Elevated Exhaustion Levels of NK and CD8 + T Cells as Indicators for Progression and Prognosis of COVID-19 Disease
COVID-19 질병의 진행 및 예후 지표로서의 NK 및 CD8 + T 세포의 고갈 수준 증가
Immunology
[키워드] (PD-1)
acute respiratory syndrome coronavirus
analyzed
association
Blood
CD16
CD244
CD3
CD4
CD56
CD8
Cell
cell population
Characteristics
circulating
Clinical data
collected
contribute
coronavirus
coronavirus 2
coronavirus disease
Coronavirus disease 2019
Coronavirus disease 2019 (COVID-19)
COVID-19
COVID-19 patient
Critical
Critical illness
cytokine
Cytokines
demographic
disease
disease severity
dysregulation
effector molecule
elevated
eliminating
enrolled
evaluated
Exhaustion
expression
flow cytometry
functional
IL-10
IL-6
immune dysregulation
immune system
IMPROVE
Indicator
infected cells
Level
Logistic regression
logistic regression model
lymphocyte
Lymphocyte subset
Lymphocyte subsets
natural killer
natural killer (NK) cells
NK cell
NK cells
NKT cell
NKT cells
Pathogenesis
Patient
patients with COVID-19
PD-1
percentage
percentages
perforin
phenotypic
predict
Prognosis
progression
public health
reduced
Regulatory
respiratory
Result
risk factor
Risk factors
SARS-CoV-2
screened
serum
Serum IL-6
Serum level
serum levels
severe acute respiratory syndrome coronavirus 2
Severe case
severe cases
severe COVID-19 patients
severe patients
severe symptoms
severity of COVID-19
significantly
significantly increased
subset
T cell
T cells
TNF-α
Union Hospital
virus
Wuhan
[DOI] 10.3389/fimmu.2020.580237 PMC 바로가기 [Article Type] Immunology
[DOI] 10.3389/fimmu.2020.580237 PMC 바로가기 [Article Type] Immunology