로 σ V를 활성화하는 스위치입니다.Research Article Published on 2018-07-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence activating Activation addition Bacillus Bacillus subtilis Bacteria binding changes in charged residue cleavage cleavage site cleave cleaved Degradation Disruption domain Evidence Factor Firmicute firmicutes function Gene Expression hydrophobic inactive indicated inhibitor lysozyme membrane molecular peptidase PROTECT regulated required resistance genes respond responsible signal substrate substrates translocated Trigger triggering triggers unique [DOI] 10.1371/journal.pgen.1007527 PMC 바로가기 [Article Type] Research Article
A novel mechanism of RNase L inhibition: Theiler’s virus L* protein prevents 2-5A from binding to RNase LResearch Article Published on 2018-04-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, [키워드] accumulate activate activating Activation Antiviral antiviral response Apoptosis ATP bind binding Cell cellular Central nervous system chimeric contributing to Coronaviruses degrade double-stranded RNA effective enzyme expressing flu IFN in vivo inactive infected cell infected cells Infection inhibit interferon killing mechanism MHV mouse hepatitis virus murine OAS oligomerization pathway Pathways Prevent produced promote Protein Replication RNase these cell triggering upstream Viral protein Viral RNA virus virus replication virus spread [DOI] 10.1371/journal.ppat.1006989 PMC 바로가기 [Article Type] Research Article
Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cellsB 세포 발달 동안 비활성 X에서 Xist RNA의 손실은 활성화된 B 세포에서 동적 YY1 종속 2단계 과정으로 복원됩니다.Research Article Published on 2017-10-092022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation adulthood Autoimmune disorders Autoimmunity B cell B cells Cell change chromatin chromosome compensated Critical develop DNA DNA binding domain dosage ectopic expression embryogenesis Epigenetic Ex vivo expression female Genes Genetic heterochromatin Immunity impair inactivation inactive indicate lack Lineage Loss lymphocyte Lymphocytes mechanism Modification modifications pathogenic pattern Recombination regulate regulated restored reveal RNA Stimulation susceptibility transcription factor up-regulation X-linked X-linked gene YY1 Zinc [DOI] 10.1371/journal.pgen.1007050 PMC 바로가기 [Article Type] Research Article
Signaling through Lrg1, Rho1 and Pkc1 Governs Candida albicans Morphogenesis in Response to Diverse CuesLrg1, Rho1 및 Pkc1을 통한 신호는 다양한 신호에 대한 응답으로 Candida albicans 형태 형성을 제어합니다Research Article Published on 2016-10-272022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Activation adenylyl cyclase allele Analysis blocked CAMP Candida Candida albican Candida albicans canonical cascade Cell cell growth concert Critical defined Deletion developmental disease downstream example form function functional fungal fungal pathogens Genetic growth GTPase healthy homozygous hosts Human humans hyphal identify Immunocompromised implicated inactive independent independent of Infection insertion invasive leads Lrg1 morphogenesis Morphological morphology mutant Mutation not impaired pathogen Pathogenesis Pathogens pathway positive promoted reduced regulate represse repression required response screened serum signaling pathway skin infections strain Strains transition transposon virulence yeast [DOI] 10.1371/journal.pgen.1006405 PMC 바로가기 [Article Type] Research Article